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Scooped by
Gilbert C FAURE
October 29, 2016 2:03 PM
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Scooped by
Gilbert C FAURE
October 28, 2016 11:34 AM
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Suggested by
Société Francaise d'Immunologie
October 28, 2016 2:34 AM
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Scooped by
Gilbert C FAURE
October 26, 2016 11:58 AM
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Scooped by
Gilbert C FAURE
October 24, 2016 2:49 PM
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Levels of retinoic acid, a vitamin A metabolite, are low in mice and humans with colorectal cancer, according to new research. People with high levels of an enzyme that degrades retinoic acid have a poor prognosis.
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Scooped by
Gilbert C FAURE
October 23, 2016 12:44 AM
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When it comes to finding novel chemical compounds that act as antibiotics, scientists have to look in increasingly unusual places. Like sloth hair. And now, according to this study, Tasmanian devil milk.
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Suggested by
Société Francaise d'Immunologie
October 15, 2016 9:32 AM
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San Diego—Two novel therapies derived from a better understanding of the specific immunologic mediators of celiac disease have reached clinical trials and are showing promise fo
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Scooped by
Gilbert C FAURE
October 14, 2016 12:05 PM
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Swiss Med Wkly. 2016 Apr 5;146:w14293. doi: 10.4414/smw.2016.14293. eCollection 2016. Review
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Scooped by
Gilbert C FAURE
October 13, 2016 3:16 PM
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The probiotic yeast Saccharomyces boulardii has been shown to ameliorate disease severity in the context of many infectious and inflammatory conditions. However, use of S .
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Scooped by
Gilbert C FAURE
October 12, 2016 8:52 AM
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Scooped by
Gilbert C FAURE
October 11, 2016 11:10 AM
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Scooped by
Gilbert C FAURE
October 7, 2016 1:17 PM
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Scooped by
Gilbert C FAURE
October 7, 2016 10:09 AM
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If certain bacteria do instigate cancer, the finding could lead to new screening methods or treatments
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Scooped by
Gilbert C FAURE
October 29, 2016 1:49 PM
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Background. Lung CD4+ T-cell depletion and dysfunction, CD8+ T-cell alveolitis, smoking, and poor control of human immunodeficiency virus (HIV) are features of HIV-associated chronic obstructive pulmonary disease (COPD), but these changes have not...
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Suggested by
Société Francaise d'Immunologie
October 28, 2016 2:34 AM
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Discover how microbiome research is revealing the role that bacteria play in cancer treatment.
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Suggested by
LIGHTING
October 27, 2016 3:51 AM
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Scooped by
Gilbert C FAURE
October 24, 2016 2:52 PM
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Intestinal inflammation can impair mucosal healing, thereby establishing a vicious cycle leading to chronic inflammatory bowel disease (IBD). However, the signaling networks driving chronic inflammation remain unclear. Here we report that CD4+ T cells isolated from patients with IBD produce high levels of interleukin-22 binding protein (IL-22BP), the endogenous inhibitor of the tissue-protective cytokine IL-22. Using mouse models, we demonstrate that IBD development requires T cell–derived IL-22BP. Lastly, intestinal CD4+ T cells isolated from IBD patients responsive to treatment with antibodies against tumor necrosis factor–α (anti–TNF-α), the most effective known IBD therapy, exhibited reduced amounts of IL-22BP expression but still expressed IL-22. Our findings suggest that anti–TNF-α therapy may act at least in part by suppressing IL-22BP and point toward a more specific potential therapy for IBD.
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Scooped by
Gilbert C FAURE
October 23, 2016 1:02 AM
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Circulating follicular helper T (Tfh) cells are a heterogeneous population of CD4+ helper T cells that promotes pathogenic immune responses in autoimmune diseases.
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Scooped by
Gilbert C FAURE
October 21, 2016 1:56 AM
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Am J Med. 2005 Aug;118(8):899-906. Comparative Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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Suggested by
Société Francaise d'Immunologie
October 14, 2016 12:06 PM
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Semin Immunopathol. 2016 Jan;38(1):3-10. doi: 10.1007/s00281-015-0545-x. Epub 2015 Nov 12. Review
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Suggested by
LIGHTING
October 14, 2016 11:38 AM
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Innate lymphoid cells (ILCs) are innate immune cells that are ubiquitously distributed in lymphoid and nonlymphoid tissues and enriched at mucosal and barrier surfaces. Three major ILC subsets are recognized in mice and humans. Each of these subsets interacts with innate and adaptive immune cells and integrates cues from the epithelium, the microbiota, and pathogens to regulate inflammation, immunity, tissue repair, and metabolic homeostasis. Although intense study has elucidated many aspects of ILC development, phenotype, and function, numerous challenges remain in the field of ILC biology. In particular, recent work has highlighted key new questions regarding how these cells communicate with their environment and other cell types during health and disease. This review summarizes new findings in this rapidly developing field that showcase the critical role ILCs play in directing immune responses through their ability to interact with a variety of hematopoietic and nonhematopoietic cells. In addition, we define remaining challenges and emerging questions facing the field. Finally, this review discusses the potential application of basic studies of ILC biology to the development of new treatments for human patients with inflammatory and infectious diseases in which ILCs play a role.
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Scooped by
Gilbert C FAURE
October 13, 2016 2:27 PM
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Scooped by
Gilbert C FAURE
October 11, 2016 1:09 PM
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This Clinical Evidence Synopsis summarizes a Cochrane review of clinical trials comparing the effects of probiotics vs placebo, no treatment, or active treatmen
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Suggested by
LIGHTING
October 9, 2016 5:13 AM
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Scooped by
Gilbert C FAURE
October 7, 2016 1:12 PM
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PLoS One. 2016 Oct 6;11(10):e0164027. doi: 10.1371/journal.pone.0164027. eCollection 2016.
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