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Scooped by
Gilbert C FAURE
September 2, 2015 8:26 AM
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by Maksudul Alam, Xinwei Deng, Casandra Philipson, Josep Bassaganya-Riera, Keith Bisset, Adria Carbo, Stephen Eubank, Raquel Hontecillas, Stefan Hoops, Yongguo Mei, Vida Abedi, Madhav Marathe Agent-based models (ABM) are widely used to study immune...
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Scooped by
Gilbert C FAURE
September 2, 2015 4:53 AM
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Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically… http://t.co/Oz8NFkbwxM
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Scooped by
Gilbert C FAURE
September 1, 2015 8:23 AM
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Researchers have provided the first proof of concept data showing that a monoclonal antibody can neutralize human norovirus. This research could one day lead to effective therapies against the virus.
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Rescooped by
Gilbert C FAURE
from Immunology
September 1, 2015 3:20 AM
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Highlights •Treg cells serve as a major early source of amphiregulin during influenza infection•Amphiregulin expression in Treg cells is dispensable for their suppressor function•Amphiregulin deficiency in Treg cells results in severe damage of infected lungs•Treg cell production of amphiregulin is IL-18/IL-33 dependent but TCR independent Summary Regulatory T (Treg) cells suppress immune responses to a broad range of non-microbial and microbial antigens and indirectly limit immune inflammation-inflicted tissue damage by employing multiple mechanisms of suppression. Here, we demonstrate that selective Treg cell deficiency in amphiregulin leads to severe acute lung damage and decreased blood oxygen concentration during influenza virus infection without any measureable alterations in Treg cell suppressor function, antiviral immune responses, or viral load. This tissue repair modality is mobilized in Treg cells in response to inflammatory mediator IL-18 or alarmin IL-33, but not by TCR signaling that is required for suppressor function. These results suggest that, during infectious lung injury, Treg cells have a major direct and non-redundant role in tissue repair and maintenance—distinct from their role in suppression of immune responses and inflammation—and that these two essential Treg cell functions are invoked by separable cues.
Via Krishan Maggon , Gilbert C FAURE
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Scooped by
Gilbert C FAURE
August 31, 2015 1:31 PM
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Neurogastroenterol Motil. 2015 Aug 24. doi: 10.1111/nmo.12658. [Epub ahead of print]
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Scooped by
Gilbert C FAURE
August 31, 2015 1:27 PM
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People with IgA antibodies to tissue transglutaminase (anti-tTg) likely have a higher risk for celiac disease.
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Scooped by
Gilbert C FAURE
August 31, 2015 1:25 PM
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Eur J Immunol. 2014 Feb;44(2):440-9. Research Support, Non-U.S. Gov't
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Scooped by
Gilbert C FAURE
August 31, 2015 9:07 AM
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OpenBiome turns poop from extremely healthy people into a life-saving treatment for C. difficile. Highly select donors are paid $40 for each stool they donate.
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Scooped by
Gilbert C FAURE
August 31, 2015 8:40 AM
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Int J Ophthalmol. 2015 Aug 18;8(4):690-6. doi: 10.3980/j.issn.2222-3959.2015.04.09. eCollection 2015.
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Rescooped by
Gilbert C FAURE
from Immunology
August 31, 2015 5:21 AM
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Ohnmacht et al. (2) and Sefik et al. (3), respectively, report the development and function of a subpopulation of Treg cells found primarily in the large intestine, and characterized by expression of the nuclear hormone receptor retinoic acid receptor-related orphan receptor γt (RORγt). This is surprising because RORγt classically promotes the differentiation of T helper 17 (TH17) cells, a population associated with tissue inflammation in many inflammatory diseases (4). Both studies show that microbiota-derived signals induce the expression of RORγt in Treg cells that control intestinal inflammation (see the figure). These findings highlight the diversity of colonic Treg cells, their complex transcriptional programs, and their important role in the intestine.
Via Marcelo de Carvalho Bittencourt
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Scooped by
Gilbert C FAURE
August 28, 2015 7:27 AM
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Diets rich in fish oil versus diets rich in lard (e.g., bacon) produce very different bacteria in the guts of mice, reports a new study. The researchers transferred these microbes into other mice to see how they affected health.
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Scooped by
Gilbert C FAURE
August 28, 2015 5:58 AM
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by Tanja Burnik Papler, Eda Vrtacnik Bokal, Ales Maver, Andreja Natasa Kopitar, Luca Lovrečić Specific gene expression in oocytes and its surrounding cumulus (CC) and granulosa (GC) cells is needed for successful folliculogenesis and oocyte...
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Rescooped by
Gilbert C FAURE
from Immunology and Biotherapies
August 28, 2015 5:13 AM
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This review focuses on recent advances in understanding the mechanisms that coordinate the collaboration between ILCs and T cells under homeostatic and inflammatory conditions. We also discuss the potential roles of T cells and other immune cells to regulate ILC functions and to maintain homeostasis in mucosal tissues.
Via Marcelo de Carvalho Bittencourt
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Scooped by
Gilbert C FAURE
September 2, 2015 5:00 AM
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How Should #FDA Regulate #Fecal #Microbiota #Transplants/#FMT? @RESachs in @MITMicrobiome w/@caredelstein @OpenBiome http://t.co/3Ffbx3gO1R
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Rescooped by
Gilbert C FAURE
from Immunology
September 2, 2015 4:52 AM
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by Diana Fatykhova, Anne Rabes, Christoph Machnik, Kunchur Guruprasad, Florence Pache, Johanna Berg, Mario Toennies, Torsten T. Bauer, Paul Schneider, Maria Schimek, Stephan Eggeling, Timothy J. Mitchell, Andrea M.
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Scooped by
Gilbert C FAURE
September 1, 2015 4:37 AM
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Crohn's disease and ulcerative colitis are chronic autoimmune diseases that affect as many as 1.6 million Americans. Patients with Inflammatory Bowel Disease (IBD) have immune systems that attack t...
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Scooped by
Gilbert C FAURE
August 31, 2015 1:46 PM
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RT @britsocimm: Immune #homeostasis, dysbiosis and therapeutic modulation of the gut #microbiota http://t.co/9qSRdFyu5E #immunology http://…
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Scooped by
Gilbert C FAURE
August 31, 2015 1:30 PM
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Background:
Endometriosis is defined as the presence of endometrial glands and stroma at ectopic locations. Although the prevalence of endometriosis is as high as 35 %–50 %, its pathogenesis remains controversial.
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Scooped by
Gilbert C FAURE
August 31, 2015 1:26 PM
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Outbreak News Today Early results released on Vaxart's Oral H1N1 influenza vaccine Outbreak News Today Vaxart's H1N1 influenza tablet vaccine demonstrated protective immunity based on Hemagglutinin Inhibition Assay (HAI) with HAI titer increases...
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Scooped by
Gilbert C FAURE
August 31, 2015 10:46 AM
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by James D. Lord, Donna M. Shows, Janice Chen, Richard C. Thirlby
Background FOXP3+ regulatory T cells (Tregs) are critical for preventing intestinal inflammation.
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Scooped by
Gilbert C FAURE
August 31, 2015 8:57 AM
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A protein known as sperm lysozyme-like protein 1 (SLLP1) works like a harpoon allowing the sperm cell to latch onto and fertilize the egg.
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Scooped by
Gilbert C FAURE
August 31, 2015 8:38 AM
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In experiments with mouse tissue, researchers have discovered that the adaptive immune system, generally associated with fighting infections, plays an active role in guiding the normal development of mammary glands, the only organs -- in female...
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Scooped by
Gilbert C FAURE
August 31, 2015 2:29 AM
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What would modern life be like without the humble toilet? Actually, we’d rather not think about that.
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Scooped by
Gilbert C FAURE
August 28, 2015 7:25 AM
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World J Microbiol Biotechnol. 2015 Jan;31(1):11-21. doi: 10.1007/s11274-014-1760-7. Epub 2014 Oct 18. Research Support, Non-U.S. Gov't
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Scooped by
Gilbert C FAURE
August 28, 2015 5:58 AM
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by Kitti Torrungruang, Supawadee Jitpakdeebordin, Orawan Charatkulangkun, Yingampa Gleebbua
Periodontitis is a polymicrobial infection of tooth-supporting tissues.
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