NeuroImmunology
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Scooped by Gilbert C FAURE
June 4, 2015 2:29 PM
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Fumaric Acid: an effective drug against psoriasis and multiple sclerosis ? « Globale Dermatologie

From www.globale-dermatologie.com - June 3, 2015 12:58 AM
Article from the JAAD (open access):

Fumaric Acid: an effective drug against psoriasis and multiple sclerosis ? http://t.co/vNtk9IsSQb
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Scooped by Gilbert C FAURE
June 3, 2015 11:11 AM
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Missing link found between brain, immune system -- with major disease implications | Neuroscientist News

Missing link found between brain, immune system -- with major disease implications | Neuroscientist News | NeuroImmunology | Scoop.it
From www.neuroscientistnews.com - June 3, 2015 11:11 AM
Implications profound for neurological diseases from autism to Alzheimer's to multiple sclerosis
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anatomy still fashionable?

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Scooped by Gilbert C FAURE
June 1, 2015 11:10 AM
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A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patie...

A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patie... | NeuroImmunology | Scoop.it
From www.jni-journal.com - May 29, 2015 5:03 AM
A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against... http://t.co/1gZUf8nHob
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Scooped by Gilbert C FAURE
May 29, 2015 8:35 AM
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Economic Evaluation of Bevacizumab for the First-Line Treatment of Newly Diagnosed Glioblastoma Multiforme

Economic Evaluation of Bevacizumab for the First-Line Treatment of Newly Diagnosed Glioblastoma Multiforme | NeuroImmunology | Scoop.it
From jco.ascopubs.org - May 27, 2015 1:00 PM
Economic Evaluation of Bevacizumab for the First-Line Treatment of Newly Diagnosed Glioblastoma Multiforme http://t.co/Yopt3G6Gqv
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Scooped by Gilbert C FAURE
May 28, 2015 3:53 PM
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Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis di... - PubMed - NCBI

Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis di... - PubMed - NCBI | NeuroImmunology | Scoop.it
From www.ncbi.nlm.nih.gov - May 26, 2015 9:38 AM
J Neuroimmunol. 2015 Jun 15;283:64-9. doi: 10.1016/j.jneuroim.2015.04.011. Epub 2015 Apr 25.
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Krishan Maggon 's curator insight, May 28, 2015 11:49 PM
J Neuroimmunol. 2015 Jun 15;283:64-9. doi: 10.1016/j.jneuroim.2015.04.011. Epub 2015 Apr 25.Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis diagnosis.Ferraro D1, Galli V2, Vitetta F3, Simone AM4, Bedin R5, Del Giovane C6, Morselli F7, Filippini MM8, Nichelli PF9, Sola P10.
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Scooped by Gilbert C FAURE
May 27, 2015 2:32 PM
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Transglutaminase 6 Antibodies in the Serum of Patients With Amyotrophic Lateral Sclerosis. - PubMed - NCBI

Transglutaminase 6 Antibodies in the Serum of Patients With Amyotrophic Lateral Sclerosis. - PubMed - NCBI | NeuroImmunology | Scoop.it
From www.ncbi.nlm.nih.gov - May 27, 2015 4:43 AM
JAMA Neurol. 2015 Apr 13. doi: 10.1001/jamaneurol.2015.48. [Epub ahead of print]
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Scooped by Gilbert C FAURE
May 26, 2015 2:53 PM
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CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations against glioma models

CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations against glioma models | NeuroImmunology | Scoop.it
From neuro-oncology.oxfordjournals.org - May 26, 2015 5:51 AM
CD40/CD40L expression correlates w/ survival in patients w/ glioblastoma survival & might affect vaccination response http://t.co/gtuTTKolnL
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Scooped by Gilbert C FAURE
May 17, 2015 4:45 AM
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T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With Glioblastoma - Full Text View - ClinicalTrials.gov

From clinicaltrials.gov - May 13, 2015 10:00 AM
T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With Glioblastoma: Condition:   ... http://t.co/ZbUnLxkTAw
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Scooped by Gilbert C FAURE
May 13, 2015 2:05 PM
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Breaking through the blood-brain barrier

Breaking through the blood-brain barrier | NeuroImmunology | Scoop.it
From www.sciencedaily.com - May 11, 2015 5:27 PM
The bacteria that sneak past the brain's defenses to cause deadly bacterial meningitis are clever adversaries. New research investigates the molecular tricks bacteria use to convince their host that they are harmless and cause disease.
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Scooped by Gilbert C FAURE
May 13, 2015 1:56 PM
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T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With Glioblastoma - Full Text View - ClinicalTrials.gov

From clinicaltrials.gov - May 13, 2015 10:00 AM
T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With Glioblastoma: Condition:   ... http://t.co/ZbUnLxkTAw
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Scooped by Gilbert C FAURE from Multiple sclerosis New Drugs Review
May 13, 2015 1:54 PM
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A Complex Role of Herpes Viruses in the Disease Process of Multiple Sclerosis

A Complex Role of Herpes Viruses in the Disease Process of Multiple Sclerosis | NeuroImmunology | Scoop.it
From journals.plos.org - May 13, 2015 2:24 AM
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS). Neither the antigenic target(s) nor the cell population(s) responsible for CNS tissue destruction in MS have been fully defined.

Via Krishan Maggon
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Krishan Maggon 's curator insight, May 13, 2015 2:24 AM

Citation: Wuest SC, Mexhitaj I, Chai NR, Romm E, Scheffel J, Xu B, et al. (2014) A Complex Role of Herpes Viruses in the Disease Process of Multiple Sclerosis. PLoS ONE 9(8): e105434. doi:10.1371/journal.pone.0105434
H. Fai Poon's curator insight, May 13, 2015 11:31 PM

HPV in MS? wow.... 
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Scooped by Gilbert C FAURE
May 11, 2015 1:51 PM
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Total folate and 5-methyltetrahydrofolate in the cerebrospinal fluid of children: correlation and reference values. - PubMed - NCBI

Total folate and 5-methyltetrahydrofolate in the cerebrospinal fluid of children: correlation and reference values. - PubMed - NCBI | NeuroImmunology | Scoop.it
From www.ncbi.nlm.nih.gov - May 6, 2015 7:06 AM
Clin Chem Lab Med. 2015 May 5. pii: /j/cclm.ahead-of-print/cclm-2015-0208/cclm-2015-0208.xml. doi: 10.1515/cclm-2015-0208. [Epub ahead of print]
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Scooped by Gilbert C FAURE
May 11, 2015 1:49 PM
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Total folate and 5-methyltetrahydrofolate in the cerebrospinal fluid of children: correlation and reference values : Clinical Chemistry and Laboratory Medicine (CCLM)

Total folate and 5-methyltetrahydrofolate in the cerebrospinal fluid of children: correlation and reference values : Clinical Chemistry and Laboratory Medicine (CCLM) | NeuroImmunology | Scoop.it
From www.degruyter.com - May 10, 2015 4:53 PM
Total folate and 5-methyltetrahydrofolate in the cerebrospinal fluid of children: correlation and reference values
http://t.co/PspHK9MG0Q
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Scooped by Gilbert C FAURE
June 4, 2015 11:12 AM
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Endogenous opioid inhibition of proliferation of T and B cell subpopulations in response to immunization for experimental autoimmune encephalomyelitis

From www.biomedcentral.com - April 24, 2015 8:00 AM
Background: Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is induced by immunization of mice with myelin oligodendrocytic glycoprotein (MOG35-55) injections, and after 9 days, mice develop behavioral signs...
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Scooped by Gilbert C FAURE
June 3, 2015 8:42 AM
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Th17/RORgt transgenic EAE model for multiple sclerosis

From www.youtube.com - May 30, 2015 11:14 PM
Journal of Neuroimmunology manuscript, "RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis." is explained in 3:38 ...
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Scooped by Gilbert C FAURE
May 29, 2015 8:35 AM
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World MS Day 2015: Facts and figures about neurological condition multiple sclerosis

World MS Day 2015: Facts and figures about neurological condition multiple sclerosis | NeuroImmunology | Scoop.it
From www.ibtimes.co.uk - May 27, 2015 8:08 AM
World MS Day on 27 May is aimed at raising awareness of the autoimmune condition multiple sclerosis
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Scooped by Gilbert C FAURE
May 29, 2015 8:34 AM
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Relation between plasmatic and cerebrospinal fluid oxidative stress biomarkers and intrathecal Ig synthesis in Multiple Sclerosis patients. - PubMed - NCBI

Relation between plasmatic and cerebrospinal fluid oxidative stress biomarkers and intrathecal Ig synthesis in Multiple Sclerosis patients. - PubMed - NCBI | NeuroImmunology | Scoop.it
From www.ncbi.nlm.nih.gov - May 26, 2015 10:09 AM
J Neuroimmunol. 2015 Jun 15;283:39-42. doi: 10.1016/j.jneuroim.2015.04.010. Epub 2015 Apr 28.
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Scooped by Gilbert C FAURE
May 27, 2015 3:06 PM
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TGFβ1 exacerbates blood–brain barrier permeability in a mouse model of ... - Nature.com

From news.google.com - May 25, 2015 10:37 AM
TGFβ1 exacerbates blood–brain barrier permeability in a mouse model of ...
Nature.com
Furthermore, circulating transforming growth factor β1 (TGFβ1) is increased following liver damage and may promote endothelial cell permeability.
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Scooped by Gilbert C FAURE
May 26, 2015 2:57 PM
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An Animated Word Cloud of MS Clinical Trials | Multiple Sclerosis Discovery Forum

An Animated Word Cloud of MS Clinical Trials | Multiple Sclerosis Discovery Forum | NeuroImmunology | Scoop.it
From www.msdiscovery.org - May 23, 2015 4:17 AM
An Animated Word Cloud of MS Clinical Trials | Multiple Sclerosis Discovery Forum http://t.co/rda3qasYix
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Scooped by Gilbert C FAURE from Multiple sclerosis New Drugs Review
May 25, 2015 12:28 PM
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Daclizumab reverses intrathecal immune cell abnormalities in multiple sclerosis - Lin - 2015 - Annals of Clinical and Translational Neurology - Wiley Online Library

Daclizumab reverses intrathecal immune cell abnormalities in multiple sclerosis - Lin - 2015 - Annals of Clinical and Translational Neurology - Wiley Online Library | NeuroImmunology | Scoop.it
From onlinelibrary.wiley.com - May 24, 2015 10:47 AM
AbstractOBJECTIVE:

Novel treatments such as natalizumab and fingolimod achieve their therapeutic efficacy in multiple sclerosis (MS) by blocking access of subsets of immune cells into the central nervous system, thus creating nonphysiological intrathecal immunity. In contrast, daclizumab, a humanized monoclonal antibody against the alpha chain of the IL-2 receptor, has a unique mechanism of action with multiple direct effects on innate immunity. As cellular intrathecal abnormalities corresponding to MS have been well defined, we asked how daclizumab therapy affects these immunological hallmarks of the MS disease process.

METHODS:

Nineteen subpopulations of immune cells were assessed in a blinded fashion in the blood and 50-fold concentrated cerebrospinal fluid (CSF) cell pellet in 32 patients with untreated relapsing-remitting MS (RRMS), 22 daclizumab-treated RRMS patients, and 11 healthy donors (HDs) using 12-color flow cytometry.

RESULTS:

Long-term daclizumab therapy normalized all immunophenotyping abnormalities differentiating untreated RRMS patients from HDs. Specifically, strong enrichment of adaptive immune cells (CD4+ and CD8+ T cells and B cells) in the CSF was reversed. Similarly, daclizumab controlled MS-related increases in the innate lymphoid cells (ILCs) and lymphoid tissue inducer cells in the blood and CSF, and reverted the diminished proportion of intrathecal monocytes. The only marker that distinguished daclizumab-treated MS patients from HDs was the expansion of immunoregulatory CD56(bright) NK cells.

INTERPRETATION:

Normalization of immunological abnormalities associated with MS by long-term daclizumab therapy suggests that this drug's effects on ILCs, NK cells, and dendritic cell-mediated antigen presentation to CD4+ and CD8+ T cells are critical in regulating the MS disease process.


Via Krishan Maggon
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Krishan Maggon 's curator insight, May 24, 2015 10:52 AM
Ann Clin Transl Neurol. 2015 May;2(5):445-55. doi: 10.1002/acn3.181. Epub 2015 Apr 7.Daclizumab reverses intrathecal immune cell abnormalities in multiple sclerosis.Lin YC1, Winokur P1, Blake A1, Wu T2, Romm E1, Bielekova B3.
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Scooped by Gilbert C FAURE
May 15, 2015 9:32 AM
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Targeting epidermal fatty acid binding protein for treatment of experimental autoimmune encephalomyelitis

From www.biomedcentral.com - May 12, 2015 8:00 AM
Background:
Multiple sclerosis (MS) is an autoimmune disease in which dysregulated immune cells attack myelin in the central nervous system (CNS), leading to irreversible neuronal degeneration.
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Scooped by Gilbert C FAURE
May 13, 2015 1:57 PM
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Cerebrospinal Fluid And Flow Cytometry | update: 12.05.2015

From facetopics.com - May 13, 2015 5:34 AM
#facetopics_it R: cerebrospinal fluid and flow cytometry http://t.co/W2FGPBcT8z
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Scooped by Gilbert C FAURE
May 13, 2015 1:55 PM
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National Centre for Neuroimmunology and... - May 12th - International ME/CFS & FM Awareness Day | Facebook

Post by may12th.awareness.
From www.facebook.com - May 12, 2015 4:06 AM
National Centre for Neuroimmunology and Emerging Diseases at Griffiths University in Australia
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Scooped by Gilbert C FAURE
May 12, 2015 3:47 PM
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Treatment with Vitamin D/MOG Association Suppresses Experimental Autoimmune Encephalomyelitis

Treatment with Vitamin D/MOG Association Suppresses Experimental Autoimmune Encephalomyelitis | NeuroImmunology | Scoop.it
From journals.plos.org - May 12, 2015 3:19 PM
by Fernanda Chiuso-Minicucci, Larissa Lumi Watanabe Ishikawa, Luiza Ayumi Nishiyama Mimura, Thais Fernanda de Campos Fraga-Silva, Thais Graziela Donegá França, Sofia Fernanda Gonçalves Zorzella-Pezavento, Camila Marques, Maura Rosane Valerio Ikoma,...
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Scooped by Gilbert C FAURE
May 11, 2015 1:50 PM
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Cerebrospinal fluid tau proteins in status epilepticus. - PubMed - NCBI

Cerebrospinal fluid tau proteins in status epilepticus. - PubMed - NCBI | NeuroImmunology | Scoop.it
From www.ncbi.nlm.nih.gov - May 11, 2015 6:15 AM
Epilepsy Behav. 2015 May 6. pii: S1525-5050(15)00199-7. doi: 10.1016/j.yebeh.2015.04.030. [Epub ahead of print]
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