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Whole Transcriptome Analysis (RNA Sequencing) of Peripheral Blood Mononuclear Cells of Vitiligo Patients http://t.co/SyNTVScgTe 
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But serious adverse events remain frequent, regardless of treatment method
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Engineering mice to identify autoreactive T-cell antigens Nature.com Whereas autoantibody targets are relatively easy to identify in autoimmune diseases, the autoantigen targets of pathogenic T cells that might be central to rheumatoid arthritis...
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Kidney International aims to inform the renal researcher and practicing nephrologists on all aspects of renal research.
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Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL ...
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Researchers show that the prevalence of one genus of bacteria correlates with the onset of rheumatoid arthritis.
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Tilli Tansey surveys a magisterial, historically rich biography of autoimmunity.
Gilbert C FAURE's insight:
a book Intolerant Bodies: A Short History of Autoimmunity Warwick Anderson and Ian R. Mackay Johns Hopkins University Press: 2014. ISBN: 9781421415338
Gilbert C FAURE's curator insight,
November 1, 2014 11:55 AM
a book Intolerant Bodies: A Short History of Autoimmunity Warwick Anderson and Ian R. Mackay Johns Hopkins University Press: 2014. ISBN: 9781421415338
"It has been calculated that in any population, 5–10% of people — a large proportion of them women — will at some point have an autoimmune disease. Intolerant Bodies, by the medically trained historian Warwick Anderson and clinical immunologist Ian Mackay, draws on medical, scientific, historical and literary sources to highlight four such conditions: type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis. The term autoimmune first appeared in 1951, and autoimmunity in 1957, although neither was then — or now — universally accepted. Some immunologists continue to prefer 'autoallergy'; the late Robin Coombs, inventor of the first specific test for red-cell antibodies, declared that he would “go down fighting” in his opposition to 'autoimmune'." 
LIGHTING 's comment,
November 1, 2014 1:06 PM
t has been calculated that in any population, 5–10% of people — a large proportion of them women — will at some point have an autoimmune disease. Intolerant Bodies, by the medically trained historian Warwick Anderson and clinical immunologist Ian Mackay, draws on medical, scientific, historical and literary sources to highlight four such conditions: type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis.
The term autoimmune first appeared in 1951, and autoimmunity in 1957, although neither was then — or now — universally accepted. Some immunologists continue to prefer 'autoallergy'; the late Robin Coombs, inventor of the first specific test for red-cell antibodies, declared that he would “go down fighting” in his opposition to 'autoimmune'. Mackay and Anderson focus less on the heyday of autoimmunity in the past few decades than on its 'prehistory' and emergence as a defined field of medical research and practice. Early-nineteenth-century studies of fevers led to the recognition that the body's own physiological responses could be harmful, and germ theory later that century spurred knowledge of the body's defence mechanisms. Medical luminaries such as Robert Koch and Joseph Lister struggled to understand basic mechanisms and isolate causative agents. In the 1880s, the Russian biologist Élie Metchnikoff argued that circulating cells, the phagocytes, digested invading cells. In the first half of the twentieth century, in public-health labs and early pharmaceutical companies, the development of serotherapy — treating infectious diseases such as diphtheria by injecting serum raised in an immunized animal — stimulated much research on the immune system. The authors emphasize how after the Second World War, an increase in government and private funding led to the expansion of research laboratories, including Henry Kunkel's at the Rockefeller Institute in New York City, Macfarlane Burnet's at the Walter and Eliza Hall Institute in Melbourne, Australia, and those at industrial concerns such as pharmaceutical giant Merck. Researchers developed tools, techniques and languages based on cellular and molecular approaches. In Britain, Peter Medawar unravelled the mechanisms of rejection after tissue transplantation. In New York City, Jules Freund demonstrated that an emulsion of paraffin oil and dead mycobacteria, the causative organisms of tuberculosis, enhanced and prolonged immune reactions in animal models of disease. Burnet, who shared a Nobel prize with Medawar in 1960, recognized Freund's contribution as key to the experimental study of autoimmunity. The subject was now high on the agenda of many biomedical scientists. Work on subsets of lymphocytes, human-tissue antigens and the genetics of histocompatibility factors all contributed to the understanding of cellular mechanisms, and to devising diagnostic and therapeutic strategies for an array of disorders.
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RT @PaulWhiteleyPhD: Anti-NMDA receptor encephalitis, autoimmunity, and psychosis http://t.co/bR6sCipiVu Mmm... http://t.co/0r4rbyrUsl
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In Autoimmune Diseases Affecting Millions, Researchers Pinpoint Genetic Risks ...
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Curr Hypertens Rep. 2014 Apr;16(4):424. doi: 10.1007/s11906-014-0424-1. Research Support, Non-U.S. Gov't; Review
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collaboration & networking platform for physicians around the world
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Degli-Esposti & co show regulatory NK cell activity limits autoimmunity in chronic viral infection http://t.co/o2gI6c2BUI
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Abstract Via Krishan Maggon
Krishan Maggon 's curator insight,
October 28, 2014 2:38 AM
Insulin like Growth factor 1 could suppress activated immune system in multiple sclerosis, slow down myelin destruction and delay disease progression. Active in EAE model, next step clinical trials.
open access EMBO Mol Med. 2014 Oct 22. pii: e201303376. doi: 10.15252/emmm.201303376. [Epub ahead of print]Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.Bilbao D1, Luciani L2, Johannesson B2, Piszczek A2, Rosenthal N3. |
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Diabetes. 2014 Nov 5. pii: DB_141145. [Epub ahead of print]
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Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and… http://t.co/wwTZaPSd4b #jimmTCB
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Although genome-wide association studies (GWAS) have identified hundreds of variants associated with a risk for autoimmune and immune-related disorders (AID), our understanding of the disease mechanisms is still limited.
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by Jamie L. Harden, Steven M. Lewis, Katherine C. Pierson, Mayte Suárez-Fariñas, Tim Lentini, Francesca S. Ortenzio, Lisa C. Zaba, Raphaela Goldbach-Mansky, Anne M. Bowcock, Michelle A.
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Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystemic disorder, belonging to the small vessel ANCA-associated vasculitis, defined as a eosinophil-rich and necrotizing granulomatous inflammation often involving the respiratory...
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Eur J Immunol. 2014 Oct 29. doi: 10.1002/eji.201444760. [Epub ahead of print]
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Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.
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Epigenetics. 2014 Feb;9(2):276-85. doi: 10.4161/epi.27021. Epub 2013 Nov 8. Research Support, N.I.H., Extramural
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Patients with the autoimmune polyendocrine syndrome type I (APS-I), caused by mutations in the autoimmune regulator (AIRE) gene, and myasthenia gravis (MG) with thymoma, show intriguing but unexplained parallels.
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Blood. 2014 Oct 27. pii: blood-2014-04-570101. [Epub ahead of print]
Gilbert C FAURE's insight:
Abstract
The signal transducer and activator of transcription (STAT) family of transcription factors orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development of IPEX-like syndrome. Here, we immunologically characterized three patients with de novo activating mutations in the DNA binding or dimerization domains of STAT3 (p.K392R, p.M394T and p.K658N, respectively). The patients displayed multi-organ autoimmunity, lymphoproliferation, and delayed-onset mycobacterial disease. Immunologically, we noted hypogammaglobulinemia with terminal B cell maturation arrest, dendritic cell deficiency, peripheral eosinopenia, increased double-negative (CD4-CD8-
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A major barrier to treating autoimmune diseases such as Type 1 diabetes is the lack of methods to deliver the therapeutics to specific sites such as the lymph nodes.
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C4 Deficiency Is a Predisposing Factor for Streptococcus pneumoniae–Induced Autoantibody Production http://t.co/wO5lbEHL5Y #inmuva
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Using functional analysis, altogether 993 associations between the gene groups and diseases were found. The analysis revealed associations between vitiligo and diseases such as lichen planus, limb-girdle muscular dystrophy type 2B, and facioscapulohumeral muscular dystrophy. Additionally, the gene groups with an altered expression pattern are participating in processes such as cell death, survival and signaling, inflammation, and oxidative stress. In conclusion, vitiligo is rather a systemic than a local skin disease; the findings from an enormous amount of RNA sequencing data support the previous findings about vitiligo and should be further analyzed.