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Researchers in this study identified correlations between phenotypes and inflammatory endotypes in patients with chronic rhinosinusitis which may aid in a more accurate description of distinct clusters of chronic rhinosinusitis, according to recent...
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Demystifying Medicine 2016: The Oral Microbiome Meets Cell Biology and Periodontal Disease Air date: Tuesday, March 29, 2016, 4:00:00 PM Category: ...
Gilbert C FAURE's insight:
NIH
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Specific CD4+ T cells keeping our gut bugs at bay. #autoimmunity #HIVAIDS https://t.co/jkraNMdROL
Gilbert C FAURE's insight:
open?
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X-ray crystallography studies of a full-size form of human secretory component (SC) done in Pamela Bjorkman’s laboratory at Caltech reveal ne
Gilbert C FAURE's insight:
new structural insights into how SC binds to dimeric IgA. The 5 Ig domains of free SC assemble into a compact triangular structure with significant interfaces between domain 1 (D1) and both D4 and D5. When SC begins to bind to a molecule of dimeric IgA or polymeric IgM, the D1 interfaces with D4 and D5 are disrupted allowing the triangular SC structure to open up into an elongated confirmation that exposes buried D1 residues that subsequently contribute to stabilizing ligand binding
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Secretory IgA in the Coordination of Establishment and Maintenance of the Microbiota https://t.co/763ntzLSKb
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J Exp Med. 2016 Apr 4;213(4):517-34. doi: 10.1084/jem.20160062. Epub 2016 Mar 21.
Gilbert C FAURE's insight:
Conventional dendritic cells (cDCs) play an essential role in host immunity by initiating adaptive T cell responses and by serving as innate immune sensors. Although both innate and adaptive functions of cDCs are well documented, their relative importance in maintaining immune homeostasis is poorly understood. To examine the significance of cDC-initiated adaptive immunity in maintaining homeostasis, independent of their innate activities, we generated a cDC-specific Cre mouse and crossed it to a floxed MHC class II (MHCII) mouse. Absence of MHCII on cDCs resulted in chronic intestinal inflammation that was alleviated by antibiotic treatment and entirely averted under germ-free conditions. Uncoupling innate and adaptive functions of cDCs revealed that innate immune functions of cDCs are insufficient to maintain homeostasis and antigen presentation by cDCs is essential for a mutualistic relationship between the host and intestinal bacteria.
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PLoS One. 2015 May 28;10(5):e0126463. doi: 10.1371/journal.pone.0126463. eCollection 2015. Clinical Trial; Research Support, Non-U.S. Gov't
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Am J Reprod Immunol. 2015 Aug;74(2):110-5. doi: 10.1111/aji.12380. Epub 2015 Mar 27. Research Support, Non-U.S. Gov't
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Helicobacter pylori (H. pylori) is a common pathogenic bacterium in the stomach that infects almost half of the population worldwide and is closely related to gastric diseases and some extragastric diseases, including iron-deficiency anemia and...
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Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues.
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Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues.
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The ISME Journal: Multidisciplinary Journal of Microbial Ecology is the official Journal of the International Society for Microbial Ecology, publishing high-quality, original research papers, short communications, commentary articles and reviews in...
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RT @CellCellPress: Good things happen when #immunotherapy meets the #microbiome! Zitvogel & al FREE treat https://t.co/8uJhzjlKsk @AACR htt…
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Oral vaccination strategies are of interest to prevent transmission of Lyme disease as they can be used to deliver vaccines to humans, pets, and to natural wildlife reservoir hosts of Borrelia burgdorferi .
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RT @britsocimm: "The intestinal microbiome in type 1 #diabetes" #T1D #worldhealthday #unworldhealthday https://t.co/ZQQG9e65Ig https://t.co… | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights...
Via Remi Creusot
Remi Creusot's curator insight,
April 7, 2016 12:05 PM
Jessica Dunne from JDRF and members of the T1D microbiome consortium have put together a nice review on the progress made so far in understanding the interplay between commensal microbes and Type 1 diabetes.
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Cell Mol Immunol. 2016 Mar 28. doi: 10.1038/cmi.2015.105. [Epub ahead of print] REVIEW
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Swiss Med Wkly. 2016 Apr 5;146:w14293. doi: 10.4414/smw.2016.14293. eCollection 2016.
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Background Accumulating evidence shows that Helicobacter pylori protects against some metabolic and immunological diseases in which the development of these diseases coincide with temporal or permanent dysbiosis.
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Microbial colonization of the infant gastrointestinal tract (GIT) begins at birth, is shaped by the maternal microbiota, and is profoundly altered by antibiotic treatment.
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The UCLA Department of Pathology and Laboratory Medicine presents: The 2016 Harrison and Lya Cordova Latta Lecture James Versalovic, M.D., Ph.
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Neovascular age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV).
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Colonic epithelial cells are covered by thick inner and outer mucus layers1, 2. The inner mucus layer is free of commensal microbiota, which contributes to the maintenance of gut homeostasis3, 4, 5, 6. In the small intestine, molecules critical for prevention of bacterial invasion into epithelia such as Paneth-cell-derived anti-microbial peptides and regenerating islet-derived 3 (RegIII) family proteins have been identified7, 8, 9, 10, 11. Although there are mucus layers providing physical barriers against the large number of microbiota present in the large intestine, the mechanisms that separate bacteria and colonic epithelia are not fully elucidated. Here we show that Ly6/PLAUR domain containing 8 (Lypd8) protein prevents flagellated microbiota invading the colonic epithelia in mice. Lypd8, selectively expressed in epithelial cells at the uppermost layer of the large intestinal gland, was secreted into the lumen and bound flagellated bacteria including Proteus mirabilis. In the absence of Lypd8, bacteria were present in the inner mucus layer and many flagellated bacteria invaded epithelia. Lypd8−/− mice were highly sensitive to intestinal inflammation induced by dextran sulfate sodium (DSS). Antibiotic elimination of Gram-negative flagellated bacteria restored the bacterial-free state of the inner mucus layer and ameliorated DSS-induced intestinal inflammation in Lypd8−/− mice. Lypd8 bound to flagella and suppressed motility of flagellated bacteria. Thus, Lypd8 mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis.
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Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues.
Krishan Maggon 's curator insight,
March 31, 2016 2:23 AM
Mucosal Immunology (2016) 9, 38–55; doi:10.1038/mi.2015.34; published online 29 April 2015
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis L A Borthwick1,2,4, L Barron2,4, K M Hart2, K M Vannella2, R W Thompson2, S Oland2, A Cheever2, J Sciurba2, T R Ramalingam2, A J Fisher1,3 and T A Wynn2 1Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle Upon Tyne, UK 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 3Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne, UK Correspondence: TA Wynn, twynn@niaid.nih.gov
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RT @MicrobesInfect: Autonomous #immunity in mucosal epithelial cells: Fortifying the barrier against infection https://t.co/FcEtxmAjRv http…
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