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Scooped by
Gilbert C FAURE
August 24, 2021 2:43 PM
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Cord blood CRTh2high ILC2 populations from infants born to asthmatic mothers may influence lung function later in life. The association between cord blood CRTh2high ILC2 and foetal eosinophil
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Suggested by
LIGHTING
August 22, 2021 1:33 PM
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�Superbe étude sur l’atteinte de l’épithelium respiratoire et des cellules ciliées de celui-ci par le SARS-CoV-2 ��
▶️ Rémy Robinot et al, Nature Communications...���
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Scooped by
Gilbert C FAURE
August 7, 2021 12:05 PM
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Thai virologists at BIOTEC have 2 nasal spray options currently in development that may act as a substitute for Covid-19 vaccines in needle form.
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Scooped by
Gilbert C FAURE
August 7, 2021 2:38 AM
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SARS-CoV-2 infection induces strong type I IFN immunity in the nasopharyngeal cavity of mildly symptomatic COVID-19 patients, but this response is compromised i...
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Scooped by
Gilbert C FAURE
August 3, 2021 6:50 AM
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Human adenoviruses cause disease at multiple mucosal sites, including the respiratory, gastrointestinal, and genitourinary tracts, and are common agents of conjunctivitis. One site of infection that has received sparse attention is the cornea, a transparent tissue and the window of the eye. While most adenovirus infections are self-limited, corneal inflammation (keratitis) due to adenovirus can persist or recur for months to years after infection, leading to reduced vision, discomfort, and light sensitivity. Topical corticosteroids effectively suppress late adenovirus keratitis but are associated with vision-threatening side effects. In this short review, we summarize current knowledge on infection of the cornea by adenoviruses, including corneal epithelial cell receptors and determinants of corneal tropism. We briefly discuss mechanisms of stromal keratitis due to adenovirus infection, and review an emerging therapy to mitigate adenovirus corneal infections based on evolving knowledge of corneal epithelial receptor usage.
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Scooped by
Gilbert C FAURE
August 2, 2021 3:59 AM
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medRxiv - The Preprint Server for Health Sciences...
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Scooped by
Gilbert C FAURE
August 2, 2021 3:58 AM
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Abstract Twenty-five years ago the field was revolutionized by the introduction of infliximab as the first hybrid anti-TNF-antibody. Subsequently, other humanized anti-TNFs were developed and marke...
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Scooped by
Gilbert C FAURE
August 2, 2021 3:56 AM
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The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to scale up around the world, costing severe health and economic losses.
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Scooped by
Gilbert C FAURE
August 2, 2021 3:54 AM
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Biological redundancy ensures robustness in living organisms at several levels, from genes to organs. In this review, we explore the concept of redundancy and robustness through an analysis of the caecal appendix, an organ that is often considered to be a redundant remnant of evolution.
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Scooped by
Gilbert C FAURE
July 27, 2021 11:31 AM
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Scooped by
Gilbert C FAURE
July 26, 2021 3:47 AM
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Using flow cytometry analysis we showed greater phagocytic activity of sputum neutrophils compared to sputum macrophages in COPD patients and smoking and non-smoking controls. While we showed som
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Scooped by
Gilbert C FAURE
July 12, 2021 1:42 PM
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Mucosal-associated invariant T (MAIT) cells are a subset of T lymphocytes expressing a semi-invariant T-cell receptor (TCR) present as TCR Vα7.2-Jα33 in humans and TCR Vα19-Jα33 in mice. They are activated by ligands produced during microbial biosynthesis of riboflavin that is presented by major...
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Scooped by
Gilbert C FAURE
July 7, 2021 4:27 AM
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A dysregulated overly exuberant immune response, termed a "cytokine storm," accompanies virus-induced acute respiratory diseases (VARV), is primarily responsible for the accompanying high morbidity and mortality, and can be controlled therapeutically in influenza virus infection of mice and ferrets...
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Scooped by
Gilbert C FAURE
August 24, 2021 5:41 AM
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A central goal of microbiome research is to understand the factors that balance gut-associated microbial communities, thereby creating longitudinal an…
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Suggested by
LIGHTING
August 9, 2021 2:00 PM
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Tissue-resident memory T (TRM) cells critically contribute to the rapid immunoprotection and efficient immunosurveillance against pathogens, particularly in barrier tissues, but also during anti-tumor responses. However, the involvement of TRM cells also in the induction and exacerbation of immunopathologies, notably in chronically relapsing auto-inflammatory disorders, is becoming increasingly recognized as a critical factor. Thus, TRM cells may also represent an attractive target in the management of chronic (auto-) inflammatory disorders, including multiple sclerosis, rheumatoid arthritis, celiac disease and inflammatory bowel diseases. In this review, we focus on current concepts of TRM cell biology, particularly in the intestine, and discuss recent findings on their involvement in chronic relapsing–remitting inflammatory disorders. Potential therapeutic strategies to interfere with these TRM cell-mediated immunopathologies are discussed.
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Scooped by
Gilbert C FAURE
August 7, 2021 12:04 PM
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The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global concern. Immunoglobin A (IgA) contributes to virus neutralization at the early stage of infection. Longitudinal studies are needed to assess whether SARS-CoV-2-specific IgA production persists for a...
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Scooped by
Gilbert C FAURE
August 4, 2021 2:08 PM
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Scientists from Germany and Italy recently demonstrated the benefits of intramuscular/intranasal heterologous prime-boost vaccination regimen against coronavirus disease 2019 (COVID-19).
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Scooped by
Gilbert C FAURE
August 2, 2021 4:00 AM
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Abstract: Without reliable measures of prevalence (viral circulation) and severity (the probability that infections lead to severe forms such as hospitalisation), the medium-term impact of viral…...
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Scooped by
Gilbert C FAURE
August 2, 2021 3:58 AM
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Mucosal vaccines offer the potential to trigger robust protective immune responses at the predominant sites of pathogen infection. In principle, the induction of adaptive immunity at mucosal sites, involving secretory antibody responses and tissue-resident T cells, has the capacity to prevent an...
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Scooped by
Gilbert C FAURE
August 2, 2021 3:56 AM
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Amid concerns over a possible third wave of the coronavirus pandemic and to speed up the vaccination process in the country, an expert panel of India's central drug authority has recommended giving an approval to Bharat Biotech to carry out a study on interchangeability of its Covaxin and the...
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Scooped by
Gilbert C FAURE
August 2, 2021 3:55 AM
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Peptic ulcer refers to the inflammatory response and necrotic lesions of the mucosa under the action of various pathogenic factors, which goes deeply into the mucosal muscle layer and often occurs to the gastrointestinal mucosa related to gastric acid ...
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Scooped by
Gilbert C FAURE
July 31, 2021 12:43 PM
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Hassan et al. show that immunization with ChAd-SARS-CoV-2-S is durably immunogenic
and protects against SARS-CoV-2 challenge in a dose-dependent manner. Many months
after single-dose intranasal immunization, ChAd-SARS-CoV-2 confers protection against
variants of concerns of SARS-CoV-2 in both the upper and lower respiratory tracts
of mice.
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Scooped by
Gilbert C FAURE
July 26, 2021 11:51 AM
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Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal inflammation of unknown cause encompassing Crohn’s disease (CD) and ulcerative colitis (UC). IBD has been linked to genetic and environmental factors, microbiota dysbiosis, exacerbated innate and adaptive immunity and...
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Scooped by
Gilbert C FAURE
July 26, 2021 2:26 AM
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Scooped by
Gilbert C FAURE
July 8, 2021 1:38 PM
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Prof O’Mahony began by discussing how the human gut is colonised by a wide diversity of microbes. He went on to review the evidence for how the
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