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A research team led by UC San Francisco scientists has found the genetic signature of enterovirus D68 (EV-D68) in half of California and Colorado children diagnosed with acute flaccid myelitis -- sudden, unexplained muscle weakness and paralysis --... Via Dr. Stefan Gruenwald 
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by Zi-Ye Song, Ryo Yamasaki, Yuji Kawano, Shinya Sato, Katsuhisa Masaki, Satoshi Yoshimura, Dai Matsuse, Hiroyuki Murai, Takuya Matsushita, Jun-ichi Kira Background Fingolimod efficiently reduces multiple sclerosis (MS) relapse by inhibiting...
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Harvard Stem Cell Institute researchers at Massachusetts General Hospital have developed an “imageable” mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain...
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The brain is a privileged organ in the body. So vital to life, the brain is protected from alterations elsewhere in the body by a highly regulated gateway known as the blood-brain barrier, which allows only selected molecules to pass through.
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A monoclonal antibody for Alzheimer's disease reduced amyloid plaques and slowed cognitive decline in a large phase Ib study.
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Abstract Via Krishan Maggon
Krishan Maggon 's curator insight,
April 19, 2015 3:17 AM
doi:10.1016/j.cytogfr.2014.11.005 Highlights
• IFN-β therapy stimulates intra- and inter-cellular networks regulating immune responses. •IFN-β therapy promotes an anti-inflammatory status in MS patients. •IFN-β therapy regulates pathogenic immune cell subsets by modulating bystander responses. •IFN-β effectiveness in MS may rely on both immunomodulatory and anti-viral effects.
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Abnormal levels of anti-collagen type IV IgG antibodies in patients with clinically isolated syndrome correlate to increased risk of multiple sclerosis
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Detection of CNS involvement in childhood ALL by cytomorphology & flow cytometry of the cerebrospinal fluid --> http://t.co/eheQ5CKYiz
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In 2011, Paul Tesar, a professor at Case Western Reserve School of Medicine, worked with collaborators to come up with a method of producing massive ...
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Interleukin-1β protects astrocytes against oxidant-induced injury via an NF-κB-Dependent upregulation of gluta... http://t.co/zdbZnROCv4
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Read about how the antibody level in the cerebrospinal fluid indicates the aggressiveness of multiple sclerosis disease.
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In this exclusive interview, Michael Levy, MD, Department of Neurology at Johns Hopkins Medicine talks about neuromyelitis optica - a rare autoimmune ...
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The importance of co-stimulation in the orchestration of T helper cell ...
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Front Cell Neurosci. 2015 Apr 8;9:132. doi: 10.3389/fncel.2015.00132. eCollection 2015.
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Background: Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is induced by immunization of mice with myelin oligodendrocytic glycoprotein (MOG35-55) injections, and after 9 days, mice develop behavioral signs...
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Extending the dose of natalizumab from four weeks up to eight weeks was shown to be well-tolerated and effective in patients, and resulted in no cases of the potentially fatal side effect progressive multifocal leukoencephalopathy, researchers...
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The purpose of this study was to identify the molecular target of the human monoclonal antibody HIgM12. HIgM12 reverses motor deficits in chronically demyelinated mice, a model of MS. Here we identified polysialic acid (PSA) attached to the Neural Cell Adhesion Molecule (NCAM) as the antigen for HIgM12 by using different NCAM knockout strains and through PSA removal from the NCAM protein core. Antibody binding to CNS tissue and primary cells, antibody-mediated cell adhesion and neurite outgrowth on HIgM12-coated nitrocellulose was detected only in the presence of PSA as assessed by Western blotting, immunoprecipitation, immunocytochemistry and histochemistry. We conclude that HIgM12 mediates it's in vivo and in vitro effects through binding to PSA and has the potential to be an effective therapy for MS and neurodegenerative diseases Via Krishan Maggon
Krishan Maggon 's curator insight,
April 24, 2015 7:35 AM
Watzlawik JO, Kahoud RJ, Ng S, Painter MM, Papke LM, Zoecklein L, Wootla B, Warrington AE, Carey WA, Rodriguez M. Polysialic Acid as an Antigen for Monoclonal Antibody HIgM12 to Treat Multiple Sclerosis and Other Neurodegenerative Disorders.J Neurochem. 2015. doi: 10.1111/jnc.13121. [Epub ahead of print] American Academy of Neurology Annual Meeting 2015 AAN 2015
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Detection of CNS involvement in childhood ALL by cytomorphology & flow cytometry of the cerebrospinal fluid --> http://t.co/eheQ5CKYiz
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In a new study, researchers have made insights into how the blood-brain barrier, or BBB, is maintained, identifying a protein key to the process. Delivering this protein to mice with the rodent equivalent of MS improved their symptoms.
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"This issue of Neurology® Neuroimmunology & Neuroinflammation (N2) incorporates exciting studies on the biology... http://t.co/8WrHHlJEDL
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Cancer Discov. 2015 Apr 15. [Epub ahead of print]
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Tuberous sclerosis (TS), also known as tuberous sclerosis complex or Bourneville disease, is a neurocutaneous disorder (phakomatosis) characterised by development of multiple benign tumours of the embryonic ectoderm, e.g.
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The Monoclonal Antibody Anti-LINGO-1 Is Shown to Repair Damaged Myelin in Acute Optic Neuritis
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Read about the finding that Beta-interferon therapy has no effect on secondary progressive multiple sclerosis onset according to study.
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