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PLoS Pathog. 2014 Dec 4;10(12):e1004506. doi: 10.1371/journal.ppat.1004506. eCollection 2014. 
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Immunity. 2014 Nov 20;41(5):776-788. doi: 10.1016/j.immuni.2014.10.007. Epub 2014 Nov 6.
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Gilbert C FAURE's insight:
from FcRN to epithelial cells
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FEBS Lett. 2014 May 27. pii: S0014-5793(14)00421-9. doi: 10.1016/j.febslet.2014.05.034. [Epub ahead of print] REVIEW
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After spending more than a decade decoding breast milk’s important health-promoting constituents, a team of researchers in the Foods for Health
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The mucosal inflammatory response to non-typhoidal Salmonella in the intestine ...
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Fate PPAR-titioning: PPAR-γ 'instructs' alveolar macrophage development
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Microbiologists say they have what may be the first strong evidence that the natural presence of viruses in the gut — or what they call the ‘virome’ — plays a health-maintenance and infection-fighting role similar to that of the intestinal bacteria that dwell there and make up the “microbiome.”
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Mononuclear phagocytes of the intestine, the skin, and the lung Scott 2014 Immunological Reviews Wiley Online http://t.co/2I1JgU0NCi
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Mucosal immunology Sick of the flu
Gilbert C FAURE's insight:
This study provides a mechanism for such symptoms by showing that CD4 T cells from the respiratory mucosa are recruited to the intestinal mucosa during influenza virus infection, where they induce dysbiosis that stimulates T helper 17 (TH17) cell-mediated inte…
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CEACAM1 regulates TIM-3-mediated tolerance and exhaustion Nature.com T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell...
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Genocea Kicks Off Phase 2 Trial For Pneumococcus Vaccine
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by Lars Råberg
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by Raul Ramos Furtado Dias, Eulógio Carlos Queiroz de Carvalho, Carla Cristina da Silva Leite, Roberto Carlos Tedesco, Katia da Silva Calabrese, Antonio Carlos Silva, Renato Augusto DaMatta, Maria de Fatima Sarro-Silva Toxoplasmosis is a worldwide...
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Scientists have taken an important step toward a new class of antibiotics aimed at stopping lung infections.
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by Patricia L. Hibberd, Lauren Kleimola, Anne-Maria Fiorino, Christine Botelho, Miriam Haverkamp, Irina Andreyeva, Debra Poutsiaka, Claire Fraser, Gloria Solano-Aguilar, David R.
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Diarrhoea caused by Escherichia coli is an important cause of infant morbidity and mortality in developing countries.
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Targeting α 4 β 7 integrin reduces mucosal transmission of simian ...
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(Phys.org) —Researchers at the University of New Mexico recently discovered an olfactory immune system in fish previously thought to be associated with terrestrial vertebrates only.
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The messenger between worlds: the regulation of innate and adaptive type-2 immunity by innate lymphoid cells: ... http://t.co/94LRN5TAm6
Gilbert C FAURE's curator insight,
November 26, 2014 3:48 AM
Abstract
Although type-2 immune responses evolved primarily to defend against extracellular helminths, in part through the co-opting of tissue repair and remodelling mechanisms, it is often inappropriately directed towards relatively innocuous allergens resulting in conditions including asthma, allergic rhinitis, food allergy, and atopic dermatitis. The recent discovery of group 2 innate lymphoid cells (ILC2) has increased our understanding of the initiation of these responses and the roles played by CD4+ T helper (TH) 2 cells in their modulation. This review focuses on the important messenger role of ILC2 in translating epithelial-derived alarmins into downstream adaptive type-2 responses via dendritic cells and T cells, with special emphasis on their roles in allergic disease.
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As many as 80 million bacteria are transferred during a 10 second kiss, according to new research. The study also found that partners who kiss each other at least nine times a day share similar communities of oral bacteria.
Gilbert C FAURE's insight:
quantifying promiscuity
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Gamma delta T cells represent a major T cell population in epithelial tissues, such as skin, intestine, and lung, where they function in maintenance of the epithelium and provide a crucial first li...
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The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus...
Gilbert C FAURE's insight:
Abstract Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search for the expression of serum antibodies against GnRH1 with an improved enzyme-linked immune sorbent assay (ELISA), and antibodies against progonadoliberin-2, GnRH2, GnRH receptor, LH, and LH receptor with newly developed ELISAs, in patients with gastrointestinal dysfunction or diabetes mellitus. Healthy blood donors served as controls. Medical records were scrutinized. Our conclusion was that IgM antibodies against GnRH1, progonadoliberin-2, and/or GnRH receptors were more prevalent in patients with functional gastrointestinal disorders, gastrointestinal dysmotility, and/or diabetes mellitus, whereas IgG antibodies against these peptides, and LH- and LH receptor antibodies, were expressed in the same magnitude as in controls.
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Which statement is true?
A. 60% of all households without toilets in the world are in India.
Chris Costa's curator insight,
November 15, 2015 2:18 PM
I was unpleasantly surprised to learn that all these statements are indeed true. Reading about the struggles India has endured with the lack of indoor plumbing many of its people must endure made me think of a previous article I had read about the "Two Mexico's." Rapid development in certain areas for certain people has revolutionized the standard of living for some, but the persistence of corruption has lead to economic lag for many of the people of both nations, meaning significant portions of the population are being left behind during this period of development. The sanitation and plumbing systems of inca are woefully inadequate for a country of over a billion people, subtracting from the leaps that have been made in other areas. The dangers faced by women as a result of the lack of indoor plumbing was a surprise, although it does make sense. Millions of Indian women have to resort to walking to communal bathrooms, oftentimes at night on solitary trips, which leaves them vulnerable to the kids of sexual assault that have plagued Indian media. I hope for the sake of the Indian people that improvements in the rates of indoor plumbing in the country continue to be made. 
Matt Ramsdell's curator insight,
December 14, 2015 2:46 PM
One thing about this issue is the fact that most of the people living in the area dont have the proper sanitation. Many of the issues that they face are a lack of government and funding and jobs. However the issue in India is the worst within the world. China has a huge lack of sanitation but in India the situation is much worse. 
Adam Deneault's curator insight,
December 14, 2015 6:38 PM
Something like this just disgusts me, first off there are more cell phones in this country than toilets... how does a government allow that to happen? Clearly, the answer is, they must not care because there is lack of governmental help. These people do not have toilets in there houses, they have to go down the street to a public restroom where thousands of people go a day both sick and healthy, so there are probably terrible sicknesses running rampant. Hopefully for them, they do not get a life threatening disease that will kill off the population.
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National Hog Farmer
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