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Researchers are discovering how crucial microbes are to our health and to avoiding a range of newly common diseases. So it’s time to get dirty, eat better and stop overusing antibiotics. 
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Curious about Secretory IgA and IgG in Equine saliva? https://t.co/iB4IHNaD0V #loveelisa #westernblot #antibodies https://t.co/seNnT51XEF
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SMI Tribute Video to Per Brandtzaeg History of Mucosal Immunology by Per Brandtzaeg Historical Interview with Per Brandtzaeg
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![[Articles] Vaccine-induced mucosal immunity to poliovirus: analysis of cohorts from an open-label, randomised controlled trial in Latin American infants | Mucosal Immunity | Scoop.it](https://img.scoop.it/q3_avQ1KO_gNfHiaas75Bzl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
From BioPortfolio: Mucosal type-2-specific antibodies can be measured in stool and develop in response to receipt of OPV type 2 either in the primary vaccine series or a
Gilbert C FAURE's insight:
the link to the open access lancet paper
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Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common g-chain cytokine receptor subunit IL-2Rg or the gene encoding the tyrosine kinase JAK3. T cell reconstitution was observed in patients with SCID after hematopoietic stem cell transplantation (HSCT), but the patients still had considerably fewer ILCs in the absence of myeloablation than did healthy control subjects, with the exception of rare cases of reconstitution of the ILC1 subset of ILCs. Notably, the ILC deficiencies observed were not associated with any particular susceptibility to disease, with follow-up extending from 7 years to 39 years after HSCT. We thus report here selective ILC deficiency in humans and show that ILCs might be dispensable in natural conditions, if T cells are present and B cell function is preserved.
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RT @DrMaureenHanson: My Labroots webinar on #MECFS & the microbiome on demand at https://t.co/GNv4dK98fL. You register (free), log in, sele…
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The history and domestication of yeast used for making beer and other types of alcohol
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AAV-Mediated Colonic Secretory Expression of HMGB1 a Box Attenuates Experimental #Colitis in Mice https://t.co/RC3ws8qpGO
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EMBO J. 2016 Sep 1. pii: e201694550. [Epub ahead of print]
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Author Summary Parainfluenza viruses (PIV) are major respiratory pathogens that infect almost all children before the age of 5. Infection is particularly severe and life threatening in immunocompromised patients.
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most cats with upper respiratory tract #aspergillosis have Aspergillus-IgA antibodies that can be detected by ELISA https://t.co/Ye7evlNOJz
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Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation
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Precursor T cells bearing the same antigen receptor adopt two different fates in mice.
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The aging process leads to alterations of gut microbiota and modifications to the immune response, such changes may be associated with increased disease risk.
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Cambridge Healthtech Institute’s 2nd Annual Targeting the Microbiome is expanding from a 1.5 day conference to a 3.0 day conference. The first half of the conference will discuss the underlying mechanisms of the disease.
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Food allergies, especially in children, are becoming more and more at the center of different kinds of research: immunological, gastroenterological, geneti
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Differences in the composition of the gut microbiota of infants associate with relative risk of atopy in childhood, and metabolites linked with these distinct microbial states alter T cell differentiation ex vivo.
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Helicobacter pylori infection is associated with several gastrointestinal disorders in the human population worldwide. High-mobility group box 1 (HMGB1), a ubiquitous nuclear protein, mediates a variety of inflammation functions. The interaction between HMGB1 and receptor for advanced glycation end-products (RAGE) triggers nuclear factor (NF)-κB expression, which in turn stimulates the release of proinflammatory cytokines such as interleukin (IL)-8 and enhances the inflammatory response. However, how H. pylori activates HMGB1 expression and mobilizes RAGE into cholesterol-rich microdomains in gastric epithelial cells to promote inflammation has not been explored. In this study, we found that HMGB1 and RAGE expression increased significantly in H. pylori-infected cells compared to uninfected cells. Blocking HMGB1 by neutralizing antibody abrogated H. pylori-elicited RAGE, suggesting that RAGE expression follows HMGB1 production, and silenced RAGE-attenuated H. pylori-mediated NF-κB activation and IL-8 production. Furthermore, significantly more RAGE was present in detergent-resistant membranes extracted from H. pylori-infected cells than in those from uninfected cells, indicating that H. pylori exploited cholesterol to induce the HMGB1 signaling pathway. These results indicate that HMGB1 plays a crucial role in H. pylori-induced inflammation in gastric epithelial cells, which may be valuable in developing treatments for H. pylori-associated diseases.
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The Microbes in Health and Disease research programme at the University Medical Center Groningen (UMCG) proposes the Doctoral Training Programme PRONKJEWAIL (‘a real gem’) in the field of hospital care and infection. The specific training objective is ‘protecting patients with enhanced susceptibility to infections’. PRONKJEWAIL will recruit 16 international PhD students, who will be trained in research, transferable skills, and network and capacity building. They will be guided by experienced supervisors from the departments of Medical Microbiology, Internal Medicine, Intensive Care, Clinical Pharmacy and Pharmacology, Paediatrics, Surgery, Cell Biology, and Pharmacoepidemiology and Pharmacoeconomics at the UMCG. 26 partner organisations, including 14 private sector partners, are committed to support ESR training via mentoring, courses and secondments. Research training builds on four Pillars: 1) vaccines and primary prevention; 2) personalized detection and infection prevention; 3) iatrogenic influence on the microbiome and 4) personalized therapy/stewardship.
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Scientists at the University of British Columbia have made a discovery that could potentially lead to treatments for a debilitating complication of Crohn’s disease.
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Author Summary Trichinellosis is one of the most important food-borne parasitic zoonoses, and a serious public health issue worldwide. Developing a vaccine is an alternative approach to control the disease.
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Microbiol Immunol. 2015 Dec;59(12):716-23. doi: 10.1111/1348-0421.12336. Research Support, Non-U.S. Gov't
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