Milk-secreting cells transform into cellular eaters and start consuming each other after children get weaned.
Mucosal Immunity
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Macrophages are essential to maintaining lung homoeostasis and recent work has demonstrated that influenza-infected lung macrophages downregulate their expression of the scavenger receptor CD36.
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Kurtis F. Budden, Shaan L. Gellatly, David L. A. Wood, Matthew A. Cooper, Mark Morrison, Philip Hugenholtz & Philip M. Hansbro AffiliationsCorresponding author Nature Reviews Microbiology (2016) doi:10.1038/nrmicro.2016.142 Published online 03 October 2016
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The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently been linked to alterations in immune responses and to disease development in the lungs. In this Opinion article, we review the microbial species that are usually found in healthy gastrointestinal and respiratory tracts, their dysbiosis in disease and interactions with the gut–lung axis. Although the gut–lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.
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PeerJ. 2016 Sep 14;4:e2433. doi: 10.7717/peerj.2433. eCollection 2016.
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Despite extensive research in the area of cow fertility, the extent to which the maternal immune system is modulated during pregnancy in cattle remains unclear.
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BOSTON, Sept. 28, 2016 /PRNewswire-USNewswire/ -- Researchers reveal how dangerous intestinal toxin enters cells. Finding could lead to bette
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Protein drugs, which derive from biological sources, represent some of the most important and effective biopharmaceuticals on the market.
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To date, biologists have typically had to study the progress of a virus through indirect means, such as studying the antibodies -- actually tracking th
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Milk-derived exosomes were identified as a novel mechanism of mother-to-child transmission of regulatory molecules, but their functions in intestinal tissues of neonates are not well-studied.
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![The Lancet: [Comment] Unravelling mucosal immunity to poliovirus | Mucosal Immunity | Scoop.it](https://img.scoop.it/rYxunjRKryuKXToyGo_ZkDl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
[Comment] Unravelling mucosal immunity to poliovirus
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Nutrients. 2015 Dec 2;7(12):10020-31. doi: 10.3390/nu7125515. Research Support, Non-U.S. Gov't; Review
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The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins | The ectodomain of the human polymeric Ig receptor maintains a closed triangular shape that binds and excludes bacteria in mucosa, or opens to bind and transport polymeric Ig ligands across epithelial cells.
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Scientists have long understood that mother's milk provides immune protection against some infectious agents through the transfer of antibodies, a process referred to as "passive immunity." A research team at the Universit...
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Rac1 Controls Both the Secretory Function of the Mammary Gland and Its Remodeling for Successive Gestations https://t.co/2OBivylRao
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Nephrol Dial Transplant. 2016 Sep 28. pii: gfw343. [Epub ahead of print]
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Autoimmun Rev. 2016 Sep 21. pii: S1568-9972(16)30208-7. doi: 10.1016/j.autrev.2016.09.013. [Epub ahead of print] REVIEW
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Vaccine. 2016 Sep 23. pii: S0264-410X(16)30826-X. doi: 10.1016/j.vaccine.2016.09.013. [Epub ahead of print]
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Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.6b00598
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St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimi
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The trillions of microbes inhabiting our gut can greatly affect how we respond to infection, but scientists do not fully understand the molecular mechanisms shaping how different microbes interact with the host. Rangan et al . found that both worms and mice harboring Enterococcus faecium can better tolerate Salmonella infection. In both cases, tolerance requires E. faecium to express the enzyme secreted antigen A (SagA). SagA can also exert this probiotic effect when expressed by other bacteria. SagA protects worms by cleaving bacterial peptide fragments so that they can stimulate the tol-1 protein. In mice, Pedicord et al . found that SagA protects against Salmonella and Clostridium difficile pathogenesis in a manner dependent on antimicrobial peptides and multiple innate immune receptors.
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J Immunol. 2016 Sep 21. pii: 1502641. [Epub ahead of print]
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Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood. - PubMed - NCBI
PLoS One. 2016 Sep 19;11(9):e0162244. doi: 10.1371/journal.pone.0162244.
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Immunology and Cell Biology focuses on the general functioning of the immune system in its broadest sense, with a particular emphasis on its cell biology.
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