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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
February 22, 2015 3:55 AM
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A Novel Mathematical Model Describing Adaptive Cellular Drug Metabolism and Toxicity in the Chemoimmune System

A Novel Mathematical Model Describing Adaptive Cellular Drug Metabolism and Toxicity in the Chemoimmune System | AUTOIMMUNITY | Scoop.it
by Attila Tóth, Anna Brózik, Gergely Szakács, Balázs Sarkadi, Tamás Hegedüs
Cells cope with the threat of xenobiotic stress by activating a complex molecular network that recognizes and eliminates chemically diverse toxic compounds.
Gilbert C FAURE's insight:

Cells cope with the threat of xenobiotic stress by activating a complex molecular network that recognizes and eliminates chemically diverse toxic compounds. This “chemoimmune system” consists of cellular Phase I and Phase II metabolic enzymes, Phase 0 and Phase III ATP Binding Cassette (ABC) membrane transporters, and nuclear receptors regulating these components.

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Scooped by Gilbert C FAURE
February 21, 2015 1:37 PM
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NIH researchers reveal link between powerful gene regulatory elements and ... - National Institutes of Health (press release)

NIH researchers reveal link between powerful gene regulatory elements and ... - National Institutes of Health (press release) | AUTOIMMUNITY | Scoop.it
Findings point to potential drug targets
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Scooped by Gilbert C FAURE
February 20, 2015 2:31 PM
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Frontiers | DFS70/LEDGFp75: an enigmatic autoantigen at the interface between autoimmunity, AIDS, and cancer | B Cell Biology

Clinical and diagnostic laboratories often encounter patient sera containing antinuclear antibodies (ANAs) that produce a nuclear dense fine speckled immunofluorescence pattern on HEp-2 cells. The...
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Scooped by Gilbert C FAURE
February 20, 2015 2:00 PM
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'Most comprehensive map' of human epigenomes is unveiled

'Most comprehensive map' of human epigenomes is unveiled | AUTOIMMUNITY | Scoop.it
Two dozen scientific papers published online simultaneously on Feb. 18, 2015 present the first comprehensive maps and analyses of the epigenomes of a wide array of human cell and tissue types.
Gilbert C FAURE's insight:

autoimmunity at the end

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Scooped by Gilbert C FAURE
February 19, 2015 1:43 PM
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Lupus Research Institute announces this year's Novel Research Grants

Lupus Research Institute announces this year's Novel Research Grants | AUTOIMMUNITY | Scoop.it
As the Lupus Research Institute celebrates its 15th anniversary, the engine of innovation moves forward at accelerated speed with the announcement of this year's Novel Research Grants bringing new talent from a wide diversity of specialties.
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Scooped by Gilbert C FAURE
February 18, 2015 1:33 PM
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Quebec City insurer SSQ first to develop autoimmune coverage

Quebec City insurer SSQ first to develop autoimmune coverage | AUTOIMMUNITY | Scoop.it
SSQ Financial Group Inc. is set to become the first Canadian insurer to address some of the chronic conditions that turn the body’s immune system against itself
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Suggested by Société Francaise d'Immunologie
February 17, 2015 3:59 PM
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Distinguishing the cerebrospinal fluid cytokine profile in neuropsy... - PubMed - NCBI

Clin Immunol. 2015 Feb 2. pii: S1521-6616(15)00029-7. doi: 10.1016/j.clim.2015.01.010. [Epub ahead of print]
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Scooped by Gilbert C FAURE
February 16, 2015 1:52 PM
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B-Cell Antibody Modestly Improves Sjogren?s Symptoms - MedPage Today

B-Cell Antibody Modestly Improves Sjogren?s Symptoms - MedPage Today | AUTOIMMUNITY | Scoop.it
Study says further randomized, controlled trials needed to gauge effectiveness.
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Scooped by Gilbert C FAURE
February 16, 2015 1:25 PM
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What is LADA? - Potential Insights from Ongoing Genetic Evaluations - Diabetes In Control

What is LADA? - Potential Insights from Ongoing Genetic Evaluations - Diabetes In Control | AUTOIMMUNITY | Scoop.it
Diabetes In Control is a free weekly diabetes newsletter dedicated to helping medical professionals in diabetes care better help their diabetes patients.
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Scooped by Gilbert C FAURE
February 16, 2015 1:23 PM
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Gut Virome Sequencing in Children With Early Islet Autoimmunity.

Gut Virome Sequencing in Children With Early Islet Autoimmunity. | AUTOIMMUNITY | Scoop.it
Authors: Lenka Kramná, Kateřina Kolářová, Sami Oikarinen, Juha-Pekka Pursiheimo, Jorma Ilonen, Olli Simell, Mikael Knip, Riitta Veijola, Heikki Hyöty, Ondrej Cinek, Discipline: Medicine, Type: Journal Article...
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Scooped by Gilbert C FAURE
February 16, 2015 1:20 PM
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Latent Autoimmune Diabetes in Adult: Current Knowledge - HCPLive

Latent Autoimmune Diabetes in Adult: Current Knowledge - HCPLive | AUTOIMMUNITY | Scoop.it
In recent years, growing understanding of diabetes has led to its recognition as a multifaceted disease that cannot simply be dichotomized into its 2 most common subgroups.
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Scooped by Gilbert C FAURE
February 16, 2015 1:19 PM
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Discovery and horizontal follow-up of an autoantibody signature in ... - PubMed - NCBI

Proc Natl Acad Sci U S A. 2015 Feb 9. pii: 201500097. [Epub ahead of print]
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Scooped by Gilbert C FAURE
February 16, 2015 1:19 PM
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Arthritis Research & Therapy | Full text | T-cell metabolism in autoimmune disease

Cancer cells have long been known to fuel their pathogenic growth habits by sustaining a high glycolytic flux, first described almost 90 years ago as the so-called Warburg effect.
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Scooped by Gilbert C FAURE
February 22, 2015 3:54 AM
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Novel Receptor-Derived Cyclopeptides to Treat Heart Failure Caused by Anti-β1-Adrenoceptor Antibodies in a Human-Analogous Rat Model

Novel Receptor-Derived Cyclopeptides to Treat Heart Failure Caused by Anti-β1-Adrenoceptor Antibodies in a Human-Analogous Rat Model | AUTOIMMUNITY | Scoop.it
by Valérie Boivin, Niklas Beyersdorf, Dieter Palm, Viacheslav O. Nikolaev, Angela Schlipp, Justus Müller, Doris Schmidt, Vladimir Kocoski, Thomas Kerkau, Thomas Hünig, Georg Ertl, Martin J.
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Scooped by Gilbert C FAURE
February 20, 2015 2:57 PM
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Angiotensin II type 1 receptor autoantibody as a novel regul... : Journal of Hypertension

Background: Preeclamptic women and their infants have significant morbidity and mortality worldwide.
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Scooped by Gilbert C FAURE
February 20, 2015 2:30 PM
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Suppression of systemic autoimmunity by the innate immune adaptor STING

Suppression of Systemic Autoimmunity by the Innate Immune Adaptor STING @PittTweet http://t.co/EKAb0d6d21
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Scooped by Gilbert C FAURE
February 20, 2015 2:32 AM
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Researchers wind up a 40 year old debate on betaretrovirus infection in humans

Researchers wind up a 40 year old debate on betaretrovirus infection in humans | AUTOIMMUNITY | Scoop.it
New light has been shed on primary biliary cirrhosis, a rare liver disease that affects up to one in 500 middle aged women.
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Scooped by Gilbert C FAURE
February 18, 2015 1:37 PM
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Autoimmunity, not a developmental defect, is the cause for subferti... - PubMed - NCBI

Scand J Immunol. 2015 Feb 17. doi: 10.1111/sji.12280. [Epub ahead of print]
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Scooped by Gilbert C FAURE
February 17, 2015 4:07 PM
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Link between powerful gene regulatory elements and autoimmune diseases

Link between powerful gene regulatory elements and autoimmune diseases | AUTOIMMUNITY | Scoop.it
Investigators have discovered the genomic switches of a blood cell key to regulating the human immune system.
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Scooped by Gilbert C FAURE
February 17, 2015 10:31 AM
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Significance of Myositis-Specific and Myositis-Associated Autoantibodies: Myositis-specific Autoantibodies

Myositis-specific Autoantibodies: Myositis-specific or -associated autoantibodies are closely linked to characteristic clinical manifestations of idiopathic inflammatory myopathy and may facilitate diagnosis, prognosis, and treatment choice.
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Scooped by Gilbert C FAURE
February 16, 2015 1:26 PM
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FOXP3 autoantibody as a potential early prognostic serum biomarker ... - PubMed - NCBI

Int J Clin Oncol. 2015 Feb 15. [Epub ahead of print]
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Scooped by Gilbert C FAURE
February 16, 2015 1:24 PM
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Rheumatology & Autoimmunity Congress - Timetable

Rheumatology & Autoimmunity Congress - Timetable | AUTOIMMUNITY | Scoop.it
Early bird registration for 2 more days- International controversies in rheumatology and autoimmunity (CORA) http://t.co/9acUeyh576
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Scooped by Gilbert C FAURE
February 16, 2015 1:21 PM
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Discovery and horizontal follow-up of an autoantibody signature in human prostate cancer

An autoantibody marker to detect aggressive prostate #cancer? http://t.co/f3WQ9N9qjQ @PNASNews #indivmed http://t.co/KbSyKMcnDt
Gilbert C FAURE's insight:

In this report, serum antibodies to alpha-2–Heremans–Schmidt glycoprotein (fetuin-A) were demonstrated to display increased reactivity with concomitant development of metastatic castrate-resistant disease in a large cohort of prostate cancer patients.

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Scooped by Gilbert C FAURE
February 16, 2015 1:19 PM
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MHC associations with clinical and autoantibody manifestations in E... - PubMed - NCBI

Genes Immun. 2014 Apr;15(4):210-7. doi: 10.1038/gene.2014.6. Epub 2014 Mar 6. Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Scooped by Gilbert C FAURE
February 16, 2015 1:19 PM
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New insights into the role of mast cells in autoimmunity: Evidence for a common mechanism of action?

New insights into the role of #mast #cells in #autoimmunity: Evidence for a common mechanism of action? - http://t.co/9dR0MoywCP #MCAS
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