Step into the dimly lit Victorian lab of 1885, where a young scientist stands alongside Louis Pasteur, unraveling the secrets of diseases that once haunted humanity. 🧪 From extracting spinal tissue from rabbits to administering groundbreaking rabies vaccines, witness the rise of a new era in medicine. This is the story of perseverance, innovation, and the birth of modern immunology. Join us on this historical journey and discover how bravery and science can change the world forever!
Professor Stuart Tangye, Head of Garvan's Immunology Division, give an introduction to immunology. It includes a history of immunology, what the immune system is, diseases related to the immune system and some detailed information about his research. To find out more: https://www.garvan.org.au/research/diseases/immunodeficiency/our-research
Substantial progress in understanding T cell signalling, particularly with respect to T cell co-receptors such as the co-stimulatory receptor CD28, has been made in recent years. This knowledge has been instrumental in the development of innovative immunotherapies for patients with cancer, including immune checkpoint blockade antibodies, adoptive cell therapies, tumour-targeted immunostimulatory antibodies, and immunostimulatory small-molecule drugs that regulate T cell activation. Following the failed clinical trial of a CD28 superagonist antibody in 2006, targeted CD28 agonism has re-emerged as a technologically viable and clinically promising strategy for cancer immunotherapy. In this Review, we explore recent insights into the molecular functions and regulation of CD28. We describe how CD28 is central to the success of current cancer immunotherapies and examine how new questions arising from studies of CD28 as a clinical target have enhanced our understanding of its biological role and may guide the development of future therapeutic strategies in oncology. This Review covers recent advances in our understanding of CD28 co-stimulation of T cells and discusses an emerging paradigm that positions CD28 as central to the success of current and future immunotherapeutic approaches to treating cancer.
NK cells were first described five decades ago and named in 1975. This brief Perspective highlights a timeline of a few selected advancements in NK cell bi
Nous sommes nombreux luttant contre la désinformation scientifique, à constater la proximité des principales figures complotistes et antivax avec les milieux…
Join me with Dr. Walter Bodmer to discuss genetics and the future of cancer research. Walter Bodmer assumed his current position at the Weatherall Institute of Molecular Medicine as Head of the Cancer and Immunogenetics laboratory and more recently within the Department of Oncology.
We mourn the loss of Stuart Schlossman, the outstanding and impactful pioneer of human T cell immunology. Born in Brooklyn, New York, Stuart peacefully passed away on 13 August 2023, in Palm Beach Gardens, Florida.
Revisit ASGCT's Giants of Gene Therapy #podcast—now live on YouTube: https://bit.ly/49rb0OR. Hear Hans-Peter Kiem, MD, PhD, in one-on-one conversations with…
#Retiring is never easy. Especially not, when your job is rather a lifetime profession and you are doing it with passion, enthusiasm and… | 10 comments on LinkedIn
Le virus SARS-CoV-2 possède des caractéristiques génétiques très particulières, qui le distinguent des autres coronaviridae et même des deux autres membre du sous-genre des sarbécovirus, SARS-CoV (2002) et MERS (2012).
The 20th century was a dangerous time to be young: a multitude of diseases too often kept children from reaching even their teenage years. Millions suffered…
How was the hundredth anniversary of the smallpox vaccine celebrated? A ton of folks got vaccinated - too help control a smallpox epidemic in the least…
Effective antibody responses are essential to generate protective humoral immunity. Different inflammatory signals polarize T cells towards appropriate effector phenotypes during an infection or immunization.
8 juin 1940 - 12 décembre 2023 Élu correspondant le 21 novembre 1977, puis membre le 20 mai 1985 Secrétaire perpétuel pour 2006-2015 et Secrétaire perpétuel honoraire depuis 2016 Section : Biologie humaine et sciences médicales Notice nécrologiqu
To get content containing either thought or leadership enter:
To get content containing both thought and leadership enter:
To get content containing the expression thought leadership enter:
You can enter several keywords and you can refine them whenever you want. Our suggestion engine uses more signals but entering a few keywords here will rapidly give you great content to curate.
Your new post is loading...
Scoop.it!
