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INNOTEST@PHOSPHO-TAU for the quantitative determination of phosphorylated in human cerebrospinal fluid http://t.co/msFgtGXgoo 
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Acta Neuropathol. 2015 Feb 26. [Epub ahead of print]
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IL-15 Amplifies the Pathogenic Properties of CD4+CD28- T Cells in Multiple Sclerosis [AUTOIMMUNITY] http://t.co/OnxRsKXl3T #jimmTCB
Krishan Maggon 's curator insight,
March 4, 2015 3:35 AM
Published online before printJanuary 23, 2015, doi:10.4049/jimmunol.1401547The Journal of ImmunologyMarch 1, 2015vol. 194 no. 5 2099-2109IL-15 Amplifies the Pathogenic Properties of CD4+CD28− T Cells in Multiple SclerosisBieke Broux*, Mark R. Mizee†, Marjan Vanheusden*, Susanne van der Pol†,Jack van Horssen*,†, Bart Van Wijmeersch*,‡, Veerle Somers*, Helga E. de Vries†,Piet Stinissen* and Niels Hellings*
+Author Affiliations *Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium;†Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1081 BT Amsterdam, the Netherlands; and‡Revalidatie en MS-Centrum, 3900 Overpelt, BelgiumAddress correspondence and reprint requests to Prof. Niels Hellings, Biomedical Research Institute, Agoralaan, Building C, 3590 Diepenbeek, Belgium. E-mail address:niels.hellings@uhasselt.be
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"Pathways of cerebrospinal fluid outflow: a deeper understanding of resorption" http://t.co/4uubP3FSZB #springerlink
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Source: msj.sagepub.com#MultipleSclerosisAwarenessWeekSee on Scoop.it - Overcoming Multiple Sclerosis
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Abstract Alzheimer's disease (AD) is the world's most common dementing illness, affecting over 150 million patients. Classically AD has been viewed as a neurodegenerative disease of the elderly, characterized by the extracellular deposition of misfolded amyloid-β (Aβ) peptide and the intracellular formation of neurofibrillary tangles. Only recently has neuroinflammation emerged as an important component of AD pathology. Experimental, genetic and epidemiological data now indicate a crucial role for activation of the innate immune system as a disease-promoting factor. The sustained formation and deposition of Aβ aggregates causes chronic activation of the immune system and disturbance of microglial clearance functions. Here we review advances in the molecular understanding of the inflammatory response in AD that point to novel therapeutic approaches for the treatment of this devastating disease. Via Krishan Maggon
Krishan Maggon 's curator insight,
March 2, 2015 2:10 AM
NATURE IMMUNOLOGY | REVIEW Innate immunity in Alzheimer's diseaseMichael T Heneka,Douglas T Golenbock& Eicke LatzAffiliationsCorresponding authorNature Immunology 16, 229–236 (2015) doi:10.1038/ni.3102Received 03 December 2014 Accepted 13 January 2015 Published online 17 February 2015
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Practical Management of Bevacizumab-Related Toxicities in Glioblastoma
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by Michael Safaee, Shayan Fakurnejad, Orin Bloch, Aaron J. Clark, Michael E. Ivan, Matthew Z. Sun, Taemin Oh, Joanna J. Phillips, Andrew T.
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I've just posted on my Blog about: Producing oligodendrocytes with SOX http://t.co/sIOqBKHfa3
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Suppressor of cytokine signaling 1 (SOCS1) is a key regulator of cytokines signaling and plays the most important... http://t.co/x3IThhbzOM
Krishan Maggon 's curator insight,
February 24, 2015 12:02 AM
Expression of suppressor of cytokine signaling 1 (SOCS1) gene dramatically increases in relapsing–remitting multiple sclerosisMajid Pahlevan Kakhki, Nahid Rakhshi, Masoumeh Heidary, Mehrdad Behmanesh, Abbas NikraveshReceived: November 17, 2014; Received in revised form: January 29, 2015; Accepted: February 2, 2015; Published Online:February 07, 2015DOI: http://dx.doi.org/10.1016/j.jns.2015.02.005Publication stage: In Press Corrected Proof
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Starting at the Royal Free Hospital School of Medicine in 1977, and moving to the University of Oxford, UK, in 1988, the Vincent Neuroimmunology Group was created to understand the mechanisms underlying nerve and muscle diseases.
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Front Oncol. 2015 Jan 29;5:12. doi: 10.3389/fonc.2015.00012. eCollection 2015. Immunotherapeutic advancements for glioblastoma. Ampie L1, Woolf EC1, Dardis C1.
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Our susceptibility to disease depends both on the genes that we inherit from our parents and on our lifetime experiences.
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IFN-β remains the most widely prescribed treatment for relapsing remitting multiple sclerosis. Despite widespread use of IFN-β, the therapeutic mechanism is still partially understood.
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by Steffan D. Bos, Christian M. Page, Bettina K. Andreassen, Emon Elboudwarej, Marte W. Gustavsen, Farren Briggs, Hong Quach, Ingvild S. Leikfoss, Anja Bjølgerud, Tone Berge, Hanne F. Harbo, Lisa F.
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A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis: Background:
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Background Glioblastoma is the most common and most lethal form of brain tumor in human. Unfortunately, there is still no effective therapy to this fatal disease and the median survival is generally less than one year from the time of diagnosis.
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Tackling brain inflammation ameliorates Alzheimer's disease (AD), according to a study published in The Journal of Experimental Medicine.
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Objectives The purpose of this study was to carry out systematic review of the literature and meta-analysis to evaluate the diagnostic utility of cerebrospinal fluid (CSF) levels of the 42 amino acid form of amyloid-beta (Aβ 1–42 ) as a biomarker...
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Researchers are trying to develop ways to more quickly and accurately diagnose Alzheimer’s, which might lead to better treatments and understanding in the future Via Krishan Maggon
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Immune cells drive resilience
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J Neuroimmunol. 2014 Dec 15;277(1-2):153-9. doi: 10.1016/j.jneuroim.2014.10.005. Epub 2014 Oct 18. Research Support, Non-U.S. Gov't
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J Immunol Res. 2014;2014:796856. doi: 10.1155/2014/796856. Epub 2014 Apr 3. Current vaccine trials in glioblastoma: a review. Xu LW1, Chow KK1, Lim M2, Li G1.
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Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. http://t.co/9QQPHetYDB
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