 Your new post is loading...
Your new post is loading...
Scoop.it!
The genes that increase the risk of Type 1 diabetes have lost their hiding place, scientists report. A research group has located and narrowed down the number of genes that play a role in the disease, according to their study. 
No comment yet.
Sign up to comment
Scoop.it!
Amanda Warne’s periods stopped at the age of 21. For the next four years she suffered terrifying mood swings and depression.
Scoop.it!
RT @ramos_casals: Diagnosis and risk stratification in patients with anti-RNP autoimmunity http://t.co/TwBayhNW10
Scoop.it!
by Camille Luyet, Katja Schulze, Beyza S. Sayar, Denise Howald, Eliane J. Müller, Arnaud Galichet
Scoop.it!
Antibodies defend the body against bacterial, viral, and other invaders. But sometimes the body makes antibodies that attack healthy cells. In these cases, autoimmune disorders develop. Immune abn...
Gilbert C FAURE's insight:
NMDAR
Scoop.it!
From
www
UAB is testing a tablet-based decision aid in hopes of improving outcomes for minority women with lupus and kidney disease Jasvinder SinghResearchers...
Scoop.it!
Antibodies defend the body against bacterial, viral, and other invaders. But sometimes the body makes antibodies that attack healthy cells. In these cases, autoimmune disorders develop.
Scoop.it!
by Aristea Papageorgiou, Dimitrios C. Ziogas, Clio P. Mavragani, Elias Zintzaras, Athanasios G. Tzioufas, Haralampos M.
Scoop.it!
Diabetes In Control is a free weekly diabetes newsletter dedicated to helping medical professionals in diabetes care better help their diabetes patients.
Scoop.it!
Measuring autoantibodies in the blood may indicate whether the immune system has begun to attack its own insulin cells.
Gilbert C FAURE's insight:
The new findings from the NIH-funded study, which were recently published in Diabetologia, suggest three ways of predicting development of type 1 diabetes. If the autoantibody first discovered attacks insulin (IAA). In the study as a whole, this occurred by age 1 year. Dr. Lernmark noted in the release that if a second autoantibody is detected, the person may develop diabetes but perhaps not for 20 years.If the first autoantibody targets GAD65 (GADA), a protein inside the insulin-producing cells. This was most common at age 2 years in the study.If both autoantibodies are first found together. According to Dr. Lernmark, 40% of these children in the TEDDY study had already developed diabetes.In the study, participants were enrolled as infants and underwent quarterly standardized autoantibody assessments for the first 4 years of life and semi-annually thereafter.
Scoop.it!
In mice that fail to express the phagolysosomal endonuclease DNase II and the type I IFN receptor, excessive accrual of undegraded DNA results in a STING-dependent, TLR-independent inflammatory arthritis.
Scoop.it!
An MRI-based imaging technique may reveal inflammation that will give more insight into diabetes risk and treatment strategies.
Gilbert C FAURE's insight:
imaging vs autoantibodies
|
Scoop.it!
Autoantibody response against NALP5/MATER in primary ovarian insufficiency - interesting new study inn JCEM http://t.co/fW3hTCEW11
Scoop.it!
High Diversity in the TCR Repertoire of GAD65 Autoantigen-Specific
|
|
Scooped by
Gilbert C FAURE
March 8, 2015 9:36 AM
|
Scoop.it!
Here researchers discovered gene alterations characteristic of autoimmune diseases, such as inflammatory bowel disease or rheumatoid arthritis, are found in genome regions called superenhancers.
|
Suggested by
Société Francaise d'Immunologie
March 7, 2015 3:52 PM
|
Scoop.it!
Endosomal TLRs play an important role in systemic autoimmune diseases, such as systemic erythematosus lupus, in which DNA- and RNA-associated autoantigens activate autoreactive B cells through TLR9- and TLR7-dependent pathways.
|
|
Scooped by
Gilbert C FAURE
March 6, 2015 1:59 PM
|
Scoop.it!
Shire plc has submitted a New Drug Application to the FDA for its investigational compound designed to treat patients with dry eye disease.
|
|
Scooped by
Gilbert C FAURE
March 6, 2015 1:53 PM
|
Scoop.it!
“@PharmTechGroup: #Baxter builds #immunology portfolio with $225 million acquisition. http://t.co/y1I3h8XWoO”@MedsearchR @medsearch_sa
|
|
Scooped by
Gilbert C FAURE
March 6, 2015 4:48 AM
|
Scoop.it!
Although the identification of B cell subsets with negative regulatory functions and the definition of their mechanisms of action are recent events, the important negative regulatory roles of B cells in immune responses are now broadly recognized. There is an emerging appreciation for the pivotal role played by B cells in several areas of human diseases including autoimmune diseases and non-autoimmune diseases such as parasite infections and cancer. The recent research advancement of regulatory B cells in human disease coincides with the vastly accelerated pace of research on the bridging of innate and adaptive immune system. Current study and our continued research may provide better understanding of the mechanisms that promote regulatory B10 cell function to counteract exaggerated immune activation in autoimmune as well as non-autoimmune conditions. This review is focused on the current knowledge of BREG functions studied in animal models of autoimmune and non-autoimmune diseases.
|
|
Scooped by
Gilbert C FAURE
March 4, 2015 2:01 PM
|
Scoop.it!
The induction of central tolerance in the course of T cell development crucially depends on promiscuous gene expression (pGE) in medullary thymic epithelial cells (mTECs). mTECs express a genome-wi...
|
|
Scooped by
Gilbert C FAURE
March 1, 2015 2:39 PM
|
Scoop.it!
#Autoantibody #Screening: New application note about the #Autoimmune #Epitope #Microarray 2.0 http://t.co/LKrdQdBgoC http://t.co/57ZLgcGYi5
|
|
Rescooped by
Gilbert C FAURE
from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
February 24, 2015 2:24 PM
|
Scoop.it!
Sociodemographic and geographic predictors of quality of care in US patients with end-stage lupus nephritis http://t.co/88kP2WttYr
Abstract
Objective. To describe end-stage renal disease (ESRD) quality of care (receipt of pre-ESRD nephrology care, access to kidney transplantation, and permanent vascular access placement for dialysis) in U.S. patients with ESRD due to lupus nephritis (LN-ESRD) and examine whether quality measures differed by patient sociodemographics or U.S. region.
Methods. In 6,594 U.S. patients initiating treatment for LN-ESRD (7/05-9/11), we estimated odds ratios (ORs) and hazard ratios (HRs) of each quality measure with sociodemographics and U.S. region using national surveillance data.
Results. Overall, 71% received nephrology care prior to ESRD. Blacks and Hispanics were less likely than whites to receive pre-ESRD care (OR=0.73, 95% CI 0.63-0.85 and OR=0.72, 95% CI 0.60-0.88) and to be placed on the kidney transplant waitlist (HR=0.78, 95% CI 0.68-0.81 and HR=0.82, 95% CI 0.68-0.98). Those with Medicaid (HR=0.51, 95% CI 0.44-0.58) or no insurance (HR=0.36, 95% CI 0.29-0.44) were less likely than those with private insurance to be placed on the waitlist. Only 24% had a permanent vascular access, and placement was even less likely among the uninsured (OR=0.62, 95% CI 0.49-0.79). ESRD quality-of-care measures varied 2- to 3-fold across regions, with patients in the Northeast and Northwest generally having higher probabilities of adequate care.
Further studies are warranted to examine multi-level barriers to—and develop targeted interventions to improve delivery of—care among LN-ESRD patients.
DOI: 10.1002/art.38983
Copyright © 2014 American College of Rheumatology
Issue
Arthritis & RheumatologyAccepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)
|
|
Scooped by
Gilbert C FAURE
February 23, 2015 3:30 PM
|
Scoop.it!
Discovery of Native Autoantigens via Antigen Surrogate
Technology: Application to Type 1 Diabetes http://t.co/BckOv5BOeP
