AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
March 10, 2014 10:01 PM
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Autoimmune Basis for Postural Tachycardia Syndrome (POTS) - ProHealth

Autoimmune Basis for Postural Tachycardia Syndrome (POTS) - ProHealth | AUTOIMMUNITY | Scoop.it
Autoimmune Basis for Postural Tachycardia Syndrome (POTS) ProHealth Background: Patients with postural tachycardia syndrome (POTS) have exaggerated orthostatic tachycardia often following a viral illness, suggesting autoimmunity may play a...
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Suggested by Société Francaise d'Immunologie
March 10, 2014 8:24 AM
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The DC-HIL/Syndecan-4 Pathway Regulates Autoimmune Responses through Myeloid-Derived Suppressor Cells [AUTOIMMUNITY]

The DC-HIL/Syndecan-4 Pathway Regulates Autoimmune Responses through Myeloid-Derived Suppressor Cells [AUTOIMMUNITY] | AUTOIMMUNITY | Scoop.it
Having discovered that the dendritic cell (DC)–associated heparan sulfate proteoglycan–dependent integrin ligand (DC-HIL) receptor on APCs inhibits T cell activation by binding to syndecan-4 (SD-4) on T cells, we hypothesized that the DC-HIL/SD-4...
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Scooped by Gilbert C FAURE
March 9, 2014 12:44 AM
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Characterisation of Leukocytes in a Human Skin Blister Model of Acute Inflammation and Resolution

Characterisation of Leukocytes in a Human Skin Blister Model of Acute Inflammation and Resolution | AUTOIMMUNITY | Scoop.it
by William Jenner, Madhur Motwani, Kristin Veighey, Justine Newson, Tatsiana Audzevich, Anna Nicolaou, Sharon Murphy, Raymond MacAllister, Derek W.
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Scooped by Gilbert C FAURE
March 7, 2014 3:19 AM
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Genes and Immunity - MHC associations with clinical and autoantibody manifestations in European SLE

Genes and Immunity - MHC associations with clinical and autoantibody manifestations in European SLE | AUTOIMMUNITY | Scoop.it
Genes and Immunity is a journal dedicated to functional genetics of the immune response. Emphasizing studies that demonstrate genetic, genomic or functional variation in the immune system, Genes and Immunity assists our understanding of how the basic control over the immune system varies between individuals both in health and disease.
Gilbert C FAURE's insight:

They found evidence of associations independent of MHC class II variants in the anti-Ro subset alone. Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies.

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Scooped by Gilbert C FAURE
March 6, 2014 1:17 PM
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JCI - Lymphatic vessels and tertiary lymphoid organs

Tertiary lymphoid organs (TLOs) are accumulations of lymphoid cells in chronic inflammation that resemble LNs in their cellular content and organization, high endothelial venules, and lymphatic vessels (LVs).
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Scooped by Gilbert C FAURE
March 5, 2014 1:12 PM
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CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes - Europe PMC Article - Europe PubMed Central

Author: Haskins K, Journal: Current opinion in immunology[2011/12], Abstract: Pathogenesis of type 1 diabetes (T1D) is mediated by effector T cells and CD4 Th1 and Th17T cells have important roles in this process.
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2011

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Scooped by Gilbert C FAURE
March 5, 2014 1:06 PM
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Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment

The Journal of Allergy and Clinical Immunology, Volume null, Issue null, Pages null, null, Authors:Yu Zhang, PhD; Xiaomin Yu, PhD; Mie Ichikawa, BSc; Jonathan J. Lyons, MD; Shrimati Datta, PhD; Ian T.
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Scooped by Gilbert C FAURE
March 4, 2014 4:39 AM
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Emerging biological therapies for systemic lupus erythematosus, Expert Opinion on Emerging Drugs, Informa Healthcare

Emerging biological therapies for systemic lupus erythematosus, Expert Opinion on Emerging Drugs, Informa Healthcare | AUTOIMMUNITY | Scoop.it
Emerging biological therapies for systemic lupus erythematosus http://t.co/3tY521KnXz
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Scooped by Gilbert C FAURE
March 3, 2014 1:51 PM
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BMC Medicine | Full text | Automated tests of ANA immunofluorescence as throughput autoantibody detection technology: strengths and limitations

Anti-nuclear antibody (ANA) assay is a screening test used for almost all autoimmune rheumatic diseases, and in a number of these cases, it is a diagnostic/classification parameter.
Gilbert C FAURE's insight:

Current evidence from preliminary study results indicates that there is good correlation between manual and automated interpretation of ANA IIF assays, at least in the ability to discriminate between positive and negative results and in recognizing the main IIF patterns. Such systems will therefore speed up routine performance of these tests and help to harmonize interpretation of the results across laboratories. However, there is a need to have their clinical diagnostic power validated by clinical studies, in addition to the analytical studies that have already been published. In addition, these new systems could be further improved if they were better able to recognize mixed fluorescent or less common fluorescent patterns.

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Scooped by Gilbert C FAURE
March 2, 2014 6:36 AM
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Autoantibody Titers Predict Disease Activity in Autoimmune Hepatitis

Persistent high titers of ASMA and F-actin were associated with biochemical and histologic disease activity in a longitudinal study.
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Scooped by Gilbert C FAURE
March 2, 2014 6:35 AM
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Australian researchers identify new cell pathway that controls ...

Australian researchers identify new cell pathway that controls ... | AUTOIMMUNITY | Scoop.it
Until now, there has been no recognised pathway for immune cells to travel through the brain to carry out routine 'surveillance' to protect against autoimmune attack. Associate Professor Brown has identified a specific pathway ...
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Scooped by Gilbert C FAURE
March 2, 2014 5:18 AM
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Arthritis Research & Therapy | Full text | Cathelicidin antimicrobial ...

Human cathelicidins are involved in mucosal immunity of the respiratory tract, gastrointestinal tract, genitourinary tract, and eye [10]. Human cathelicidin is overexpressed in head and neck squamous cell carcinoma, and is ...
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Scooped by Gilbert C FAURE
February 26, 2014 2:13 PM
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Autoantibodies against MHC class I polypeptide-related sequence A are ... - 7thSpace Interactive (press release)

Autoantibodies against MHC class I polypeptide-related sequence A are ...
7thSpace Interactive (press release)
Overexpression of autologous proteins can lead to the formation of autoantibodies and autoimmune diseases.
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Scooped by Gilbert C FAURE
March 10, 2014 8:25 AM
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AbbVie's Humira Still a Growth Engine - Motley Fool

AbbVie's Humira Still a Growth Engine Motley Fool Humira – like Johnson & Johnson's Remicade – is a manufactured monoclonal antibody that treats autoimmune diseases by interfering with (blocking) tumor necrosis factor (TNF), an inflammatory protein...
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Scooped by Gilbert C FAURE
March 10, 2014 8:24 AM
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QATDJXsIEw

Frequency of Intrinsic Factor Antibody in Megaloblastic Anaemia - http://t.co/QATDJXsIEw
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Scooped by Gilbert C FAURE
March 9, 2014 12:43 AM
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Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort -- Hacohen et al. 85 (4): 456 -- Journal of Neurology, Neurosurgery & Psychiatry

Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort http://t.co/wpWirtihmH
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Scooped by Gilbert C FAURE
March 7, 2014 3:13 AM
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In the Beginning Was Sm

In the Beginning Was Sm | AUTOIMMUNITY | Scoop.it
RT @hausmannMD: Everything you wanted to know about the anti-Smith antibody, but were afraid to ask. http://t.co/TKzC8o1upf #lupus #rheum
Gilbert C FAURE's insight:

The serum came from Stephanie Smith, who was diagnosed with SLE at the age of 15 in 1959 at the Rockefeller University Hospital, where she presented with arthritis, rash, pleuritis positive lupus erythematosus preparation, complement-fixing Abs with cell nuclei and cytoplasm, elevated sedimentation rate, γ-globulin, and anemia without renal disease. Stephanie succumbed to complications of her disease and treatment 7 years later at the age of 22.

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Scooped by Gilbert C FAURE
March 6, 2014 1:16 PM
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Altered RIG-I/DDX58-mediated innate immunity in dermatomyositis - Suárez-Calvet - The Journal of Pathology - Wiley Online Library

Altered RIG-I/DDX58-mediated innate immunity in dermatomyositis - Suárez-Calvet - The Journal of Pathology - Wiley Online Library | AUTOIMMUNITY | Scoop.it
J Pathol: Altered RIG-I/DDX58-mediated innate immunity in dermatomyositis: We investigated the molecular mecha... http://t.co/PdRM0UzYIN
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Scooped by Gilbert C FAURE
March 5, 2014 1:07 PM
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Th1 Response and Systemic Treg Deficiency in Inclusion Body Myositis

Th1 Response and Systemic Treg Deficiency in Inclusion Body Myositis | AUTOIMMUNITY | Scoop.it
by Yves Allenbach, Wahiba Chaara, Michelle Rosenzwajg, Adrien Six, Nicolas Prevel, Federico Mingozzi, Julia Wanschitz, Lucile Musset, Jean-Luc Charuel, Bruno Eymard, Benoit Salomon, Charles Duyckaerts, Thierry Maisonobe, Odile Dubourg, Serge...
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Scooped by Gilbert C FAURE
March 4, 2014 10:39 AM
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NIH Team Identifies New Genetic Syndrome - HealthCanal.com

NIH Team Identifies New Genetic Syndrome - HealthCanal.com | AUTOIMMUNITY | Scoop.it
NIH Team Identifies New Genetic Syndrome HealthCanal.com WHAT: Researchers at the National Institutes of Health (NIH) have identified a new genetic syndrome characterized by a constellation of health problems, including severe allergy, immune...
Gilbert C FAURE's insight:

By studying this group, the investigators found that the syndrome is caused by mutations in the PGM3 gene that result in the production of underactive PGM3 protein. The NIH team showed that underactive PGM3 leads to lower levels of sugars that are essential for glycosylation, or the attachment of sugars to proteins. Glycosylation is necessary for the normal growth and function of all tissues and organs in the human body. The variety of symptoms in people with PGM3 mutations likely reflects the production of abnormally glycosylated proteins throughout the body. In the laboratory, adding a certain type of sugar to cells from patients with PGM3 mutations boosted cellular levels of the sugars necessary for glycosylation, thus suggesting a potential treatment.

Sugars on stage

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Scooped by Gilbert C FAURE
March 3, 2014 1:52 PM
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Chronic Exposure to Oral Pathogens and Autoimmune Reactivity in ...

Subjects with acute coronary artery atherothrombosis showed very strong autoimmune response with elevation in antiendothelial cell IgG antibodies in the group (45% versus 23%, O.R. 2.73, 95% CI for OR 1.48–5.04, RR ...
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Scooped by Gilbert C FAURE
March 2, 2014 6:40 AM
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Granulocyte-dependent Autoantibody-induced Skin Blistering

To watch this video on jove.com, click here: http://www.jove.com/video/4250?utm_source=youtube In the animal model described in our present work, purified Ig...
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Scooped by Gilbert C FAURE
March 2, 2014 6:36 AM
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Circulating levels of soluble MER in lupu... [Arthritis Res Ther. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Suggested by Société Francaise d'Immunologie
March 2, 2014 6:35 AM
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Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis

[Research Articles] Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis http://t.co/VGhVLBWHNV
Gilbert C FAURE's insight:

cytokine focused target

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Scooped by Gilbert C FAURE
February 28, 2014 1:51 PM
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Studies from Scripps Research Institute in the Area of Mononuclear Phagocyte System Reported

Studies from Scripps Research Institute in the Area of Mononuclear Phagocyte System Reported | AUTOIMMUNITY | Scoop.it
Immunology News Article - Studies from Scripps Research Institute in the Area of Mononuclear Phagocyte System Reported (Immunology: Studies from Scripps Research Institute in the Area of Mononuclear Phagocyte System Reported
Gilbert C FAURE's insight:

lupus oriented, but mice model

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