Prevention of central nervous system (CNS) relapse is critical for cure of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
NeuroImmunology
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Experimental autoimmune encephalomyelitis (EAE) is an animal model of demyelinating autoimmune disease, such as multiple sclerosis (MS), which is characterized by central nervous system white matter lesions, microglial activation, and peripheral...
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The blood-brain barrier has stymied direct treatment of brain disorders. In a recently published study, a researcher reports finding a way to pass therapeutics through the barrier, using readily-available agents.
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Vesicles containing neurotransmitters at synapses are well known, but mechanisms explaining their speed are still not clear.
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High-grade glioma is the most aggressive form of brain cancer. Despite improvements in surgical procedures, chemotherapy, and radiotherapy, this type of brain tumour is still notoriously hard to treat: less than 10% of patients survive beyond five years. Researchers from KU Leuven, Belgium, have now shown that next-generation cell-based immunotherapy may offer new hope in the fight against brain cancer. Cell-based immunotherapy involves the injection of a therapeutic anticancer vaccine that stimulates the patient’s immune system to attack the tumour. Thus far, the results of this type of immunotherapy have been mildly promising. However, Abhishek D. Garg and Professor Patrizia
Via Krishan Maggon
Riley Norton's curator insight,
December 9, 2018 3:59 PM
Using the Dendritic Cell Immuniotherapy in mice, researchers were able to cure at least 50% of the mice with cancer.
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Can we modify the intrathecal B cell and plasma cell biology?
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Glatigny S, Wagner CA, Bettelli E. Cutting Edge: Integrin α4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis. J Immunol. 2016. pii: 1502614.
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The complement system, which forms part of our immune system, is involved in a special form of epilepsy. This is the conclusion of a recently published single-case study.
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Neuroscience News has recent neuroscience research articles, brain research news, neurology studies and neuroscience resources for neuroscientists, students, and science fans and is always free to join.
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Around 7–17% of metastatic breast cancer patients will develop brain metastases, associated with a poor prognosis. To reach the brain parenchyma, cancer cells need to cross the highly restrictive endothelium of the Blood-Brain Barrier (BBB).
Gilbert C FAURE's insight:
for CSFTCs
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Researchers report the first successful use of this technology to detect soluble Aβ in the brains of Alzheimer’s mouse models.
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ConclusionImmunological treatment of suggested AB‐negative LE showed reasonable seizure control, MRI and cognitive improvements.
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Source: The Science Behind WeCureALZ: A Participatory Research Project Tackling Alzheimer’s Disease Image Credit: Human Computation Institute CC-BY-NC-SA 4.0, Graphic by PachecoDesignlab.com by Egle Marija Ramanauskaite Earlier this year, we...
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Frontotemporal dementia (FTD), the second most common cause of dementia in people under 65, may be triggered by a defect in immune cells called microglia that causes them to consume the brain’s synaptic connections, according to new research led by...
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Objective
Many JC virus antibody-positive relapsing–remitting multiple sclerosis (RRMS) patients who are stable on natalizumab switch to other therapies to avoid progressive multifocal leukoencephalopathy.
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Correspondence from The New England Journal of Medicine — Multiple Sclerosis and Antibodies against KIR4.1
Gilbert C FAURE's insight:
KIR4 down
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Complement and microglia mediate early synapse loss in Alzheimer mouse models | Science https://t.co/L5KrwH9qmy
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Gilbert C FAURE's insight:
Calliope A. Dendrou, Robin J. Franklin and Lars Fugger
Multiple sclerosis (MS) is a neuroinflammatory condition that affects the central nervous system and presents with various neurological and cognitive symptoms. Although these symptoms and the disease course of MS can vary considerably among affected individuals, most people with this condition exhibit a progressive accumulation of disability in the later phase of the disease. This poster provides an overview of the pathophysiological contributions of both the immune system and the nervous system to MS and how these contributions change with disease progression. The poster also highlights the sites of action of the currently available drugs for MS and briefly touches on other therapeutic strategies that are being explored.
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Neuroscience News has recent neuroscience research articles, brain research news, neurology studies and neuroscience resources for neuroscientists, students, and science fans and is always free to join.
Claire Dubois's curator insight,
November 7, 2022 11:54 AM
Tous ses articles sur les potentielles thérapies à venir donnent bcp d’espoir mais parfois on en vient à se demander si toutes ces pistes meneront un jour à un traitement.
Ici on peut se rendre compte à quel point la SLA est une maladie compliquée à comprendre : on voit que la mutation du gène C9orf72 serait responsable uniquement de 10% des cas. Il faut donc trouver la cause des 90% restants.
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Circulating memory T follicular helper subsets, Tfh2 and Tfh17 are found to be aberrantly regulated in many autoimmune diseases. Via Marcelo de Carvalho Bittencourt
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The immune system is involved in the development of neuropathic pain. In particular, the infiltration of T-lymphocytes into the spinal cord following peripheral nerve injury has been described as a contributor to sensory hypersensitivity.
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An emerging concept of normal brain immune surveillance proposes that recently and moderately activated central memory T lymphocytes enter the central nervous system (CNS) directly into the cerebrospinal fluid (CSF) via the choroid plexus.
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