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#BIOL230, check out my stained buccal mucosa (human inner-cheek) cells at 400X magnification pic.twitter.com/BhOstdoxb1
Gilbert C FAURE's insight:
good to see college students discovering cells by themselves
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by Ning Qin, Xian-Cong Fan, Xiao-Xing Xu, Thobela Louis Tyasi, Shi-Jun Li, Ying-Ying Zhang, Man-Li Wei, Ri-Fu Xu Forkhead box L2 (FOXL2) is a member of the forkhead nuclear factor 3 gene family and plays an essential role in ovarian growth and...
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Mucosal immunology Battle scars
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by Hweh Fen Goh, Koshy Philip
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Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues. The journal reflects the interests of scientists studying gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through the publication of original research articles, scholarly reviews, and timely commentaries, editorials and letters.
Gilbert C FAURE's insight:
Human milk contains nutrients and bioactive products relevant to infant development and immunological protection. Here, we investigated the proresolving properties of milk using human milk lipid mediator isolates (HLMIs) and determined their impact on resolution programs in vivo and with human macrophages. HLMIs reduced the maximum neutrophil numbers (14.6±1.2 × 106–11.0±1.0 × 106 cells per exudate) and shortened the resolution interval (Ri; 50% neutrophil reduction) by 54%compared with peritonitis. Using rigorous liquid-chromatography tandem-mass spectrometry (LC-MS-MS)-based lipid mediator (LM) metabololipidomics, we demonstrated that human milk possesses a proresolving LM-specialized proresolving mediator (LM-SPM) signature profile, containing SPMs (e.g. resolvins (Rv), protectins (PDs), maresins (MaRs), and lipoxins (LXs)) at bioactive levels (pico-nanomolar concentrations) that enhanced human macrophage efferocytosis and bacterial containment. SPMs identified in human milk included D-series Rvs (e.g., RvD1, RvD2, RvD3, AT-RvD3, and RvD4), PD1, MaR1, E-series Rvs (e.g. RvE1, RvE2, and RvE3), and LXs (LXA4 and LXB4). Of the SPMs identified in human milk, RvD2 and MaR1 (50 ng per mouse) individually shortened Ri by ~75%. Milk from mastitis gave higher leukotriene B4 and prostanoids and lower SPM levels. Taken together, these findings provide evidence that human milk has proresolving actions via comprehensive LM-SPM profiling, describing a potentially novel mechanism in maternal–infant biochemical imprinting.
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Inactivated poliovirus vaccine (IPV) may be used in mass vaccination campaigns during the final stages of polio eradication.
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Innate Lymphoid Cells - Couch Potatoes! http://t.co/98jRJbf22K #immunity #inflammation #innateimmunity @sciencemagazine
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Cell Mol Life Sci. 2015 Oct 12. [Epub ahead of print]
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by Minghao Chen, Shiyou Wei, Junyan Hu, Song Quan Objective To examine whether comprehensive chromosome screening (CCS) for preimplantation genetic screening (PGS) has an effect on improving in vitro fertilization/intracytoplasmic sperm injection...
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Nature.com Immunology: A bacterial nudge to T-cell function Nature.com They show that SFB bolster SAA expression through a roundabout route involving innate lymphoid cells (ILCs), a group of immune cells that are related to T cells but distinct in...
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Mucosal immunity and upper respiratory tract symptoms in runners. Our latest paper now online:
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Nature.com
Gilbert C FAURE's insight:
According to new research published in Cell, short-term changes in diet can regulate gut motility. This effect correlated with changes in the levels of unconjugated bile acids. Turmeric, a spice prevalent in Bangledeshi cuisine, was shown to affect gut motility via cholekinesis, which was modulated by bacterial bile salt hydrolase…
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From
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Cars appear to produce carbon nanotubes, and some of the evidence has been found in human lungs.
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Oncogenesis is a peer-reviewed open access online journal that publishes full-length papers exploring the molecular basis of cancer and related phenomena.
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A new strategy has been developed to determine monocyte subsets involved in diseases. The results could help facilitating the diagnosis of sarcoidosis and may improve the respective patient management.
Gilbert C FAURE's insight:
CD16 monocytes?
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Read how Levels of the Immune Cytokine Interleukin 37 Raised in Endometriosis
auriane.caer@gmail.com's curator insight,
December 1, 2022 9:52 AM
Il pourrait être intéressant de se pencher davantage sur le rôle d'IL37 dans les processus inflammatoires impliqués dans l'endométriose.
Eva Munch's curator insight,
December 22, 2022 6:55 AM
Cette étude met en évidence une expression et des taux majorés de l'IL-37 chez un groupe de femmes atteintes d'endométriose.
L'IL-37 est une interleukin-9 particulière car son rôle principal est d'inhiber le système immunitaire avec des effets anti inflammatoires. Il serait donc pertinent de poursuivre les recherches afin d'objectiver le rôle de l'IL-37 dans le processus pathologique à l'origine de l'endométriose.
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by Wen Kong, Xun Niu, Tianshu Zeng, Meixia Lu, Lulu Chen Background Metformin is effective for the treatment of polycystic ovary syndrome, but conflicting results regarding its effect on adipocytokine levels (adiponectin, resistin, visfatin, and...
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Interaction of Menstrual Cycle Phase & Sexual Activity Predicts Mucosal & Systemic Humoral Immunity in Healthy Women http://t.co/Tn6NZEIe5t
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Inflammatory bowel disease (IBD) is a chronic and multifactorial disease of the gastrointestinal tract. The exact etiology of IBD remains complex and unclear involving an inadequately defined relationship between microbial insult, genetic predisposition, altered intestinal barrier permeability, oxidative stress components and abnormal immune responses. The role of the co-stimulatory system made up of cluster of differentiation 40 protein (CD40) and its ligand (CD40L) in the response of the immune system to pathogens is now widely accepted. The implication of CD40/CD40L axis in immune system disorders due to its important role as signal transduction pathway among immune cells is well documented. Several studies have suggested that CD40/CD40L interactions regulate oxidative stress; this can affect various signaling pathways leading to IBD development. Hence, CD40/CD40L signaling pathway may become a new target for IBD treatment. This review will cover the general contribution of the CD40/CD40L dyad in the development of inflammatory bowel disease, in order to facilitate future approaches aiming to elucidate the immunological mechanisms that control gut inflammation.
Krishan Maggon 's curator insight,
October 19, 2015 2:13 PM
MINI REVIEW ARTICLE Front. Immunol., 16 October 2015 | http://dx.doi.org/10.3389/fimmu.2015.00529 The contribution of CD40/CD40L axis in inflammatory bowel disease: an update
Nezha Senhaji1, Kevin Kojok2, Youssef Darif3, Christophe Fadainia2 and Younes Zaid2* 1Laboratory of Genetic and Molecular Pathology (LGPM), Medical School, Hassan II University, Casablanca, Morocco2Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, QC, Canada3Laboratory of Physiology and Molecular Genetic, Faculty of Sciences, Hassan II University, Casablanca, Morocco
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RT @britsocimm: "Eosinophils: important players in humoral immunity". Read full review: http://t.co/mpFeJUtDxq #immunology #science http://…
Gilbert C FAURE's insight:
Eosinophils perform numerous tasks. They are involved in inflammatory reactions associated with innate immune defence against parasitic infections and are also involved in pathological processes in response to allergens. Recently, however, it has become clear that eosinophils also play crucial non-inflammatory roles in the generation and maintenance of adaptive immune responses. Eosinophils, being a major source of the plasma cell survival factor APRIL (activation and proliferation-induced ligand), are essential not only for the long-term survival of plasma cells in the bone marrow, but also for the maintenance of these cells in the lamina propria which underlies the gut epithelium. At steady state under non-inflammatory conditions eosinophils are resident cells of the gastrointestinal tract, although only few are present in the major organized lymphoid tissue of the gut – the Peyer's patches (PP). Surprisingly, however, lack of eosinophils abolishes efficient class-switching of B cells to immunoglobulin (Ig)A in the germinal centres of PP. Thus, eosinophils are required to generate and to maintain mucosal IgA plasma cells, and as a consequence their absence leads to a marked reduction of IgA both in serum and in the gut-associated lymphoid tissues (GALT). Eosinophils thus have an essential part in long-term humoral immune protection, as they are crucial for the longevity of antibody-producing plasma cells in the bone marrow and, in addition, for gut immune homeostasis.
Gilbert C FAURE's curator insight,
October 19, 2015 5:18 AM
Eosinophils perform numerous tasks. They are involved in inflammatory reactions associated with innate immune defence against parasitic infections and are also involved in pathological processes in response to allergens. Recently, however, it has become clear that eosinophils also play crucial non-inflammatory roles in the generation and maintenance of adaptive immune responses. Eosinophils, being a major source of the plasma cell survival factor APRIL (activation and proliferation-induced ligand), are essential not only for the long-term survival of plasma cells in the bone marrow, but also for the maintenance of these cells in the lamina propria which underlies the gut epithelium. At steady state under non-inflammatory conditions eosinophils are resident cells of the gastrointestinal tract, although only few are present in the major organized lymphoid tissue of the gut – the Peyer's patches (PP). Surprisingly, however, lack of eosinophils abolishes efficient class-switching of B cells to immunoglobulin (Ig)A in the germinal centres of PP. Thus, eosinophils are required to generate and to maintain mucosal IgA plasma cells, and as a consequence their absence leads to a marked reduction of IgA both in serum and in the gut-associated lymphoid tissues (GALT). Eosinophils thus have an essential part in long-term humoral immune protection, as they are crucial for the longevity of antibody-producing plasma cells in the bone marrow and, in addition, for gut immune homeostasis.
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World J Clin Oncol. 2015 Oct 10;6(5):111-32. doi: 10.5306/wjco.v6.i5.111. Review
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Men who recovered from Ebola in Sierra Leone had traces of the virus in their semen for as long as nine months after they got sick, a new study found, while scientists in a separate case said they found evidence that a man in Liberia transmitted...
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ANTI-Chlamydia trachomatis SECRETORY IgA DETECTION IN A VENEZUELAN INFERTILE WOMEN POPULATION
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Researchers have been studying mucus in the lungs of cystic fibrosis patients, and their primary goal was to design inhalable therapeutic nanoparticles that cross the cystic fibrosis mucus barrier in the lung.
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