AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
March 22, 2015 5:20 AM
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A new approach for diagnosing type 1 diabetes in autoantibody-posit... - PubMed - NCBI

Diabetes Care. 2015 Feb;38(2):271-6. doi: 10.2337/dc14-1813. Epub 2014 Dec 17. Research Support, N.I.H., Extramural
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Scooped by Gilbert C FAURE
March 20, 2015 9:24 PM
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Frontiers | DFS70/LEDGFp75: An Enigmatic Autoantigen at the Interface between Autoimmunity, AIDS, and Cancer | B Cell Biology

Clinical and diagnostic laboratories often encounter patient sera containing antinuclear antibodies (ANAs) that produce a nuclear dense fine speckled immunofluorescence pattern on HEp-2 cells. The...
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Scooped by Gilbert C FAURE
March 20, 2015 12:16 PM
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Happy to tell you our Autoimmunity Highlights is now published #OA and is accepting submissions. Check it out! http://t.co/vrnFjlIhst
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Scooped by Gilbert C FAURE
March 20, 2015 12:09 PM
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High mobility group box 1 contributes to anti-neutrophil cytoplasmic antibody-induced neutrophils activation through receptor for advanced glycation end products (RAGE) and Toll-like receptor 4

High mobility group box 1 contributes to anti-neutrophil cytoplasmic antibody-induced neutrophils activation through receptor for advanced glycation end products (RAGE) and Toll-like receptor 4 - up-to-the-minute news and headlines.
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Scooped by Gilbert C FAURE
March 17, 2015 12:29 PM
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Mesenchymal Stem/Stromal Cells Protect against Autoimmunity via CCL... - PubMed - NCBI

J Immunol. 2015 Mar 13. pii: 1402139. [Epub ahead of print]
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Scooped by Gilbert C FAURE
March 14, 2015 10:46 AM
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Circulating Autoantibodies against the Apolipoprotein B-100 Peptides p45 and p210 in Relation to the Occurrence of Carotid Plaques in 64-Year-Old Women

Circulating Autoantibodies against the Apolipoprotein B-100 Peptides p45 and p210 in Relation to the Occurrence of Carotid Plaques in 64-Year-Old Women | AUTOIMMUNITY | Scoop.it
by Björn Fagerberg, Ulrica Prahl Gullberg, Ragnar Alm, Jan Nilsson, Gunilla Nordin Fredrikson
Objectives Immune responses against oxidized low density lipoprotein (LDL) play a key role in atherosclerosis.
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Scooped by Gilbert C FAURE
March 14, 2015 10:45 AM
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Autoimmune Process Plays Major Role in Triggering Narcolepsy - Sleep Review

Autoimmune Process Plays Major Role in Triggering Narcolepsy - Sleep Review | AUTOIMMUNITY | Scoop.it
A new study published by Yehuda Shoenfeld finds that narcolepsy bears the trademarks of a classic autoimmune disorder.
Gilbert C FAURE's insight:

81st immune disease

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Scooped by Gilbert C FAURE
March 14, 2015 10:22 AM
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New antibody therapy dramatically improves psoriasis symptoms in clinical trial

New antibody therapy dramatically improves psoriasis symptoms in clinical trial | AUTOIMMUNITY | Scoop.it
Many patients suffering from psoriasis showed significant recovery after just a single dose of an experimental treatment with a human antibody that blocks an immune signaling protein crucial to the disease, researchers report.
Gilbert C FAURE's insight:

IL-23 in JACI

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Scooped by Gilbert C FAURE
March 12, 2015 3:44 PM
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Frontiers | The uses and misuses of multiplex autoantibody assays in systemic autoimmune rheumatic diseases | B Cell Biology

Autoantibodies to cellular constituents are the serological hallmark in systemic autoimmune rheumatic diseases 1. They are often associated with certain diagnosis, clinical features, or disease act...
Gilbert C FAURE's insight:

Multiplex immunoassays for autoantibodies differ significantly depending on the manufacturer or kits and do not always show the intended specificity and sensitivity. These assays should be validated against a standard assay before releasing to the market or using in research to avoid confusions among clinicians and researchers. Postmarket evaluation of these technologies including systematic evaluation and standardization of assays are warranted.

 nice synthesis

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Scooped by Gilbert C FAURE
March 12, 2015 3:43 PM
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University Technology > Life Sciences > Next generation Factor H diagnostics

University Technology > Life Sciences > Next generation Factor H diagnostics | AUTOIMMUNITY | Scoop.it
A polypeptide (TCP) that can be used to develop more sensitive and selective diagnostics for detecting Factor H and Factor H autoantibodies.University Technology provides easy and straight forward access to Scotland’s rich portfolio of leading...
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Scooped by Gilbert C FAURE
March 11, 2015 2:56 PM
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Solving the puzzle of autoimmunity: critical questions. - PubMed - NCBI

F1000Prime Rep. 2015 Feb 3;7:17. doi: 10.12703/P7-17. eCollection 2015. Review
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Suggested by Société Francaise d'Immunologie
March 11, 2015 2:49 PM
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A Comparative Analysis of Multiple Sclerosis-Relevant Anti-Inflammatory Properties of Ethyl Pyruvate and Dimethyl Fumarate [AUTOIMMUNITY]

Dimethyl fumarate (DMF), a new drug for multiple sclerosis (MS) treatment, acts against neuroinflammation via mechanisms that are triggered by adduct formation with thiol redox switches.
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Scooped by Gilbert C FAURE
March 10, 2015 3:29 PM
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Public Release: 9-Mar-2015 Genetics breakthrough by group that includes UF ... - EurekAlert (press release)

Public Release: 9-Mar-2015 Genetics breakthrough by group that includes UF ... - EurekAlert (press release) | AUTOIMMUNITY | Scoop.it
The genes that increase the risk of Type 1 diabetes have lost their hiding place.
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Scooped by Gilbert C FAURE
March 22, 2015 12:59 AM
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Neuronal Antibody Biomarkers for Sydenham’s Chorea Identify a New Group of Children with Chronic Recurrent Episodic Acute Exacerbations of Tic and Obsessive Compulsive Symptoms Following a Streptoc...

Neuronal Antibody Biomarkers for Sydenham’s Chorea Identify a New Group of Children with Chronic Recurrent Episodic Acute Exacerbations of Tic and Obsessive Compulsive Symptoms Following a Streptoc... | AUTOIMMUNITY | Scoop.it
Several autoantibodies (anti-dopamine 1 (D1R) and 2 (D2R) receptors, anti-tubulin, anti-lysoganglioside-GM1) and antibody-mediated activation of calcium calmodulin dependent protein kinase II (CaMKII) signaling activity are elevated in children...
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Scooped by Gilbert C FAURE
March 20, 2015 9:23 PM
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Immunology may be key to pregnancy loss (updated) by Carolyn Coulam and Nancy Hemenway | INCIID

Immunology may be key to pregnancy loss (updated) by Carolyn Coulam and Nancy Hemenway | INCIID | AUTOIMMUNITY | Scoop.it
Reproductive Immunology: Key to Pregnancy Loss & Implantation Failure http://t.co/v2jBeGO2rv RT @INCIID
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Scooped by Gilbert C FAURE
March 20, 2015 12:13 PM
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Expression of Toll-Like Receptor -7 and -9 in B Cell Subsets from Patients with Primary Sjögren’s Syndrome

Expression of Toll-Like Receptor -7 and -9 in B Cell Subsets from Patients with Primary Sjögren’s Syndrome | AUTOIMMUNITY | Scoop.it
by Marie Karlsen, Torbjørn Hansen, Hilde H. Nordal, Johan G. Brun, Roland Jonsson, Silke Appel
Introduction Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by inflammation of exocrine glands.
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Scooped by Gilbert C FAURE
March 19, 2015 4:34 AM
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Autoimmunity conferred by chs3-2D relies on CSA1, its adjacent TNL-encoding neighbour : Scientific Reports : Nature Publishing Group

Autoimmunity conferred by chs3-2D relies on CSA1, its adjacent TNL-encoding neighbour : Scientific Reports : Nature Publishing Group | AUTOIMMUNITY | Scoop.it
Plant innate immunity depends on the function of a large number of intracellular immune receptor proteins, the majority of which are structurally similar to mammalian nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) proteins.
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Scooped by Gilbert C FAURE
March 15, 2015 3:17 PM
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Database on healthy immune system developed

Database on healthy immune system developed | AUTOIMMUNITY | Scoop.it
An extensive database identifying immune traits, such as how immune cell function is regulated at the genetic level in healthy people, has been developed by researchers.
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Scooped by Gilbert C FAURE
March 14, 2015 10:46 AM
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Regulation of Autoimmune Germinal Center Reactions in Lupus-Prone BXD2 Mice by Follicular Helper T Cells

Regulation of Autoimmune Germinal Center Reactions in Lupus-Prone BXD2 Mice by Follicular Helper T Cells | AUTOIMMUNITY | Scoop.it
by Young Uk Kim, Hoyong Lim, Ha Eun Jung, Rick A. Wetsel, Yeonseok Chung
BXD2 mice spontaneously develop autoantibodies and subsequent glomerulonephritis, offering a useful animal model to study autoimmune lupus.
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Suggested by Société Francaise d'Immunologie
March 14, 2015 10:41 AM
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Interleukin-10+ regulatory B cells arise within antigen-experienced... - PubMed - NCBI

Diabetes. 2015 Jan;64(1):158-71. doi: 10.2337/db13-1639. Epub 2014 Sep 3. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Scooped by Gilbert C FAURE
March 13, 2015 3:18 PM
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Monoclonal antibody treatment for T1D

Monoclonal antibody treatment for T1D | AUTOIMMUNITY | Scoop.it
More pharma news ... BioLineRx says it has positive pre-clinical results for a drug called BL-9020, a novel monoclonal antibody treatment for Type 1 diabetes. From Smarter Analyst: BL-9020 is a nov...
Gilbert C FAURE's insight:

BL-9020 targets NKp46, a unique target that is involved in the innate response against the pancreas. Pre-clinical studies in mouse models of Type 1 diabetes suggest that BL-9020 can inhibit beta cell death, thus preventing full maturation of the disease. This effect could significantly delay, and potentially prevent, the need for chronic insulin use by Type 1 diabetes patients, as well as provide a potential benefit in minimizing diabetes-related complications.

The new set of experiments shows that BL-9020 led to decreased levels of its target, NKp46, on murine NK cells, and specifically reduces the cytotoxic activity mediated by NKp46 in these cells. 

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Scooped by Gilbert C FAURE
March 12, 2015 3:44 PM
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Examination of autoantibody status and clinical features that associate with cancer risk and cancer-associated scleroderma - Shah - Arthritis & Rheumatology - Wiley Online Library

Examination of autoantibody status and clinical features that associate with cancer risk and cancer-associated scleroderma - Shah - Arthritis & Rheumatology - Wiley Online Library | AUTOIMMUNITY | Scoop.it
Examination of autoantibody status & clinical feats that associate w/ cancer risk & cancer-assoc #scleroderma: http://t.co/MYEqbWhd9F
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Scooped by Gilbert C FAURE
March 11, 2015 2:57 PM
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No Irish register for disease - Irish Medical Times

No Irish register for disease - Irish Medical Times | AUTOIMMUNITY | Scoop.it
Clinical Update: It is believed that 1 per cent of people in northern Europe have coeliac disease and so 43,000 to 45,000 would be expected to have it here
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Scooped by Gilbert C FAURE
March 11, 2015 2:53 PM
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IPEX (Immunodysregulation, Polyendocrinopathy,Enteropathy, X-linked) - Type 1 diabetes mellitus - Diapedia, The Living Textbook of Diabetes

IPEX (Immunodysregulation, Polyendocrinopathy,Enteropathy, X-linked) - Type 1 diabetes mellitus - Diapedia, The Living Textbook of Diabetes | AUTOIMMUNITY | Scoop.it
IPEX is a very rare syndrome marked by aggressive autoimmunity and usually results in early death: http://t.co/syufgKmWks
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Scooped by Gilbert C FAURE
March 11, 2015 10:43 AM
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Promising celiac disease therapies on the horizon - Reuters UK

(Reuters Health) - Currently, a gluten free diet is the only way to manage celiac disease.
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