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The function of pejvakin, a molecule that plays a vital role in the hearing system, has been recently discovered by researcherse. 
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Nature.com B cells Resetting the scene Nature.com T cells and myeloid cells have a central role in the immunopathology of multiple sclerosis, but it is unclear how B cell depletion therapy efficiently controls the inflammatory response in...
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1:45 – 2:15 Fernando de Castro (Instituto Cajal) “Functional heterogeneity of oligodendrocyte precursor cells: From CNS development towards remyelination in ...
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Roche hits multiple sclerosis landmarks
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Highlights •EAE-induced mice display BBB permeability to therapeutically dosed antibodies•Intact BBB in multiple mouse models of AD restricts passive antibody uptake in brain•Brain infarcts and TfR levels are similar in human AD and control samples•BBB-crossing strategies are necessary to enhance delivery of antibody therapeutics
Summary
The blood-brain barrier (BBB) limits brain uptake of therapeutic antibodies. It is believed that the BBB is disrupted in Alzheimer’s disease (AD), potentially increasing drug permeability de facto. Here we compared active versus passive brain uptake of systemically dosed antibodies (anti-transferrin receptor [TfR] bispecific versus control antibody) in mouse models of AD. We first confirmed BBB disruption in a mouse model of multiple sclerosis as a positive control. Importantly, we found that BBB permeability was vastly spared in mouse models of AD, including PS2-APP, Tau transgenics, and APOE4 knockin mice. Brain levels of TfR in mouse models or in human cases of AD resembled controls, suggesting target engagement of TfR bispecific is not limited. Furthermore, infarcts from human AD brain showed similar occurrences compared to age-matched controls. These results question the widely held view that the BBB is largely disrupted in AD, raising concern about assumptions of drug permeability in disease. Via Krishan Maggon
Krishan Maggon 's curator insight,
October 26, 2015 2:38 PM
Neuron
Volume 88, Issue 2, p289–297, 21 October 2015 Report Switch to Standard View Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies Nga Bien-Ly, C. Andrew Boswell, Surinder Jeet, Thomas G. Beach, Kwame Hoyte, Wilman Luk, Vera Shihadeh, Sheila Ulufatu Oded Foreman, Yanmei Lu, Jason DeVoss , Marcel van der Brug, Ryan J. Watts
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Scientific Reports is an online, open access journal from the publishers of Nature. The 2014 Impact Factor for Scientific Reports is 5.578.
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Cerebrospinal fluid angiotensin-converti
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October 15, 2015 2:35 PM
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Cerebrospinal fluid white cell count: discriminatory or otherwise for enteroviral meningitis in infants and young ... http://t.co/avPT02mI7d
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Gilbert C FAURE
October 15, 2015 7:40 AM
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by Sofie Stalmans, Nathalie Bracke, Evelien Wynendaele, Bert Gevaert, Kathelijne Peremans, Christian Burvenich, Ingeborgh Polis, Bart De Spiegeleer Cell-penetrating peptides (CPPs) are a group of peptides, which have the ability to cross cell...
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Gilbert C FAURE
October 13, 2015 1:08 PM
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Results of clinical trials show promise in reducing the progression of the disease, researchers say. New drug could be on the market by 2017.
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October 13, 2015 1:06 PM
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Case series of choroid plexus papilloma in children at uncommon locations and review of the literature http://t.co/vXRXzgTRbM
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Gilbert C FAURE
October 12, 2015 10:05 AM
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Front Hum Neurosci. 2015 Sep 10;9:476. doi: 10.3389/fnhum.2015.00476. eCollection 2015.
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Gilbert C FAURE
October 12, 2015 7:05 AM
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The FDA recently allowed marketing of the first cerebrospinal fluid nucleic acid-based panel for concurrent detection of multiple pathogens responsible for central nervous system infections.The FilmArray Meningitis/Encephalitis Panel, manufactured...
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Gilbert C FAURE
November 5, 2015 3:00 PM
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by Evelien Wynendaele, Frederick Verbeke, Sofie Stalmans, Bert Gevaert, Yorick Janssens, Christophe Van De Wiele, Kathelijne Peremans, Christian Burvenich, Bart De Spiegeleer Bacteria communicate with each other by the use of signaling molecules, a...
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November 3, 2015 3:33 AM
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Multiple sclerosis, a debilitating neurological disease, is triggered by self-reactive T cells that successfully infiltrate the brain and spinal cord where they launch an aggressive autoimmune attack against myelin, the fatty substance that...
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November 2, 2015 12:58 PM
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Mutations in the TLR3 signaling pathway and beyond in adult patients with ...
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October 30, 2015 4:33 PM
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Complement 3 and metabolic syndrome induced by clozapine: a cross-sectional ...
Nature.com
A prominent part of inflammatory reactions is the activation of the complement system.
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October 25, 2015 7:24 AM
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The inflammatory hypothesis of depression is one of the main theories that endeavors to explain and describe the underlying biological mechanisms of depression and suicide.
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October 25, 2015 6:48 AM
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RT @TCGAupdates: Neat Review: MicroRNA as biomarkers in #Glioblastoma http://t.co/S74HXcOKof
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from MRC research in the news
October 16, 2015 5:46 AM
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It may be possible to prevent schizophrenia by calming down the brain's immune system, say MRC scientists.
Dr Oliver Howes, the head of the psychiatric imaging group at the MRC Clinical Sciences Centre, said: "This is a real step forward in understanding. For the first time we have evidence that there is over-activity even before full onset of the illness. If we could reduce activity [before full-blown illness] then we might be able to prevent the illness - that needs to be tested, but is one key implication [of the research]."
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October 15, 2015 2:16 PM
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RT @GreenJournal: Name a brain protein, and an autoantibody shall be found! http://t.co/E6FrAX9LJH #Neurology
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Gilbert C FAURE
October 15, 2015 5:12 AM
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Information on the range of services at Charité - Universtätsmedizin Berlin for patients, physicians, students and scientists
Macrophages centered
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Gilbert C FAURE
October 13, 2015 1:06 PM
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Dispatch Tribunal
New Roche's Multiple Sclerosis Drug Shows Great Promise
Pioneer News
Pharmaceutical company Roche has a much-hyped multiple sclerosis drug called ocrelizumab which has, apparently lived up to the hype.
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Gilbert C FAURE
October 12, 2015 1:10 PM
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A new study from the Gladstone Institutes shows that a single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis (MS).
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Gilbert C FAURE
October 12, 2015 7:06 AM
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Nature World Report
Roche's new multiple sclerosis drug could revolutionize treatment
Nature World Report
Currently, the most effective treatment for MS is a drug called Rebif.
