NeuroImmunology
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Scooped by Gilbert C FAURE
October 22, 2014 2:44 PM
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TRIL is involved in cytokine production in the bra... [J Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 21, 2014 11:00 AM
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Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma, Expert Opinion on Biological Therapy, Informa Healthcare

Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma, Expert Opinion on Biological Therapy, Informa Healthcare | NeuroImmunology | Scoop.it
Abstract- Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma... http://t.co/rKjrx4XwY3 http://t.co/DyZHMmNTiN
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Scooped by Gilbert C FAURE
October 20, 2014 1:11 PM
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Effect of repeated alcohol exposure during the third trimester-equivalent on messenger RNA levels for interleukin-1β, chemokine (C-C motif) ligand 2, and interleukin 10 in the developing rat brain ...

Effect of repeated alcohol exposure during the third trimester-equivalent on messenger RNA levels for interleukin-1β, chemokine (C-C motif) ligand 2, and interleukin 10 in the developing rat brain ... | NeuroImmunology | Scoop.it
Microglia undergo maturation during the third trimester of human development (equivalent to the first 1–2 weeks of postnatal life in rodents), during which these cells may be particularly sensitive to insult.
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Scooped by Gilbert C FAURE
October 20, 2014 1:11 PM
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CXCR4 chemokine receptor signaling mediates pain in... [Mol Pain. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 17, 2014 2:47 PM
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BMC Neurology | Abstract | Changes in lymphocyte subsets in patients with Guillain-Barré syndrome treated with immunoglobulin

Guillain-Barré syndrome (GBS) is an autoimmune condition characterized by peripheral neuropathy. The pathogenesis of GBS is not fully understood, and the mechanism of how intravenous immunoglobulin (IVIG) cures GBS is ambiguous.
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Scooped by Gilbert C FAURE
October 17, 2014 1:55 PM
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A Role for Neuropilins in the Interaction between Schwann Cells and Meningeal Cells

A Role for Neuropilins in the Interaction between Schwann Cells and Meningeal Cells | NeuroImmunology | Scoop.it
by Kasper C. D. Roet, Kerstin T. S. Wirz, Elske H. P.
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Scooped by Gilbert C FAURE
October 17, 2014 10:54 AM
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Elevated levels of cerebrospinal fluid ... [Front Aging Neurosci. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:

Mutations in the leucine-rich repeat kinase 2 gene are the most common cause of autosomal dominant Parkinson's disease (PD). To assess the cerebrospinal fluid (CSF) levels of α-synuclein oligomers in symptomatic and asymptomatic leucine-rich repeat kinase 2 mutation carriers, we used enzyme-linked immunosorbent assays (ELISA) to investigate total and oligomeric forms of α-synuclein in CSF samples

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Scooped by Gilbert C FAURE from Genetic Engineering Publications - GEG Tech top picks
October 17, 2014 10:53 AM
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A three-dimensional human neural cell culture model of Alzheimer/'s disease - Nature




Via BigField GEG Tech
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the original paper

BigField GEG Tech's curator insight, October 13, 2014 9:47 AM

The authors designed a unique strategy for recapitulating Alzheimer’s disease pathology in a 3D neural cell culture model which should also serve to facilitate the development of more precise human neural cell models of other neurodegenerative disorders.


http://geg-tech.com/

Scooped by Gilbert C FAURE
October 16, 2014 3:03 PM
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Frontiers | DQB1*06:02-Associated Pathogenic Anti-Myelin Autoimmunity in Multiple Sclerosis-Like Disease: Potential Function of DQB1*06:02 as a Disease-Predisposing Allele | Tumor Immunity

Susceptibility to Multiple Sclerosis (MS) has been linked mainly to the HLA-DRB1 locus, with the HLA-DR15 haplotype (DRB1*1501-DQA1*0102-DQB1*0602- DRB5*0101) dominating MS-risk in Caucasians. Alth...
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Scooped by Gilbert C FAURE
October 13, 2014 2:45 PM
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Multiple sclerosis: summary of NICE guidance

#Multiple #sclerosis: summary of #NICE guidance http://t.co/FNtt3fJxL4 #MS
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Scooped by Gilbert C FAURE
October 12, 2014 3:11 PM
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Gut microbiome and the risk factors in central ner... [FEBS Lett. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 10, 2014 10:50 AM
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Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody, Expert Opinion on Drug Delivery, Informa Healthcare

Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody, Expert Opinion on Drug Delivery, Informa Healthcare | NeuroImmunology | Scoop.it
Blood–brain barrier DD of IgG fusion proteins with a Tf receptor monoclonal antibody by Bill Pardridge, ArmaGen Techn http://t.co/mFTVUEFkOm
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Scooped by Gilbert C FAURE
October 10, 2014 5:52 AM
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Gene expression analysis of histamine recepto... [J Neuroimmunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:
in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different stages of multiple sclerosis.
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Scooped by Gilbert C FAURE
October 21, 2014 11:02 AM
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Science | From AAAS

Aging-induced type I interferon response at the choroid plexus negatively affects #brain function http://t.co/me4rw7Y9wF #neuroscience
Gilbert C FAURE's insight:

Aging-associated cognitive decline is affected by factors produced inside and outside the brain. By using multiorgan genome-wide analysis of aged mice, we found that the choroid plexus, an interface between the brain and the circulation, shows a type I interferon (IFN-I)–dependent gene expression profile that was also found in aged human brains. In aged mice, this response was induced by brain-derived signals, present in the cerebrospinal fluid. Blocking IFN-I signaling within the aged brain partially restored cognitive function and hippocampal neurogenesis and reestablished IFN-II–dependent choroid plexus activity, which is lost in aging. Our data identify a chronic aging-induced IFN-I signature, often associated with antiviral response, at the brain’s choroid plexus and demonstrate its negative influence on brain function, thereby suggesting a target for ameliorating cognitive decline in aging.

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Scooped by Gilbert C FAURE from Alzheimer's Disease R&D Review
October 21, 2014 10:58 AM
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Alzheimer's disease: Making Aβ better - Nature.com

Alzheimer's disease: Making Aβ better Nature.com Microglia express a number of genes that have been implicated in the pathology of Alzheimer's disease (AD), which is characterized by extracellular accumulation of amyloid-β peptide (Aβ) peptides and...

Via Krishan Maggon
Krishan Maggon 's curator insight, October 20, 2014 12:43 PM
A small molecule binding HMGB1 and HMGB2inhibits microglia-mediated neuroinflammationSanghee Lee,Youngpyo Nam,Ja Young Koo,Donghyun Lim,Jongmin Park,Jiyeon Ock,Jaehong Kim,Kyoungho Suk& Seung Bum ParkAffiliationsContributionsCorresponding authorsNature Chemical Biology (2014) doi:10.1038/nchembio.1669Received 19 March 2014 Accepted 18 September 2014 Published online 12 October 2014
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October 20, 2014 1:11 PM
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A Multiple Sclerosis-Associated Variant of CBLB Links Genetic Risk with Type I IFN Function [AUTOIMMUNITY]

Multiple sclerosis (MS) is an autoimmune disease of the CNS, and autoreactive CD4+ T cells are considered important for its pathogenesis.
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Scooped by Gilbert C FAURE
October 18, 2014 10:15 AM
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Therapeutic uses of anti-α4-integrin (anti-VLA-4) antibodies in multiple sclerosis

Therapeutic uses of anti-α4-integrin (anti-VLA-4) antibodies in multiple sclerosis | NeuroImmunology | Scoop.it
Therapeutic uses of anti-{alpha}4-integrin (anti-VLA-4) antibodies in multiple sclerosis http://t.co/gO0pYsupA8
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Scooped by Gilbert C FAURE
October 17, 2014 2:45 PM
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A clinical and neurobiological case of IgM NM... [Psychiatry Res. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 17, 2014 10:55 AM
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Frontiers | Cilia in the choroid plexus and their link to brain disorders | Frontiers in Cellular Neuroscience

Cilia are whip-like projections that are widely conserved in eukaryotes and function as a motile propeller and/or sensory platform to detect various extracellular stimuli. In vertebrates, cilia are...
Gilbert C FAURE's insight:

epithelial cells are indeed ciliated

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Scooped by Gilbert C FAURE
October 17, 2014 10:54 AM
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A rapid method for preparation of the cerebrospinal fluid proteome - Larssen - PROTEOMICS - Wiley Online Library

A rapid method for preparation of the cerebrospinal fluid proteome - Larssen - PROTEOMICS - Wiley Online Library | NeuroImmunology | Scoop.it
"A rapid method for preparation of the cerebrospinal fluid proteome" good read http://t.co/w0Xn2KZhLY
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Scooped by Gilbert C FAURE
October 17, 2014 10:45 AM
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Neuroimmunology: Disease mechanisms in narcolepsy remain elusive - Nature.com

Neuroimmunology: Disease mechanisms in narcolepsy remain elusive
Nature.com
A pandemic influenza vaccine with a specific type of vaccine antigen has been linked to an increased incidence of narcolepsy in children from 2009–2010.
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Scooped by Gilbert C FAURE
October 14, 2014 2:04 PM
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A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease

A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease | NeuroImmunology | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Scooped by Gilbert C FAURE
October 13, 2014 2:43 PM
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Analysis of CD4+ CD8+ double-positive T cel... [Clin Exp Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
October 12, 2014 2:16 PM
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New Technique Offers Faster, More Accurate Way to Count Brain Cells - Wall Street Journal

New Technique Offers Faster, More Accurate Way to Count Brain Cells - Wall Street Journal | NeuroImmunology | Scoop.it
A Brazilian researcher has pioneered a fast and accurate technique for counting brain cells, a task vital to explaining how humans differ from other animals.
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Scooped by Gilbert C FAURE
October 10, 2014 5:56 AM
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Multiple sclerosis Blood-based biomarkers provide insight into progressive MS - Nature.com

Multiple sclerosis Blood-based biomarkers provide insight into progressive MS Nature.com Benjamin Segal and co-workers analysed peripheral mononuclear cells that produce IL-17 and IFN-γ, and proinflammatory factors in plasma from patients with...
Gilbert C FAURE's insight:

According to two studies published recently in Neurology, biomarkers in blood could distinguish between the different clinical phenotypes of multiple sclerosis (MS), and elucidate the role of inflammation in progressive MS.

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