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RT @GreenJournal: Call for papers: Neurology: Neuroimmunology & Neuroinflammation, a new Neurology journal http://t.co/UQKIyBefkd #Neurology 
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Gilbert C FAURE's insight:
These data describe an immune cell pathway that originates in the CNS and is capable of dampening anti-CNS immune responses in the periphery. Furthermore, these data provide insight into how fingolimod treatment might exacerbate CNS neuroinflammation in some cases and suggest that focal therapeutic interventions, outside the CNS have the potential to selectively modify anti-CNS immunity.
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Cerebrospinal fluid detection of interleukin-1beta in phase of remission predicts disease progression in MS http://t.co/dtEcPsmg0B via @MS
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Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and arises from developing sympathetic nervous system. Most primary tumors localize in the abdomen, the adrenal gland or lumbar sympathetic ganglia.
Conclusion Progress in the understanding of NB cell biology will allow a more accurate stratification of patients, thus reducing toxic side effects of aggressive therapy in low-risk patients. High-risk patients who currently have a dismal prognosis could benefit from multidisciplinary therapeutic protocols that include novel NK cell-based immunotherapeutic strategies. The latter will take advantage of our knowledge about the presence/absence of NB-associated ligands interacting with activating/inhibitory receptors expressed by NK cells. Moreover, it should also take into account the multiple immunomodulatory strategies set up by NB and various immune cell types to impair the recruitment and activation of NK cells in the tumor microenvironment. The encouraging results emerged from haploidentical hematopoietic cell transplantation in pediatric hematological malignancies, might strongly motivate a re-evaluation of transplant approaches in the therapy of high-risk NB patients. - See more at: http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00056/full#sthash.6ZPzQhzp.dpuf Via Krishan Maggon
Krishan Maggon 's curator insight,
February 24, 2014 9:41 AM
Full text open access article Review ARTICLEFront. Immunol., 12 February 2014 | doi: 10.3389/fimmu.2014.00056Natural killer cells and neuroblastoma: tumor recognition, escape mechanisms, and possible novel immunotherapeutic approachesCristina Bottino1,2, Alessandra Dondero1, Francesca Bellora1, Lorenzo Moretta2, Franco Locatelli3,4, Vito Pistoia2, Alessandro Moretta1,5* and Roberta Castriconi1,51Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy2Istituto Giannina Gaslini, Genova, Italy3Dipartimento di Onco-Ematologia Pediatrica, Ospedale Bambino Gesù, Roma, Italy4Università di Pavia, Pavia, Italy5Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova, Genova, Italy - See more at: http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00056/full#sthash.6ZPzQhzp.dpuf
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Reference Ranges Established for Automated Cerebrospinal Fluid Cell Count Image: The ADVIA 2120i Hematology System with Autoslide (Photo courtesy of.
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:
Several variants of MS (and CNS demyelinating syndromes in general) have been nowadays defined in an effort to increase the diagnostic accuracy, to identify the unique immunopathogenic profile and to tailor treatment in each individual patient. These include the initial events of demyelination defined as clinically or radiologically isolated syndromes (CIS and RIS respectively), acute disseminated encephalomyelitis (ADEM) and its variants (acute hemorrhagic leukoencephalitis-AHL, Marburg variant, and Balo's concentric sclerosis), Schilder's sclerosis, transverse myelitis, neuromyelitis optica (NMO and NMO spectrum of diseases), recurrent isolated optic neuritis and tumefactive demyelination.
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Absence of clinical and radiological activity in relapsing-remitting multiple sclerosis (RRMS) is perceived as disease remission. We explored the role of persisting inflammation during remission in disease evolution.
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Multiple Sclerosis Among Top Research Topics For “Year of the Brain” in Europe BioNews Texas European Brain Council The European Brain Council (EBC) has declared 2014 the “Year of the Brain,” with Multiple Sclerosis as a main research focus for the...
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Hyperactivity of our immune system can cause a state of chronic inflammation. If chronic, the inflammation will affect our body and result in disease.
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The overlap between #NMO and #NMDAR-encephalitis #neuroimmunology http://t.co/HVB0Wj07ut
Gilbert C FAURE's insight:
Interpretation: Patients with anti-NMDAR encephalitis may develop concurrent or separate episodes of demyelinating disorders, and conversely patients with NMO or demyelinating disorders with atypical symptoms (e.g., dyskinesias, psychosis) may have anti-NMDAR encephalitis. ANN NEUROL 2014. © 2014 American Neurological Association
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Serum antibody found in ~50% of adults with #multiplesclerosis found in children with acquired demyelinating disease http://t.co/vdu8iGkDT7
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eMaxHealth Resolution of inflammation is altered in Alzheimer's disease News-Medical.net A study published in the journal Alzheimer's & Dementia shows that levels in the brain and cerebrospinal fluid of the molecules necessary for tissue recovery...
Gilbert C FAURE's insight:
resolution of inflammation is the new field of inflammation reserarch
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Hyperactivity of our immune system can cause a state of chronic inflammation. If chronic, the inflammation will affect our body and result in disease. In the devastating disease multiple sclerosis, hyperactivity of immune cells called T-cells induce chronic inflammation and degeneration of the brain. Researchers at BRIC, the University of Copenhagen, have identified a new type of regulatory blood cells that can combat such hyperactive T-cells in blood from patients with multiple sclerosis.
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The aim of this blog is to comment top studies, relevant discoveries and scientific milestones in the NeuroImmunology field. The ultimate goal is to create a community of neuroimmunologists and a ...
Gilbert C FAURE's insight:
a blog on neuroimmunology by a spanish fellow in neuroimmunology
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ImmunoCellular Therapeutics Receives Orphan Drug Status for ICT-107 in ...
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Page Details (Find out How Imaris was used to quantify Morphology changes of Choroid Plexus after Immune Cells invade the CNS http://t.co/FueBPaAqiI)...
Gilbert C FAURE's insight:
The researchers are using the experimental autoimmune encephalomyelitis (EAE) animal model of multiple sclerosis to study the choroid plexus. They determined the gene expression patterns in the separate choroid plexus compartments in situ using laser capture microdissection and global RNA profiling. They turned to Imaris for the 3D morphological analysis because they had previously used it in a study that quantified capillary density and extent of branching within cerebral microvasculature.
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RT @PolygenicPaths: Potassium channel #autoantibody may be detectable in blood years before multiple sclerosis… http://t.co/2rJCtCcrwy
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Two publications from the same research group reporting on the detection of new possible biomarkers for the early diagnosis of Alzheimer’s disease (AD), based on the analysis of cerebrospinal fluid samples (CSF) with 1H Nuclear Magnetic Resonance...
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Background: The nucleotide-binding leucine-rich repeat (NLR) family of innate immune genes are important regulators of inflammatory responses in mammals. Results: The NLR gene, Nlrx1, suppresses neuroinflammation in ...
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Cerebrospinal fluid absorption (CSF) at the cribriform plate is mediated by direct extracranial connections to the lymphatic system.
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#PedBlood&Cancer Inflammatory disease of the central nervous system induced by anti-GD2 monoclonal antibody in... http://t.co/UfcZcxK86N
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However, no previous studies have measured β-arrestin 1 levels in peripheral blood mononuclear cells (PBMCs) in anxious/depressive rodents. This study aimed to develop a method to detect β-arrestin protein levels through ...
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BACKGROUND: Increased levels of antibodies to neurofilament light protein (NF-L) in biological fluids have been found to reflect neuroinflammatory responses and neurodegeneration in multiple sclerosis (MS).
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Genetic Engineering News Top 10 Multiple Sclerosis Drugs Genetic Engineering News Following is a list of 10 FDA-approved drugs for patients with multiple sclerosis—nine of 10 disease-modifying agents authorized by the agency, plus a drug whose...
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