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Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues.
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This study evaluated the associations between clinical, microbiological, and antibody activity manifestations of periodontitis in 123 adult rural Chinese subjects with no dental intervention.
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Treatment and prevention of life-threatening infections could be improved by research from the University of Edinburgh that reveals how bacteria are kept in check.
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Mol Immunol. 2015 Nov;68(1):28-30. doi: 10.1016/j.molimm.2015.07.030. Research Support, Non-U.S. Gov't; Review
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Mucosal Immunol. 2015 May;8(3):491-504. doi: 10.1038/mi.2014.82. Epub 2014 Oct 1. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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A breakthrough in basic research and the first comprehensive study on the secretory activity of the human intestine: over a period of eight years, medical researchers have examined more than 2,200 specimens from around 450 patients with bowel...
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Super-shedder cattle are a major disseminator of E . coli O157:H7 into the environment, and the terminal rectum has been proposed as the primary E . coli O157:H7 colonization site.
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End-stage liver disease or liver cirrhosis is the tenth leading cause of death in the United States, and approximately half of these cases are related to alcohol consumption. There's no refuting that alcohol itself harms the liver, but new research in mice and humans published Feb. 10 in Cell Host & Microbe reveals that chronic drinking also promotes the growth of gut bacteria that can travel to the liver and exacerbate liver disease.
Gilbert C FAURE's insight:
REG3b, REG3G
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Th17 cells and Foxp3 + regulatory T cells (Tregs) are thought to promote and suppress inflammatory responses, respectively. However, whether they counteract each other or synergize in regulating immune reactions remains controversial.
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Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection in infants, causing significant morbidity and mortality. No vaccine or specific, effective treatment is currently available.
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Live attenuated vaccines such as SIV with a deleted nef gene have provided the most robust protection against subsequent vaginal challenge with wild-type (WT) SIV in the SIV–rhesus macaque model of HIV-1 transmission to women.
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It is not clear whether gut microbiota can induce systemic responses. Nunez and colleagues find that the gut microbiota induces the generation of IgG antibodies under homeostatic conditions.
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During gestation, a mother's microbiome shapes the immune system of her offspring, a new study in mice suggests.
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![Mucosal Immunology - Intestinal CD103+CD11b- dendritic cells restrain colitis via IFN-[gamma]-induced anti-inflammatory response in epithelial cells | Mucosal Immunity | Scoop.it](https://img.scoop.it/uR1K8Vl9Z3rUdibztVv6Izl72eJkfbmt4t8yenImKBVvK0kTmF0xjctABnaLJIm9)
Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues.
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We employed an RNA-guided CRISPR/Cas9 DNA editing system to precisely remove the entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated HIV-1 proviral DNA copies from latently infected human CD4+ T-cells. Via Kenzibit
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Video Journal Club describing the Review article in Nature Review
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The concurrent increases in global population and sexually transmitted infection (STI) demand a search for agents with dual spermicidal and microbicidal properties for topical vaginal application.
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This article reviews the current progress being made in novel drug and vaccine development and delves into alternative medical, surgical, and homeopathic strategies that may be promising adjunctive treatments for the difficult-to-treat rhinitis...
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Background Removal of the appendix might induce physiological changes in the gastrointestinal tract, and subsequently play a role in carcinogenesis.
Gilbert C FAURE's insight:
a real epidemiological study!
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Failure to tolerate gut microbiota transforms immunodeficiency into immunopathology
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Microbiota-specific serum IgG protects against systemic bacterial dissemination during leaky gut
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Complement is present mainly in blood. However, following mechanical damage or inflammation, serous exudates enter the mucosal surfaces.
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Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1), Th17 and regulatory T-cell (Treg) responses, throughout life.
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An intronic variant at the complement factor H (CFH) gene on chromosome 1q32 (rs6677604) associates with risk of IgA nephropathy (IgAN), but the association signal has not been uniformly replicated in Han Chinese populations.
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