AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Suggested by Société Francaise d'Immunologie
March 22, 2014 3:39 PM
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Siglec-G Deficiency Leads to More Severe Collagen-Induced Arthritis and Earlier Onset of Lupus-like Symptoms in MRL/lpr Mice [AUTOIMMUNITY]

Siglec-G Deficiency Leads to More Severe Collagen-Induced Arthritis and Earlier Onset of Lupus-like Symptoms in MRL/lpr Mice [AUTOIMMUNITY] | AUTOIMMUNITY | Scoop.it
Siglec-G is a member of the sialic acid–binding Ig-like lectin (Siglec) family expressed on all B cells.
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Rescooped by Gilbert C FAURE from Top Selling Monoclonal Antibodies
March 22, 2014 2:44 PM
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Secukinumab, Novartis IL-17A inhibitor effective in 2 phase III psoriasis trials.

Secukinumab, Novartis IL-17A inhibitor effective in 2 phase III psoriasis trials. | AUTOIMMUNITY | Scoop.it

Pivotal phase III FEATURE and JUNCTURE studies met primary and pre-specified secondary endpoints, showing high efficacy with convenient pre-filled syringe (PFS) and autoinjector/pen (AI)[1],[2]Patient-reported outcomes from FEATURE and JUNCTURE show high patient satisfaction with secukinumab PFS and AI self-administration[3],[4]Data show patients rapidly achieved almost clear skin (PASI 90), consistent with head-to-head phase III FIXTURE psoriasis study where secukinumab showed superiority over Enbrel®* (etanercept)[5]Secukinumab is the first IL-17A inhibitor with phase III data presented and regulatory submissions filed with global health authorities


Via Krishan Maggon
Krishan Maggon 's curator insight, March 22, 2014 10:19 AM

The first IL-17a inhibitor mab achieved high skin clearance( PASI 90) in psoriasis patients, Novartis claim superior to Enbrel, not compared to Humira or Remicade?. BLA and MAA filed and is under regulatory review in the US and EU.

Gilbert C FAURE's comment, March 22, 2014 2:43 PM
thanks, got it et posted it yesterday http://www.marketwatch.com/story/novartis-announces-start-of-new-secukinumab-ain457-versus-stelarar-ustekinumab-phase-iiib-head-to-head-psoriasis-study-at-aad-2014-2014-03-21?reflink=MW_news_stmp through marketwatch
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March 18, 2014 2:29 PM
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Development of anti-citrullinated protein antibody and rheumatoid ...

Development of anti-citrullinated protein antibody and rheumatoid factor isotypes prior to the onset of rheumatoid arthritis. Wouter H Bos, Lotte A van de Stadt, Azita Sohrabian, Johan Rönnelid and Dirkjan van Schaardenburg ...
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March 17, 2014 2:14 PM
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Immunity - Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response
http://t.co/ul5cIkZZXS
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Scooped by Gilbert C FAURE
March 17, 2014 9:32 AM
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IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity

IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity - up-to-the-minute news and headlines.
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Scooped by Gilbert C FAURE
March 16, 2014 3:02 PM
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International Autoantibody Standardizing (IAS) Workshop

International Autoantibody Standardizing (IAS) Workshop | AUTOIMMUNITY | Scoop.it
Workshop International Autoantibody Standardizing (IAS) http://t.co/YwTttf2o74
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Scooped by Gilbert C FAURE
March 14, 2014 9:50 AM
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New Antibody Shows Promise in Lupus

New Antibody Shows Promise in Lupus | AUTOIMMUNITY | Scoop.it
Initial clinical studies of epratuzumab in patients with active, moderate-to-severe systemic lupus erythematosus are suggesting promise for this monoclonal antibody.
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Scooped by Gilbert C FAURE
March 13, 2014 11:34 PM
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Altered RIG-I/DDX58-mediated innate immunity in dermatomyositis - Suárez-Calvet - The Journal of Pathology - Wiley Online Library

Altered RIG-I/DDX58-mediated innate immunity in dermatomyositis - Suárez-Calvet - The Journal of Pathology - Wiley Online Library | AUTOIMMUNITY | Scoop.it
Altered RIG-I/DDX58-mediated innate immunity in dermatomyositis http://t.co/n7AYki85oL
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Scooped by Gilbert C FAURE
March 13, 2014 11:25 PM
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Microbial DNA may be involved in the development of autoimmune processes ... - News-Medical.net

Microbial DNA may be involved in the development of autoimmune processes ... - News-Medical.net | AUTOIMMUNITY | Scoop.it
Microbial DNA may be involved in the development of autoimmune processes ...
Gilbert C FAURE's insight:
type I diabetes in BABYDIeT study
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March 12, 2014 6:19 AM
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Rare Double Infection: Lupus Patient Makes Antibodies to Fight HIV - LiveScience.com

Rare Double Infection: Lupus Patient Makes Antibodies to Fight HIV - LiveScience.com | AUTOIMMUNITY | Scoop.it
LiveScience.com Rare Double Infection: Lupus Patient Makes Antibodies to Fight HIV LiveScience.com The researchers found that in response to her HIV, the woman's immune system produced what are called "broadly neutralizing antibodies," which are...
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March 12, 2014 2:58 AM
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Antibody Linked to Celiac Disease That Does Not Respond To Gluten-Free Diet

Antibody Linked to Celiac Disease That Does Not Respond To Gluten-Free Diet | AUTOIMMUNITY | Scoop.it
A new study, with contributions made from two CDF Medical Advisory Board Members, Martin Kagnoff and Joseph A. Murray, has identified antibody biomarkers that can be potentially used to diagnose no...
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March 11, 2014 12:33 AM
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Serologic autoimmunologic parameters in women with primary ovarian ... - 7thSpace Interactive (press release)

Serologic autoimmunologic parameters in women with primary ovarian ...
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March 11, 2014 12:31 AM
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Unraveling the Equine Lymphocyte Proteome: Differential Septin 7 Expression Associates with Immune Cells in Equine Recurrent Uveitis

Unraveling the Equine Lymphocyte Proteome: Differential Septin 7 Expression Associates with Immune Cells in Equine Recurrent Uveitis | AUTOIMMUNITY | Scoop.it
by Roxane L. Degroote, Stefanie M. Hauck, Barbara Amann, Sieglinde Hirmer, Marius Ueffing, Cornelia A. Deeg
Equine recurrent uveitis is a spontaneous, lymphocyte-driven autoimmune disease.
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March 22, 2014 2:46 PM
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Highlighted article - February - Clinical Immunology - Elsevier

Highlighted article - February - Clinical Immunology - Elsevier | AUTOIMMUNITY | Scoop.it
SLAP deficiency decreases dsDNA autoantibody production (Lisa K. Peterson)

Lisa K. Peterson, Luke F. Pennington, Laura A. Shaw, Meredith Brown...
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Scooped by Gilbert C FAURE
March 19, 2014 7:21 AM
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BMC Medicine | Full text | Open questions in autoimmunity: discussions from the 2013 Controversies in Rheumatology and Autoimmunity Meeting

The recent CORA (Controversies in Rheumatology and Autoimmunity) meeting held in 2013 represented a unique opportunity for rheumatologists to address several topics.
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Scooped by Gilbert C FAURE
March 18, 2014 9:05 AM
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Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice

Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice | AUTOIMMUNITY | Scoop.it
by Elizabeth M. Samuelson, Renee M. Laird, Amber M. Papillion, Arthur H. Tatum, Michael F. Princiotta, Sandra M.
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Scooped by Gilbert C FAURE
March 17, 2014 9:42 AM
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Access : The etiology of glomerulonephritis: roles of infection and autoimmunity : Kidney International

Kidney International aims to inform the renal researcher and practicing nephrologists on all aspects of renal research. Clinical and basic renal research, commentaries, The Renal Consult, Nephrology sans Frontieres, minireviews, reviews, Nephrology Images, Journal Club. Published weekly online and twice a month in print.
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March 16, 2014 3:03 PM
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Autoantibodies to Agrin in Myasthenia Gravis Patients

Autoantibodies to Agrin in Myasthenia Gravis Patients | AUTOIMMUNITY | Scoop.it
by Bin Zhang, Chengyong Shen, Beverly Bealmear, Samia Ragheb, Wen-Cheng Xiong, Richard A. Lewis, Robert P.
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March 16, 2014 2:52 PM
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Arthritis Research & Therapy | Abstract | The classification of ...

In recent years, there has been an increase demand for computer-aided diagnosis (CAD) tools to support clinicians in the field of indirect immunofluorescence. To this aim, academic and industrial research is focusing on ...
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March 13, 2014 11:37 PM
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Self-Antigen Presentation by Dendritic Cells i... [Front Immunol. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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March 13, 2014 11:26 PM
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Spatial Environmental Modeling of Autoantibody ... - MDPI.com

Spatial Environmental Modeling of Autoantibody ... - MDPI.com | AUTOIMMUNITY | Scoop.it
In this study of autoimmunity among a population of Gullah African Americans in South Carolina, the links between environmental exposures and autoimmunity (presence of antinuclear antibodies (ANA)) have been assessed.
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March 13, 2014 9:13 AM
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Compromised gut microbiota networks in children with anti-islet cell ...

Evidence of anti-islet cell autoimmunity in type 1 diabetes appears in the first years of life, however little is known regarding establishment of the gut microbiome in early infancy. Here, we sought to ...
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Scooped by Gilbert C FAURE
March 12, 2014 4:50 AM
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Beta-Endorphin 1–31 Biotransformation and cAMP Modulation in Inflammation

Beta-Endorphin 1–31 Biotransformation and cAMP Modulation in Inflammation | AUTOIMMUNITY | Scoop.it
by Naghmeh Hajarol Asvadi, Michael Morgan, Herath M. Herath, Amitha K. Hewavitharana, P. Nicholas Shaw, Peter J.
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March 11, 2014 10:28 PM
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Type 1 diabetes in adults: Antibody affinity is decisive

Type 1 diabetes in adults: Antibody affinity is decisive http://t.co/INzDzvtNfs
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Scooped by Gilbert C FAURE
March 11, 2014 12:33 AM
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Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression

Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression http://t.co/p85TkaaQBC #JEMTCB
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