NeuroImmunology
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Terry Pratchett Death From Alzheimer's: Quotes To Remember 'Discworld ... - International Business Times

Terry Pratchett Death From Alzheimer's: Quotes To Remember 'Discworld ... - International Business Times | NeuroImmunology | Scoop.it
"In ancient times, cats were worshipped as gods. They have never forgotten this."
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Multiple Sclerosis--the vascular connection: 2015 ISNVD Conference Abstracts---research breakdown

Multiple Sclerosis--the vascular connection: 2015 ISNVD Conference Abstracts---research breakdown | NeuroImmunology | Scoop.it
RT Multiple Sclerosis--the vascular connection: 2015 ISNVD Conference Abstracts---research breakdown http://t.co/nnyoyVHeCe
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Surprising finding provides more support for Alzheimer's being an autoimmune disease - PsyPost

Surprising finding provides more support for Alzheimer's being an autoimmune disease - PsyPost | NeuroImmunology | Scoop.it
Brain levels of the lipid ceramide are high in Alzheimer's disease, and now scientists have found increased levels of an antibody to the lipid in their dis ...
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March 13, 2015 4:45 PM
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Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

Abstract

 

After stimulation, dendritic cells (DCs) mature and migrate to draining lymph nodes to induce immune responses1. As such, autologous DCs generated ex vivo have been pulsed with tumour antigens and injected back into patients as immunotherapy. While DC vaccines have shown limited promise in the treatment of patients with advanced cancers2, 3, 4 including glioblastoma5, 6, 7, the factors dictating DC vaccine efficacy remain poorly understood. Here we show that pre-conditioning the vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and efficacy of tumour-antigen-specific DCs. To assess the effect of vaccine site pre-conditioning in humans, we randomized patients with glioblastoma to pre-conditioning with either mature DCs8 or Td unilaterally before bilateral vaccination with DCs pulsed with Cytomegalovirus phosphoprotein 65 (pp65) RNA. We and other laboratories have shown that pp65 is expressed in more than 90% of glioblastoma specimens but not in surrounding normal brain9, 10, 11, 12, providing an unparalleled opportunity to subvert this viral protein as a tumour-specific target. Patients given Td had enhanced DC migration bilaterally and significantly improved survival. In mice, Td pre-conditioning also enhanced bilateral DC migration and suppressed tumour growth in a manner dependent on the chemokine CCL3. Our clinical studies and corroborating investigations in mice suggest that pre-conditioning with a potent recall antigen may represent a viable strategy to improve anti-tumour immunotherapy.


Via Krishan Maggon
Krishan Maggon 's curator insight, March 12, 2015 2:41 AM

NATURE | LETTER

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patientsDuane A. Mitchell,Kristen A. Batich,Michael D. Gunn,Min-Nung Huang,Luis Sanchez-Perez,Smita K. Nair,Kendra L. Congdon,Elizabeth A. Reap,Gary E. Archer,Annick Desjardins,Allan H. Friedman,Henry S. Friedman,James E. Herndon II,April Coan,Roger E. McLendon,David A. Reardon,James J. Vredenburgh,Darell D. Bigner& John H. SampsonAffiliationsContributionsCorresponding authorsNature (2015) doi:10.1038/nature14320Received 06 December 2013 Accepted 13 February 2015 Published online 11 March 2015

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Choroid plexus dysfunction impairs beta-amyloid clearance in a trip... - PubMed - NCBI

Front Cell Neurosci. 2015 Feb 6;9:17. doi: 10.3389/fncel.2015.00017. eCollection 2015.
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March 11, 2015 2:53 PM
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Endothelial-Mesenchymal Transition of Brain Endothelial Cells: Possible Role during Metastatic Extravasation

Endothelial-Mesenchymal Transition of Brain Endothelial Cells: Possible Role during Metastatic Extravasation | NeuroImmunology | Scoop.it
by István A. Krizbai, Ákos Gasparics, Péter Nagyőszi, Csilla Fazakas, Judit Molnár, Imola Wilhelm, Rita Bencs, László Rosivall, Attila Sebe Cancer progression towards metastasis follows a defined sequence of events described as the metastatic...
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Neuroimmunology Branch Repository - Full Text View - ClinicalTrials.gov

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New Research on Immunology of the Cerebrospinal Fluid Compartment and MS - YouTube

This MS research webcast reviews immune surveillance and its application to the central nervous system. To learn more about the Multiple Sclerosis Virtual Gr...
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also CME

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March 7, 2015 2:54 PM
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Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease | NeuroImmunology | Scoop.it

The present study explored the extent and characteristics of intraneuronal amyloid-β accumulation, particularly of the fibrillogenic 42-amino acid isoform, within basal forebrain cholinergic neurons in normal young, normal aged and Alzheimer’s disease brains as a potential contributor to the selective vulnerability of these neurons using immunohistochemistry and western blot analysis. Amyloid-β1–42immunoreactivity was observed in the entire cholinergic neuronal population regardless of age or Alzheimer’s disease diagnosis. The magnitude of this accumulation as revealed by optical density measures was significantly greater than that in cortical pyramidal neurons, and magnocellular neurons in the globus pallidus did not demonstrate a similar extent of amyloid immunoreactivity. Immunoblot analysis with a panel of amyloid-β antibodies confirmed accumulation of high concentration of amyloid-β in basal forebrain early in adult life. There was no age- or Alzheimer-related alteration in total amyloid-β content within this region. In contrast, an increase in the large molecular weight soluble oligomer species was observed with a highly oligomer-specific antibody in aged and Alzheimer brains when compared with the young. Similarly, intermediate molecular weight oligomeric species displayed an increase in aged and Alzheimer brains when compared with the young using two amyloid-β42 antibodies. Compared to cortical homogenates, small molecular weight oligomeric species were lower and intermediate species were enriched in basal forebrain in ageing and Alzheimer’s disease. Regional and age-related differences in accumulation were not the result of alterations in expression of the amyloid precursor protein, as confirmed by both immunostaining and western blot. Our results demonstrate that intraneuronal amyloid-β accumulation is a relatively selective trait of basal forebrain cholinergic neurons early in adult life, and increases in the prevalence of intermediate and large oligomeric assembly states are associated with both ageing and Alzheimer’s disease. Selective intraneuronal amyloid-β accumulation in adult life and oligomerization during the ageing process are potential contributors to the degeneration of basal forebrain cholinergic neurons in Alzheimer’s disease.


Via Krishan Maggon
Krishan Maggon 's curator insight, March 3, 2015 11:55 AM

Beta amyloid was detected in younger brains 20 yr of age.

 

 

Brain  

 

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

 

Alaina Baker-Nigh , Shahrooz Vahedi , Elena Goetz Davis , Sandra Weintraub , Eileen H. Bigio , William L. Klein , Changiz GeulaDOI: http://dx.doi.org/10.1093/brain/awv024 First published online: 2 March 2015
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Frontiers | Transport of thyroid hormones via the choroid plexus into the brain: the roles of transthyretin and thyroid hormone transmembrane transporters | Neurogenomics

Thyroid hormones (THs) are key players in regulating brain development. In humans, insufficient THs during gestation can lead to cretinism and mental retardation. Thus, transfer of appropriate quan...
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Alzheimer's Disease Amyloid Plaques Build Over A Lifetime; Found In Brains As ... - Medical Daily

Alzheimer's Disease Amyloid Plaques Build Over A Lifetime; Found In Brains As ... - Medical Daily | NeuroImmunology | Scoop.it
Alzheimer's markers found in young adults show how the disease builds overtime.
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March 4, 2015 3:35 PM
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Emerging role of IL-16 in cytokine-mediated regulation of multiple sclerosis

REVIEW| Emerging Role of IL-16 in Cytokine-Mediated Regulation of #MultipleSclerosis http://t.co/WrFifcvBSK
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March 4, 2015 5:12 AM
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New Clinical Trial for Glioblastoma Treatment Uses Immunotherapy - Immuno-Oncology News

New Clinical Trial for Glioblastoma Treatment Uses Immunotherapy - Immuno-Oncology News | NeuroImmunology | Scoop.it
Read how a New Clinical Trial for Glioblastoma Treatment Uses Immunotherapy
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PLEGRIDY (peginterferon beta-1a) receives SMC approval for the treatment of relapsing remitting multiple sclerosis

PLEGRIDY (peginterferon beta-1a) receives SMC approval for the treatment of relapsing remitting multiple sclerosis | NeuroImmunology | Scoop.it
PLEGRIDY® (peginterferon beta-1a) has been approved by the Scottish Medicines Consortium (SMC) as a treatment for adults with relapsing- remitting multiple sclerosis (RRMS).1 Peginterferon beta-1a is the only approved pegylated treatment for MS.
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Programme Details | BNA2015: Festival of Neuroscience

Programme Details | BNA2015: Festival of Neuroscience | NeuroImmunology | Scoop.it
Thinking of multiple sclerosis neurodegenerative pathology in a regenerative way #brains #neuroscience #2015neurofest http://t.co/EZkJx1LvcC
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March 14, 2015 6:44 AM
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STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior : Scientific Reports : Nature Publishing Group

STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior : Scientific Reports : Nature Publishing Group | NeuroImmunology | Scoop.it
Experimental evidence suggests a role for the immune system in the pathophysiology of depression.

Via Krishan Maggon
Krishan Maggon 's curator insight, March 13, 2015 8:45 AM

SCIENTIFIC REPORTS | ARTICLE OPEN

PrintShare/bookmark STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behaviorEryan Kong,Sonja Sucic,Francisco J. Monje,Giorgia Savalli,Weifei Diao,Deeba Khan,Marianne Ronovsky,Maureen Cabatic,Florian Koban,Michael Freissmuth& Daniela D. PollakAffiliationsContributionsCorresponding authorScientific Reports 5, Article number: 9009 doi:10.1038/srep09009Received 23 September 2014 Accepted 11 February 2015 Published 11 March 2015

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Expression of Regulatory Proteins in Choroid Plexus Changes in Earl... - PubMed - NCBI

J Neuropathol Exp Neurol. 2015 Mar 9. [Epub ahead of print]
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The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations. - PubMed - NCBI

J Neuroinflammation. 2015 Jan 28;12(1):19. [Epub ahead of print]
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March 9, 2015 9:13 AM
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A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: Overview

A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: Overview: Background... http://t.co/UAsEfrvUGv
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Big Data Portal Launches for Alzheimer's Drug Discovery - Scientific Computing

Big Data Portal Launches for Alzheimer's Drug Discovery - Scientific Computing | NeuroImmunology | Scoop.it
A National Institutes of Health-led public-private partnership to transform and accelerate drug development achieved a significant milestone recently with the launch of a new Alzheimer’s Big Data portal — including delivery of the first wave of data...
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Peculiar Cytological Cerebrospinal Fluid Pattern in a Case of Encephalomyelitis During Anti-Tumor Necrosis Factor-α Therapy - Online First - Springer

Peculiar Cytological Cerebrospinal Fluid Pattern in a Case of Encephalomyelitis During Anti-Tumor Necrosis Factor-α Therapy - Online First - Springer | NeuroImmunology | Scoop.it
Online now in Neurology and Therapy:...Cytological Cerebrospinal Fluid Pattern in a Case of #Encephalomyelitis... http://t.co/gMHpkfJwFR #OA
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Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial ce... - PubMed - NCBI

Nat Commun. 2015 Feb 27;6:6366. doi: 10.1038/ncomms7366.
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Treatment of Late-Stage Syphilis - JAMA: The Journal of the American Medical Association

Treatment of Late-Stage Syphilis - JAMA:  The Journal of the American Medical Association | NeuroImmunology | Scoop.it
To the Editor Dr Clement and colleagues1 reviewed the available literature on treatment for the early and late stages of syphilis and concluded that benzathine penicillin G is the established treatment for early syphilis (grade A level of evidence).
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Brain Protein Tied to Alzheimer's Spotted in Young Adults - U.S. News & World Report

Brain Protein Tied to Alzheimer's Spotted in Young Adults - U.S. News & World Report | NeuroImmunology | Scoop.it
People as young as 20 have amyloid buildup, but researchers aren't sure what it means
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'Miracle' stem cell treatment reboots immune system in MS - NHS Choices

'Miracle' stem cell treatment reboots immune system in MS - NHS Choices | NeuroImmunology | Scoop.it
The Daily Telegraph reports a “miracle” stem cell therapy that reverses multiple sclerosis and which, according to The Sunday Times, gets “wheelchair-bound” people dancing...
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