 Your new post is loading...
Your new post is loading...
Scoop.it!
Two body systems thought to be functionally separate have been found to be connected through gut bacteria. From Oregon State University, scientists identif 
No comment yet.
Sign up to comment
Scoop.it!
The extracellular matrix enzyme ADAMTS5 enhances the clearance of viruses by facilitating migration of T lymphocytes to the periphery following influenza virus infection.
Scoop.it!
Interferon (IFN) lambdas are critical antiviral effectors in hepatic and mucosal infections. Although IFNλ1, IFNλ2, and IFNλ3 act antiviral, genetic association studies have shown that expression of the recently discovered IFNL4 is detrimental to hepatitis C virus (HCV) infection through a yet unknown mechanism. Intriguingly, human IFNL4 harbors a genetic variant that introduces a premature stop codon. We performed a molecular and biochemical characterization of IFNλ4 to determine its role and regulation of expression. We found that IFNλ4 exhibits similar antiviral activity to IFNλ3 without negatively affecting antiviral IFN activity or cell survival. We show that humans deploy several mechanisms to limit expression of functional IFNλ4 through noncoding splice variants and nonfunctional protein isoforms. Furthermore, protein-coding IFNL4 mRNA are not loaded onto polyribosomes and lack a strong polyadenylation signal, resulting in poor translation efficiency. This study provides mechanistic evidence that humans suppress IFNλ4 expression, suggesting that immune function is dependent on other IFNL family members.
Scoop.it!
Some of our resident viruses may be beneficial.
Scoop.it!
The November issue of Trends in Immunology with a focus on #AntigenPresentation is online! With a cover by @ReitsCTH https://t.co/TnV0MDzm5G
Scoop.it!
The rising success of cancer immunotherapy has produced immense interest in defining the clinical contexts that may benefit from this therapeutic approach.
Scoop.it!
Tuberculosis (TB) is an airborne infectious disease with high morbidity and mortality rates, especially in low-income countries.
Gilbert C FAURE's insight:
after the poster, the paper
Scoop.it!
Abstract The now-famous term “restriction” derived from experiments in which T cells from Donor A failed to recognize Ags presented by cells from Donor B. Restriction results from interdonor variation in MHC genes. Donor restriction dominates immunologists’ thinking about the T cell response because it governs organ transplantation and hinders the discovery of disease-associated Ags. However, other T cells can be considered “donor unrestricted” because their targets, CD1a, CD1b, CD1c, CD1d, or MR1, are expressed in a similar form among all humans. A striking feature of donor unrestricted T cells is the expression of invariant TCRs with nearly species-wide distribution. In this article, we review new evidence that donor unrestricted T cells are common in humans. NKT cells, mucosa-associated invariant T cells, and germline-encoded mycolyl-reactive T cells operate outside of the familiar principles of the MHC system, providing a broader picture of T cell function and new opportunities for therapy.
Gilbert C FAURE's insight:
Share your insight
Scoop.it!
Immunol Rev. 2016 Nov;274(1):233-244. doi: 10.1111/imr.12467. Review
|
Scoop.it!
The research into T cell development within an organ called the thymus revealed for the first time that a protein complex called LUBAC enables 'quality control' of the cells before they are released into the bloodstream.
Scoop.it!
Cell Rep. 2016 Nov 15;17(8):2151-2160. doi: 10.1016/j.celrep.2016.10.056.
Scoop.it!
Learn and Find out the difference between both elements A and B. For more videos regarding difference between please check out our official Channel
Gilbert C FAURE's insight:
too quick but T cells are not central in innate immunity, thanks HY
Scoop.it!
Porcine dendritic cells (DCs) are relatively well characterized, but a clear-cut identification of all DC subsets combined with full transcriptional profiling was lacking, preventing an unbiased insight into the functional specializations of DC...
Scoop.it!
Inflammation. 2016 Nov 5. [Epub ahead of print] Review
Scoop.it!
Immunol Rev. 2016 Nov;274(1):9-15. doi: 10.1111/imr.12474. Review
Scoop.it!
Virus-fighting proteins in the immune system can sometimes help out their targets instead.
Scoop.it!
Polyploid macrophages develop in response to chronic inflammatory signaling from toll-like
Scoop.it!
Immunol Rev. 2016 Nov;274(1):218-232. doi: 10.1111/imr.12462. Review
Scoop.it!
This PrimeView highlights the complex nature of Mycobacterium tuberculosis infection; it can remain latent and asymptomatic in the lungs or progress to active tuberculosis disease, which requires prolonged treatment with multiple antibiotics and has high morbidity and mortality in high-burden, resource-poor settings.
Scoop.it!
J Allergy Clin Immunol. 2016 Sep 19. pii: S0091-6749(16)30965-4. doi: 10.1016/j.jaci.2016.07.040. [Epub ahead of print]
Gilbert C FAURE's insight:
A total of 51 patients were recruited (median age, 9.6 years). Thirteen of 51 had a genetic diagnosis of "atypical" SCID and 14 of 51 of CID. About half of the patients had less than 10% naive T cells, reduced/absent T-cell proliferation, and at least 1 significant clinical event/year, demonstrating their profound immunodeficiency. Nineteen patients (37%) underwent transplantation within 1 year of enrolment, and 5 of 51 patients died. Analysis of the HSCT decisions revealed the anticipated heterogeneity, favoring an ongoing prospective matched-pair analysis of patients with similar disease severity with or without transplantation. Importantly, so far neither the genetic diagnosis nor basic measurements of T-cell immunity were good predictors of disease evolution.
|
