Immune-Monitoring
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Immune-Monitoring
Identifying antigen-specific immune cells in infection, neoplasia and auto-immunity
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Immune Correlates of Protection in Human Invasive Aspergillosis

Immune Correlates of Protection in Human Invasive Aspergillosis | Immune-Monitoring | Scoop.it

We review the most important genetic, immunological, and pharmacological factors that influence human susceptibility to Aspergillus and discuss the potential role of immune biomarkers in risk stratification strategies that facilitate individualized antifungal therapy/prophylaxis in immunocompromised hosts.

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Potential Role for HIV-Specific CD38−/HLA-DR+ CD8+ T Cells in Viral Suppression and Cytotoxicity in HIV Controllers

Potential Role for HIV-Specific CD38−/HLA-DR+ CD8+ T Cells in Viral Suppression and Cytotoxicity in HIV Controllers | Immune-Monitoring | Scoop.it
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Signatures of Protective Memory Immune Responses During HCV Reinfection

Protection from persistent HCV reinfection depends on the magnitude, breadth, and quality of the HCV-specific memory T-cell response. Sequence homology among viruses, and ability of T cells to recognize multiple strains of HCV, are critical determinants of protective memory.

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Journal of Investigative Dermatology - Propionibacterium acnes promotes Th17 and Th17/Th1 responses in acne patients

P. acnes can promote mixed Th17/Th1 responses by inducing the concomitant secretion of IL-17 A and IFNγ from specific CD4(+) T cells in vitro. We show that both P. acnes-specific Th17 and Th17/Th1 cells can be found in the peripheral blood of patients suffering from acne and, at lower frequencies, in healthy individuals.

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Cancer Vaccines : Pharmaceuticals : UK

Cancer Vaccines : Pharmaceuticals : UK | Immune-Monitoring | Scoop.it
SMi are hosting the 3rd Annual Cancer Vaccines Conference, 15th-16th Septmeber 2014, London, UK
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Association between tuberculosis recurrence and interferon-γ response during treatment

Association between tuberculosis recurrence and interferon-γ response during treatment | Immune-Monitoring | Scoop.it
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JCI - Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition

JCI - Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition | Immune-Monitoring | Scoop.it
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Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-me

Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-me | Immune-Monitoring | Scoop.it

The present data support B7-1 alone as an important costimulatory molecule in the context of LPS-mediated inflammation in atherosclerotic lesions. Due to its marked inhibitory effects, RhuDex® may be a useful therapy to modulate the inflammatory milieu in atherosclerosis.

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Sequenta’s LymphoSIGHT Platform Reveals T Cell Repertoire Changes That Predict Outcome in Patients Treated with Anti-CTLA-4 Antibody Therapies

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Vitamin D Deficiency in a Multiethnic Healthy Control Cohort and Altered Immune Response in Vitamin D Deficient European-American Healthy Controls

Vitamin D Deficiency in a Multiethnic Healthy Control Cohort and Altered Immune Response in Vitamin D Deficient European-American Healthy Controls | Immune-Monitoring | Scoop.it

A large portion of healthy individuals have vitamin D deficiency. These individuals have altered T and B cell responses, indicating that the absence of sufficient vitamin D levels could result in undesirable cellular and molecular alterations ultimately contributing to immune dysregulation.

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Pregnancy Differentially Impacts Performance of Latent Tuberculosis Diagnostics in a High-Burden Setting

Pregnancy Differentially Impacts Performance of Latent Tuberculosis Diagnostics in a High-Burden Setting | Immune-Monitoring | Scoop.it
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Defining the boundaries of a healthy immune response: functional analysis of immune responsiveness using standardized whole blood stimulation systems | Milieu Intérieur

Defining the boundaries of a healthy immune response: functional analysis of immune responsiveness using standardized whole blood stimulation systems | Milieu Intérieur | Immune-Monitoring | Scoop.it
 
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Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation

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Frontiers | Monitoring of Pathogen-Specific T-Cell Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

In this article, we aim to give a comprehensive overview regarding current developments of T-cell monitoring techniques focusing on T cells against viruses and fungi. In particular, we will focus on rather simple, fast, non-labor-intensive, cellular assays which could be integrated in routine clinical screening approaches.

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Modulation of polyfunctional hiv-specific CD8 T cells in patients responding differently to antiretroviral therapy. PubMed link

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T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

This study supports the concept that poor human viral-specific CD8+ T cell functionality is due to an inverse expression balance between T-bet and Eomes, which is not reversed despite long-term viral control through ART. These results aid to explain the inability of HIV-specific CD8+ T cells to control the viral replication post-ART cessation.

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CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination

CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination | Immune-Monitoring | Scoop.it
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Speeding Up Antiviral T Cell Production.

Speeding Up Antiviral T Cell Production. | Immune-Monitoring | Scoop.it
Scientists come up with a simpler, more efficient strategy for making multivirus-targeting T cells for immunotherapy.
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Immunovaccine Reports Promising Clinical Activity for Novel T Cell
Activating Immunotherapy DPX-Survivac at ASCO 2014

Immunovaccine Reports Promising Clinical Activity for Novel T Cell<br/>Activating Immunotherapy DPX-Survivac at ASCO 2014 | Immune-Monitoring | Scoop.it
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Immune-monitoring in Kawasaki disease patients treated with infliximab and intravenous immunoglobulin. | Global Medical Discovery

Immune-monitoring in Kawasaki disease patients treated with infliximab and intravenous immunoglobulin. | Global Medical Discovery | Immune-Monitoring | Scoop.it
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GEN | News Highlights:Single Cell Type May Open the Door to Effective Cancer Vaccines

GEN | News Highlights:Single Cell Type May Open the Door to Effective Cancer Vaccines | Immune-Monitoring | Scoop.it
Scientists at Thomas Jefferson University say they have discovered that the T helper cell is actively suppressed in several experimental cancer vaccines.
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Cancer Biology: Telomerase Peptide Vaccine Tested in Pancreatic Cancer Patients

Cancer Biology: Telomerase Peptide Vaccine Tested in Pancreatic Cancer Patients | Immune-Monitoring | Scoop.it
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Deploying the Body's Army | The Scientist Magazine®

Deploying the Body's Army | The Scientist Magazine® | Immune-Monitoring | Scoop.it
Using patients’ own immune systems to fight cancer
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Early predictive value of multifunctional skin-infiltrating lymphocytes in anticancer immunotherapy

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A T cell gene expression panel for the diagnosis and monitoring of disease activity in patients with systemic lupus erythematosus

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