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A critical appraisal of daclizumab use as emerging therapy in multiple sclerosis http://t.co/iyRnRnfa4A
Introduction: Daclizumab (DAC) is a mAb that binds to CD25, a receptor on the surface of lymphocytes for IL-2, a chemical messenger in the immune system. This prevents activation and proliferation of lymphocytes, which are involved in the immune attack in multiple sclerosis (MS).
Areas covered: In this review, we will focus on newly emerging DAC-high-yield process (HYP) therapy for MS. Based on published original articles and citable meeting abstracts, we will discuss its mode of action as well as data on efficacy and safety.
Expert opinion: DAC has been observed to have multiple (biological) effects, which may contribute to beneficial effects in immune-related disease and particularly in relapsing-remitting MS. The positive results in the clinical studies represent achievement of an important milestone in the development of DAC-HYP as a potential new treatment option for MS patients. The benefit/risk ratios of this new biological agent in MS therapy are still being evaluated. Soon, DAC-HYP might qualify as MS therapy. A safety monitoring program is recommended in the clinical practice.
Via Krishan Maggon
Expert Opinion on Drug Safety
Drug Safety Evaluation
A critical appraisal of daclizumab use as emerging therapy in multiple sclerosis
Emanuele D’Amico, Silvia Messina, Cinzia Caserta, and Francesco Patti1RKU - Universitäts- und Rehabilitationskliniken Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany2Centro Sclerosi Multipla, Dipartimento di Neurologia, via Santa Sofia, 78 Catania, Italy3Universita´degli Studi di Catania, Dipartimento di Neurologia, via Santa Sofia, 78 Catania, Italy patti@unict.it