For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark1–7. Here we examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated disease and lifespan. As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing pathologies. Deletion of Il11 or Il11ra1 protects against metabolic decline, multi-morbidity and frailty in old age. Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes. In lifespan studies, genetic deletion of Il11 extended the lives of mice of both sexes, by 24.9% on average. Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5% and of female mice by 25%. Together, these results demonstrate a role for the pro-inflammatory factor IL-11 in mammalian healthspan and lifespan. We suggest that anti-IL-11 therapy, which is currently in early-stage clinical trials for fibrotic lung disease, may provide a translational opportunity to determine the effects of IL-11 inhibition on ageing pathologies in older people. IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.
DIU Immunologie et Biotherapies is a french diploma associating french universities and immunology laboratories. It is dedicated to the involvement of immunology in new biotherapies, either molecular or cellular.
Gilbert C FAURE's insight:
We use Scoop.it as preferred curation tool to collect, select, comment informations flowing on the web in this rapidly evolving theme to keep teachers abreast of scientific knowledge and help students surf the wave... Feel free to be a follower!
Having worked on gene and cell therapies for the past 14 years, it’s been fascinating to help drive the evolution from purely viral approaches (adenoviruses, AAVs, lentiviruses) to non-viral platforms (lipid nanoparticles/liposomes, polymer nanoparticles, electroporation methods). Yet, the fundamental biology and end goal remain the same: delivering nucleic acids to the right cells, while avoiding off-target effects and excessive innate immune activation. The latter is especially tricky, as LNPs and other nanoparticles trigger various anti-viral and tissue damage pathways due to their resemblance with viruses (as depicted in this illustration).
The current momentum behind in vivo CAR-T delivery will put these viral and non-viral platforms into direct competition. Ultimately, the winners of that race won't just be determined by delivery efficiency, but by who can achieve the most precise tissue targeting with an acceptable, manageable safety profile, especially when treating patients with inflammatory and autoimmune diseases.
And, perhaps, the key principles we learn and the limitations we overcome in this space will define how we develop all other in vivo therapeutics in the future.
Abstract Since the inception of the World Health Organization (WHO) Extended Programme on Immunization in 1974, vaccines have saved the lives of approximately 150 million children, and they continue to save 2–5 million lives each year, according to WHO estimates. The consensus around the benefit and funding of childhood vaccination in low- and middle-income countries has unraveled, and the hard-won gains of the past quarter century are at risk. At the same time, in some high-income countries, vaccine hesitancy—sometimes enabled by government policy pronouncements—has led to reductions in vaccination, resulting in outbreaks of measles in countries that had eliminated this disease. Despite these setbacks, advances in vaccine platform technologies, new immunogens, and new and expanding target populations have the potential to extend the direct and indirect effects of vaccination across the life course. In this Perspective, we discuss how each of these advances could shape the future vaccine landscape. We also highlight cross-cutting issues, including those related to equity, manufacturing, funding and vaccine hesitancy, which make successful implementation more complex.
Our updated meta-analysis on hepatocellular carcinoma attributable to HBV and HCV across global, regional, and national levels.
Key message: a large share of HCC remains preventable through HBV vaccination, HBV treatment, and HCV testing and cure, but the burden and incidence attributable to these infections vary markedly by region, highlighting persistent inequities in prevention and control.
Pleasure to have worked with @maomao cao Catherine de Martel Nienke Catharina J. Alberts Feixue Wei Damien Georges
Pediatric CSU just got its first FDA-approved targeted therapy. The biologic era in A/I is moving fast.
With Dupixent now added to the CSU landscape in children, the treatment map in allergy-immunology keeps expanding across diseases, age groups, and mechanisms.
Here is a clean reference for current FDA-approved targeted therapies in U.S. allergy practice, organized by indication and age.
A few realities stand out: 1️⃣ One drug can now live in multiple disease spaces 2️⃣ Age cutoffs are not a footnote 3️⃣ “Best biologic” is usually the wrong conversation
The better question is: Which target fits this patient’s disease pattern, biomarkers, comorbidities, age, dosing preference, and access reality.
That is where the real decision-making lives.
Which targeted therapy has changed allergy practice the most in your view? | 12 comments on LinkedIn
💡 𝗧𝗮𝗸𝗲 𝗵𝗼𝗺𝗲 𝗺𝗲𝘀𝘀𝗮𝗴𝗲 • A single Fc A330C–FcR IIIa I106C disulfide creates stable, mammalian-expressed antibody docking complexes without post-expression modification. • The platform converts IgG antibodies into mixed-valency multispecifics carrying CD3, CD8, or IL-2 payloads. • Tuned hEGFR2 affinity preserved killing of high-antigen cells while reducing low-antigen activity.
🔥 𝗜𝗺𝗽𝗮𝗰𝘁 • This could simplify multispecific antibody discovery while enabling modular immune engagement, avidity tuning, and conditional cytokine delivery.
❓ 𝗢𝗽𝗲𝗻 𝗾𝘂𝗲𝘀𝘁𝗶𝗼𝗻𝘀 • Does the unpaired cysteine on the second Fc homodimer critically impact long term manufacturing stability? • Could this disulfide docking mechanism be optimized for FcγRI to exploit distinct therapeutic receptor affinities? • What maximal stoichiometric payload size can be achieved before spatial constraints compromise immune synapse formation?
𝗚𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗺𝗶𝘅𝗲𝗱-𝘃𝗮𝗹𝗲𝗻𝗰𝘆, 𝗺𝗼𝗱𝘂𝗹𝗮𝗿 𝗺𝘂𝗹𝘁𝗶𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗮𝗻𝘁𝗶𝗯𝗼𝗱𝗶𝗲𝘀 𝘂𝘀𝗶𝗻𝗴 𝗱𝗶𝘀𝘂𝗹𝗳𝗶𝗱𝗲-𝗹𝗶𝗻𝗸𝗲𝗱 𝗙𝗰–𝗙𝗰γ𝗥 𝗰𝗼𝗺𝗽𝗹𝗲𝘅𝗲𝘀 Miso Park et al. Nature Communications, May 2026 Corresponding author: John Williams
Recent advances in koala vaccination against chlamydia are providing valuable insights for human vaccine development. Koalas are the first wildlife species to receive conditional approval for a chlamydia vaccine, enabling researchers to observe real-world disease outcomes and vaccine effectiveness over time. Field studies have demonstrated reduced disease rates and mortality among vaccinated koalas, without evidence of bacterial resistance. This research highlights the potential of wildlife vaccination programs to inform human health strategies, particularly for complex pathogens, and underscores the importance of alternative models when traditional clinical trials are not feasible.
T-cell engaging therapies just took a great leap forward: a single injection of a modified self-amplifying RNA (saRNA) can mediate long-term clearance of malignant B cells, effectively bypassing the need for continuous intravenous infusions.
This new preprint originates from the collaborative research at Boston University. The study was driven by researchers Chloe (Kexin) Li and Joshua McGee, under the leadership of Dr. Wilson Wong and Dr. Mark Grinstaff.
Bispecific T cell engagers (BiTEs), such as the FDA-approved Blinatumomab, are highly effective cancer immunotherapies but are severely bottlenecked by their pharmacokinetics. With a remarkably short half-life of around 2 hours, conventional BiTEs require continuous daily intravenous infusions across multiple weeks, which drastically limits patient access and drives up healthcare costs. Further, the rapid peak of BiTEs can trigger severe adverse events like cytokine release syndrome (CRS). While utilizing mRNA to express BiTEs in vivo circumvents manufacturing hurdles, transient expression still dictates weekly dosing regimens.
To overcome this, the team engineered a 5-methylcytidine (m5C)-modified saRNA-BiTE system formulated in lipid nanoparticles (LNPs) targeting CD19. By leveraging the self-replicating nature of saRNA, the platform acts as an in situ bioreactor, achieving a durable, steady-state pharmacokinetic profile from a single systemic administration.
Key takeaways: • saRNA-BiTE induces robust, antigen-specific lysis of CD19+ target cells (Nalm6 and Raji). saRNA-BiTE maintains target cell killing for a full week post-transfection across all tested doses, whereas the efficacy of the mRNA-BiTE counterpart rapidly declines over the same period.
• Systemically administered saRNA avoids the initial burst exposure typical of standard mRNA therapies. In murine models, saRNA-encoded proteins maintained higher serum concentrations beyond day 14 compared to mRNA
• To simulate the incomplete leukemic cell depletion often seen in human patients, the team utilized a Nalm6 acute lymphoblastic leukemia (ALL) rechallenge model with 8 successive tumor injections. A single 3 µg dose of saRNA-BiTE completely eradicated malignant cells and prevented disease recurrence for 3 months. By the end of the study, mice treated with mRNA-BiTE and Blinatumomab had all relapsed.
•Ex vivo serum killing assays confirmed that mice treated with saRNA-BiTE maintained functional BiTE expression in circulation for up to 6 to 7 weeks post-administration.
This innovative research establishes saRNA as a highly robust platform for extended in situ therapeutic protein production. By translating continuous BiTE infusions into a single, off-the-shelf LNP injection, this approach mitigates manufacturing bottlenecks associated with complex recombinant proteins.
Shane Crotty (La Jolla Institute for Immunology) gives a comprehensive scientific review of immunological memory to vaccines with an emphasis on human vaccines and in humans.
This review covers the key adaptive immune components involved in vaccine-mediated protective immunity: B cells, CD8+ T cells, CD4+ T cells, and antibodies.
The video lecture will cover the same material as the written review (https://www.cell.com/immunity/fulltext/S1074-7613(26)00089-0) but is not a verbatim recitation of the review article. In the interest of flow, the video lecture will have very few citations. All citations are included in the written review; please refer to the review for references.
Video Chapters 00:00 Introduction to Immunological Memory 02:10 Introduction: Vaccine Impact on Health 05:55 Introduction: Circulating and Tissue Resident Memory Cells 06:06 Layers of Immune Protection 09:00 B-cell memory to vaccines: Introduction 09:50 B-cell memory to vaccines: Durability 35:12 B-cell memory to vaccines: Functionalities 56:00 B-cell memory to vaccines: Hybrid immunity and tissue resident memory 1:06:33 CD8 T-cell memory to vaccines: Durability 1:12:45 CD8 T-cell memory to vaccines: Functionalities 1:15:49 CD8 T-cell memory to vaccines: Durability part 2 1:17:27 CD8 T-cell memory to vaccines: Hybrid immunity and tissue resident memory 1:22:53 CD8 T-cell memory to vaccines: Summary 1:26:02 CD4 T-cell memory to vaccines: Durability 1:29:53 CD4 T-cell memory to vaccines: Functionalities 1:38:45 CD4 T-cell memory to vaccines: Hybrid immunity and tissue resident memory 1:43:15 CD4 T-cell memory to vaccines: Summary 1:44:58 Antibody memory to vaccines: Introduction 1:46:16 Antibody memory to vaccines: Durability 2:09:27 Antibody memory to vaccines: Functionalities 2:09:47 Antibody memory to vaccines: Hybrid immunity and tissue memory 2:15:04 Antibody memory to vaccines: Summary 2:16:05 Holistic understanding of immune memory to vaccines
Dans une revue publiée dans Signal Transduction and Targeted Therapy, les scientifiques du laboratoire « Biologie du Cancer et Métabolisme » (UMR 9018 CNRS/UPSaclay/Gustave Roussy, Villejuif) proposent une analyse approfondie consacrée à la voie mTOR (mammalian Target of Rapamycin), un régulateur central de la croissance cellulaire, du métabolisme et de l’homéostasie. Cette voie de signalisation intègre de nombreux signaux intracellulaires et extracellulaires, tels que la disponibilité en nutriments, les facteurs de croissance ou le stress cellulaire, afin de coordonner les processus anaboliques et cataboliques, incluant la synthèse des protéines, des lipides et des nucléotides, l’autophagie et la dégradation protéasomale. Sa dérégulation est impliquée dans de nombreuses pathologies humaines.
À l’occasion du cinquantième anniversaire de la découverte de la rapamycine, les auteurs proposent une synthèse couvrant cinq décennies de recherche sur mTOR. Cette revue retrace l’évolution historique du domaine, depuis la caractérisation initiale des effets biologiques de la rapamycine jusqu’à l’identification de sa cible moléculaire et des voies de signalisation associées. Elle met en perspective les connaissances fondamentales et récentes sur le rôle de mTOR dans la plupart des champs de la biologie cellulaire et du développement, tout en soulignant l’essor des stratégies thérapeutiques ciblant cette voie.
Une attention particulière est portée au dialogue étroit entre la signalisation mTOR et la régulation mitochondriale. Cette interaction dynamique entre deux hubs métaboliques gouverne l’adaptation cellulaire, la survie, l’équilibre énergétique et les décisions de destin cellulaire. Elle joue un rôle clé dans de nombreux contextes physiopathologiques, allant du cancer et du vieillissement aux maladies neurodégénératives et aux troubles immunitaires.
We are witnessing a massive structural shift in Chinese biotech. On May 1, 2026, China officially enforced Decree No. 818, pulling the plug on a multi-billion-dollar unapproved cell therapy market and introducing some of the tightest compliance standards our industry has seen in decades.
For years, a massive regulatory gray market allowed clinics to sell unproven stem cell injections for up to $28,000, while actual manufacturing costs hovered around $400. I've watched how this hyper-profitable, unregulated ecosystem diluted true scientific innovation.
Decree No. 818 completely dismantles this gray zone through three absolute mandates:
1. Restricting all cell therapies exclusively to top-tier Grade 3A hospitals.
2. Imposing an absolute ban on charging patients during clinical research phases.
3. Levying crippling fines up to 20 times illegal profits for non-compliance.
This is not a routine policy tweak. It is an aggressive, much-needed industry purge.
My view is that up to 80% of China's 30,000+ registered cell therapy firms will face immediate elimination. While under-qualified players are already panic-selling equipment in tech hubs like Guangzhou Nansha Medical Valley, compliant, science-backed biotech operations saw their stocks hit daily limits.
The era of selling hype is over. China’s premium longevity and biotech sectors are finally entering a mature, institutional phase.
In this new landscape, survival belongs strictly to those who prioritize clinical evidence over marketing noise.
Vaccination remains one of the most effective tools in modern poultry health management.
Many major poultry diseases can cause severe economic losses, reduced productivity, and high mortality when preventive vaccination programs are ignored or delayed.
This practical guide highlights some important poultry diseases along with commonly recommended vaccines used in poultry practice.
Healthy flocks begin with prevention. Save this guide for quick reference and share it with poultry professionals, veterinarians, students, and farm managers.
The activation of pattern recognition receptors (PRRs) orchestrates inflammation and regulates adaptive immunity. To test whether tuning inflammation through PRR stimulation enhanced the efficacy of mRNA vaccines, we combined an mRNA-based vaccine generated against the ancestral spike protein of SARS-CoV-2 with mannadjuvant, a formulation of fungal mannan and aluminum hydroxide targeting the PRR dectin-2. In mice and non-human primates, mannadjuvant increased the magnitude and durability of the response elicited by the mRNA-based vaccine, and it also led to the induction of neutralizing antibodies directed against variants of concern with a high escape capacity, overcoming antigenic imprinting. Mechanistically, prolonged type I interferon (IFN) production and potentiated interleukin-1 (IL-1) signaling locally within the draining lymph node in mice or in human cells were necessary and sufficient to exert the effect of mannadjuvant. Our data indicate that antifungal PRRs can be harnessed to create more potent and durable mRNA-based vaccines. Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by mRNA-based vaccines against SARS-CoV-2 variants in mice and non-human primates.
A new Science Immunology paper by Yuxi Wei et al. makes an important point for translational immunology and cell therapy:
What we observe ex vivo or in vitro may not fully predict what immune cells can become, or do, in vivo.
The study shows that Foxp3-transduced conventional T cells can acquire endogenous Foxp3 expression, Treg-like transcriptomic and chromatin features, and suppressive function specifically in vivo. This suggests that Foxp3 acts not only as a transcriptional regulator, but as a context-dependent driver of Treg epigenetic identity.
To me, the key message is biological context.
The in vivo environment, including reduced AKT-mTOR signaling and engagement of STAT5 and NF-κB, created permissive conditions for reprogramming that were not fully captured in vitro.
This matters for cell therapy. Phenotype alone is not enough. A cell may express the right markers, or fail to fully mature in simplified culture, but its therapeutic potential may depend on environmental cues, tissue context, and functional integration.
As we develop engineered Tregs, Foxp3-based approaches, and immune-modulating cellular therapies, we need models and assays that help distinguish appearance from function.
The question is not only: “What did we generate?”
It is: “What can this cell become, and what can it do, in the environment where it needs to function?”
Yuxi Wei et al., Science Immunology 2026 DOI: 10.1126/sciimmunol.aed2111
26 years after the first approval, the ADC has crossed a structural inflection point: 19 approved agents, 10 in the last 5 years, nearly 50 in late-stage development, and 260+ in the global pipeline.
Bispecific formats, TME-directed non-internalizing conjugates, and dual-payload architectures are converging on a single objective: Decoupling antitumor potency from antigen density (historically suggested threshold: ≥10⁴ antigens per cell) & homogeneity.
Next generation ADC architectures are directed at stroma-dense, antigen-heterogeneous, and pharmacologically shielded tumors previously considered inaccessible including pancreatic, glioblastoma and colorectal.
The Top1i payload class has been pivotal to this pharmacologic expansion: Its comparatively lower intrinsic potency enables higher DARs, broader bystander killing and validated activity in antigen-low tumors, as T-DXd demonstrated in HER2-low breast cancer.
Yet only 0.1% of administered ADC reaches tumor cells due to systemic clearance and restricted access; The remaining 99.9% drives normal tissue exposure and makes toxicity the primary clinical constraint, transforming containment of systemic payload release into the decisive engineering frontier.
So the therapeutic window is no longer solely fixed by the target but engineered through payload-linker-antibody co-optimization.
The next competitive edge belongs to platforms that integrate modularity across all 3 components with biomarker-guided patient stratification. Target-centric development in the absence of this modular foundation faces attrition by volume.
🔬 Antibody-guided vaccine design is shaping the next generation of immunization. By leveraging epitope-, nanoparticle-, and scaffold-based strategies, researchers aim to achieve more precise and durable immune protection.
Challenges remain across diverse pathogens — from influenza A and HIV to malaria, RSV, and SARS-CoV-2 — yet advances in immunogenetics and personalized vaccines may unlock stronger, more targeted antibody responses.
👉 How do you see the balance between universal and personalized vaccines evolving in the coming decade?
A clinical study shows how the intranasal FluMist vaccine can elicit potent antiflu immunity at mucosal sites, researchers tie persistent T cells in the liver to clinical cure of chronic hepatitis B, and more this week in #ScienceTranslationalMedicine.
A recent publication in Nature Medicine reports 5-year follow-up data from a phase 3 trial evaluating a single-dose live attenuated tetravalent dengue vaccine (Butantan-DV). The results show an overall efficacy of about 65% against symptomatic dengue and around 80% against severe forms, with no safety signal identified over the follow-up period .
An important aspect of dengue immunology needs to be considered when looking at longterm protection. Dengue is characterized by the coexistence of four serotypes. Infection with one serotype induces protection against that specific serotype but may increase the risk of severe disease upon subsequent infection with a different serotype. This phenomenon called antibody-dependent enhancement (ADE), is explained by the impact of non-neutralizing or subneutralizing antibodies that facilitate viral entry into host cells.
A key point is that these potentially enhancing antibodies do not appear immediately after infection or vaccination. They may emerge over time as antibody levels decline and the balance between neutralizing and non-neutralizing responses shifts. This temporal dynamic is one of the reasons why long-term follow-up is essential in dengue vaccine studies. The vaccine is designed to induce balanced immunity against all four dengue serotypes and thereby prevent the emergence of enhancing antibodies; however, this remains a theoretical goal, as neutralizing responses are not equally induced against each serotype, which may favor the development of non-neutralizing, potentially enhancing antibodies
In this study, vaccine efficacy remained significant over five years, including in individuals without prior dengue exposure, and no increase in severe dengue cases was observed in vaccinated participants . These findings are particularly relevant given previous experience with dengue vaccines, where safety concerns emerged only several years after vaccination in seronegative individuals.
Overall, these results support the importance of sustained efficacy and long-term safety assessment when evaluating dengue vaccines, in a context where immune responses can evolve over time and influence disease risk upon subsequent exposure.
The interim futility analysis for cema-cel, just gave the lymphoma field something to think about. A 41.6% absolute difference in MRD negativity at Day 45 versus observation, with clean tolerability, availability in community hospitals and most patients managed as outpatients. It is a meaningful signal that allogeneic CAR-T can work in first-line consolidation post R-CHOP.
What about the patients who relapse after cema-cel? Go back to CD19 with an autologous product: Yescarta, Breyanzi? They all target the same CD19 as cema-cel. Would a second CD19 CAR-T be reimbursed? If cema-cel moves towards commercialization in LBCL, patients who relapse will need a subsequent differentiated option. The commercial case for CD19-targeted autologous therapies in this setting will need rethinking.
This is where eti-cel becomes relevant. A highly differentiated product also developed at Cellectis, on the same backbone as cema-cel (originated from Cellectis platform), eti-cel targets both CD20×CD22 simultaneously. Data at the current dose show 88% ORR and 63% CR in heavily pretreated patients, a strong signal for a dual allogeneic approach.
Fifteen years ago, CAR-T emerged as a revolution. The real breakthrough, the bona fide pharmaceutical product, is allogeneic. Off-the-shelf, scalable, standardized. It will establish a new order in cell therapy. Autologous therapies are a process and will, in time, disappear.
On in vivo CAR-T: the science is early, the toxicity profile remains unfavorable today, and the regulatory path for a therapy where the vector is the product is, at best, unclear.
Cellectis Allogene Therapeutics Kite Pharma Bristol Myers Squibb Novartis Johnson & Johnson Gilead Sciences #dlcl #CART #celltherapy #allogeneic | 14 comments on LinkedIn
VACCINES are most effective in harnessing the immune system to produce high levels of antibodies to stable and accessible targets. BUT, malaria parasites, HIV, and the influenza virus are capable of hiding their weakest parts from the immune system.
WHAT IF the immune system could be PROGRAMMED to produce high levels of those rare antibodies capable of finding and neutralizing the most vulnerable pathogenic features of these parasites? In this weeks issue of Science, Hartweger et al. (2026, Science 392, eadz8994) reported findings using a mouse model, in which they demonstrated that the self-amplification properties of the immune system could be harnessed to produce high levels of these rare neutralizing therapeutic antibodies. They used hematopoietic stem and precursor cells (HSPCs) to give rise to B lymphocytes activated to produce high titers of long-lasting neutralizing antibodies in mice that protected them from a lethal influenza infection.
Here is a news article highlighting this seminal research, and the avenues it has opened for future therapies for human diseases and infections:
A malaria vaccine showing up to 90% protection in early clinical studies and a key question: how does it work? That’s what the European CAPTIVATE consortium is working on. BPRC is a partner.
In Antwerp, researchers from across Europe came together to share progress and align next steps.
The CAPTIVATE consortium approach is fundamentally different. Instead of using fragments of the parasite, this vaccine uses a genetically attenuated version of the malaria parasite itself.
After vaccination, the parasite reaches the liver, but stops there. It cannot develop further. This allows the immune system to recognise and eliminate the parasite at the earliest stage, before it causes disease.
“The strong protection seen in healthy volunteers often doesn’t translate to endemic settings”, says Erica Pasini (BPRC). “We want to understand why and how to make it work where it matters most.”
At BPRC, we contribute by studying immune responses in greater depth, helping to bridge the gap between controlled studies and real-world impact. During the meeting, scientists shared the latest developments. Key project milestones have already been reached, and the work is in full swing!
Next step: in June, the first results of the non-human primate trial will become available along with key samples to further investigate the immune mechanisms behind protection.
Dans une revue publiée dans Trends in Biochemical Sciences, Xia Xiao et Svetlana Dokudovskaya de l’UMR 9018 METSY (CNRS/UPSaclay/Gustave Roussy, Villejuif) font le point sur cinquante années de recherche autour de la rapamycine, une molécule initialement décrite comme antifongique et devenue un pilier de la biologie moderne. Cet article, un Feature Review, a été sélectionné pour être mis à l’honneur en couverture et s’inscrit dans la série spéciale « TIBS at 50: Foundations and Frontiers ».
Les auteurs retracent l’histoire de la découverte de la rapamycine à partir d’échantillons de sol de l’île de Pâques (Rapa Nui), et montrent comment l’étude de cette molécule a conduit à l’identification d’une voie de signalisation majeure, la voie TOR (Target of Rapamycin). Contrairement à d’autres molécules emblématiques comme la pénicilline ou la ciclosporine, la rapamycine n’a pas seulement révolutionné des applications thérapeutiques, mais a révélé un réseau biologique entièrement nouveau.
La revue met en lumière le rôle central de la voie TOR dans la régulation de la croissance cellulaire, du métabolisme, du vieillissement et de nombreuses pathologies. Elle souligne également comment cette découverte a permis d’intégrer des domaines auparavant distincts, tels que le métabolisme et la signalisation cellulaire, en introduisant le concept de détection des nutriments comme mécanisme clé de régulation.
Enfin, les auteurs discutent des perspectives actuelles et futures, illustrant l’impact durable de cette découverte, qui continue de structurer un champ de recherche en constante évolution.
To get content containing either thought or leadership enter:
To get content containing both thought and leadership enter:
To get content containing the expression thought leadership enter:
You can enter several keywords and you can refine them whenever you want. Our suggestion engine uses more signals but entering a few keywords here will rapidly give you great content to curate.
Your new post is loading...
