Immunology
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Immunology
Teaching and Learning Immunology. Information you never would have searched for!
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Scooped by Gilbert C FAURE
October 4, 2011 3:23 PM
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Microscopy, Immunohistochemistry, and Antigen Retrieval Methods ...

Microscopy, Immunohistochemistry, and Antigen Retrieval Methods ... | Immunology | Scoop.it
Microscopy, Immunohistochemistry, and Antigen Retrieval Methods: For Light and Electron Microscopy.
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Scooped by Gilbert C FAURE
October 4, 2011 3:20 PM
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Gus Nossal: It's Australian Jacques Miller's turn for a Nobel Prize - The Conversation

Gus Nossal: It's Australian Jacques Miller's turn for a Nobel Prize - The Conversation | Immunology | Scoop.it
The ConversationGus Nossal: It's Australian Jacques Miller's turn for a Nobel PrizeThe ConversationWhen examined under the microscope, the thymus gland contains billions of small round cells that look just like white blood cells known as small...
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Scooped by Gilbert C FAURE
October 3, 2011 3:33 AM
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High endothelial venules as traffic control points maintaining ...

Thus, rather than being simple entry ports, HEVs act as gatekeepers able to stack, hold and grant lymphocytes access to LN parenchyma in proportion to the rate of lymphocyte egress from the LN, enabling the LN to ...
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Scooped by Gilbert C FAURE
October 3, 2011 3:28 AM
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B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM ...

Rationale: Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized mice have led to the widely held notion ...
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October 3, 2011 3:22 AM
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Amazon.com: Innate and Adaptive Immunity in the Tumor Microenvironment (The Tumor Microenvironment) eBook: Eitan Yefenof: Kindle Store

Amazon.com: Innate and Adaptive Immunity in the Tumor Microenvironment (The Tumor Microenvironment) eBook: Eitan Yefenof: Kindle Store (Innate and Adaptive Immunity in the Tumor Microenvironment (The Tumor Microenvironment): Cancer cells are conti...)...
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Scooped by Gilbert C FAURE
October 2, 2011 11:21 AM
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Joseph Murray on the First Successful Human Organ Transplant

Joseph Murray on the First Successful Human Organ Transplant | Immunology | Scoop.it
The current issue of Harvard Medicine features an essay by Dr. Joseph Murray reflecting on the first successful organ transplantation. Murray discusses how his service as an army surgeon during World War II helped ...
Gilbert C FAURE's curator insight, November 17, 2014 8:50 AM

Joseph E. Murray ’43B, a professor of surgery emeritus at Harvard Medical School, was awarded the Nobel Prize in Physiology or Medicine in 1990. A more complete story of human organ transplantation can be found in his autobiography, Surgery of the Soul (Science History Publications/USA, 2001). Anthony L. Komaroff, with whom he collaborated on the book and this article, is the Simcox–Clifford–Higby Professor of Medicine at Harvard Medical School and editor–in–chief of Harvard Health Publications.

 

Scooped by Gilbert C FAURE
September 30, 2011 4:39 AM
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Seven scientists awarded Shaw Prize in Hong Kong - Xinhua

XinhuaSeven scientists awarded Shaw Prize in Hong KongXinhua...
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September 29, 2011 12:09 PM
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YM BioSciences Announces Nimotuzumab Data to be Reported at 2011 ECCO-ESMO ... - MarketWatch (press release)

YM BioSciences Announces Nimotuzumab Data to be Reported at 2011 ECCO-ESMO ... - MarketWatch (press release) | Immunology | Scoop.it
YM BioSciences Announces Nimotuzumab Data to be Reported at 2011 ECCO-ESMO ...MarketWatch (press release)A poster presentation entitled "Pilot Study of Target Therapy With EGFR Antibody (Nimotuzumab) in Patients With Unresectable Head and Neck Cancer"...
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Scooped by Gilbert C FAURE
September 27, 2011 8:35 AM
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OMICS Publishing Group | Full-text | Innate Immunity in the Lower Female Mucosal Tract

OMICS Publishing Group | Full-text | Innate Immunity in the Lower Female Mucosal Tract | Immunology | Scoop.it
In the current issue of Journal of Steroids & Hormonal Science Innate Immunity in the Lower Female Mucosal Tract...
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Scooped by Gilbert C FAURE
September 27, 2011 8:28 AM
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Horizon scanning: Phase II data for antibody drug conjugate T-DM1 ...

T-DM1 is an antibody drug conjugate which contains chemotherapy (maytansine) stably linked to trastuzumab (Herceptin®) – this both inhibits HER2 signalling and delivers the chemotherapy directly inside HER2-positive ...
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Scooped by Gilbert C FAURE
September 25, 2011 2:14 PM
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Eculizumab Gains FDA Approval - Drug Discovery & Development

Eculizumab Gains FDA ApprovalDrug Discovery & DevelopmentEculizumab is a monoclonal antibody that inhibits the production of the terminal complement components C5a and the membrane attack complex C5b-9 by binding to complement protein C5.
Gilbert C FAURE's insight:

Eculizumab is a monoclonal antibody that inhibits the production of the terminal complement components C5a and the membrane attack complex C5b-9 by binding to complement protein C5. Prevention of C5a formation and the terminal complement complex inhibits complement-mediated thrombotic microangiopathy in patients with aHUS.

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September 25, 2011 2:11 PM
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Cancer study boosts hopes for Roche's armed antibody | Reuters

Cancer study boosts hopes for Roche's armed antibody | Reuters | Immunology | Scoop.it
STOCKHOLM (Reuters) - Women with an aggressive type of advanced breast cancer can live significantly longer without their disease getting worse if they are treated with an experimental armed antibody drug (Cancer study boosts hopes for Roche's armed...
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Scooped by Gilbert C FAURE
September 22, 2011 11:11 AM
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Amazon.com: Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity eBook: C. Jane Welsh, Mary Meagher, Esther Sternberg: Kindle Store

Amazon.com: Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity eBook: C.
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Scooped by Gilbert C FAURE
October 4, 2011 3:21 PM
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La Jolla Institute discovers previously unknown cell interaction key in immune ... - EurekAlert (press release)

La Jolla Institute discovers previously unknown cell interaction key in immune ...EurekAlert (press release)A major discovery by La Jolla Institute scientist Amnon Altman, Ph.D., and his colleagues, of a previously unknown molecular interaction that...
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Scooped by Gilbert C FAURE
October 4, 2011 3:18 PM
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The Nobel Prize in Physiology or Medicine 2011: Bruce A. Beutler ...

The Nobel Prize in Physiology or Medicine 2011: Bruce A. Beutler ... | Immunology | Scoop.it
Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. J Exp Med 1973;137:1142-1162. Steinman RM, Witmer MD. Lymphoid dendritic cells are potent stimulators of the primary mixed ...
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Scooped by Gilbert C FAURE
October 3, 2011 3:30 AM
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Autoimmune Arthritis | Scientists Crack Sparse Genome Of Microbe Linked To Autoimmunity | Arthritis imformation station

Autoimmune Arthritis | Scientists Crack Sparse Genome Of Microbe Linked To Autoimmunity | Arthritis imformation station | Immunology | Scoop.it
Research Adds to Growing Knowledge of How Gut Bacteria Influence Health Newswise - NEW YORK, September 14 2011 (Autoimmune Arthritis | Scientists Crack Sparse Genome Of Microbe Linked To Autoimmunity: Research Adds to Growin...)...
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Scooped by Gilbert C FAURE
October 3, 2011 3:24 AM
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The Khan Academy

The Khan Academy | Immunology | Scoop.it
The Khan Academy is a not-for-profit 501(c)(3) with the mission of providing a world-class education to anyone, anywhere.
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Scooped by Gilbert C FAURE
October 3, 2011 3:16 AM
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Humoral immunity and antibody-mediated rejecti... [Semin Immunol. 2011] - PubMed - NCBI

PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Abstract

The humoral arm of the immune system provides robust protection against extracellular pathogens via the production of antibody molecules that neutralize or facilitate the destruction of microorganisms. However, the humoral immune system also provides a significant barrier to solid organ transplantation due to the antibody-mediated recognition of non-self proteins and carbohydrates expressed on transplanted organs. Historically, the presence of donor-specific antibodies (DSA) that recognize donor HLA molecules, incompatible ABO blood group antigens and other endothelial or xenogeneic antigens was considered a contraindication to transplantation. However, recent advances in antibody testing and immunosuppressive therapies have made it possible to cross certain antibody barriers successfully. In this article, we review our current understanding of antibody-mediated processes in solid organ transplantation and discuss the clinically available treatment options for preventing and treating antibody-mediated rejection.

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Scooped by Gilbert C FAURE
September 30, 2011 4:40 AM
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Hide-And-Seek: Altered HIV Can't Evade Immune System - Science Daily (press release)

Hide-And-Seek: Altered HIV Can't Evade Immune System - Science Daily (press release) | Immunology | Scoop.it
Hide-And-Seek: Altered HIV Can't Evade Immune SystemScience Daily (press release)"The altered HIV doesn't overwhelm the system and instead triggers the innate immune response to kick in, like it does with any first virus encounter," says Graham.
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Scooped by Gilbert C FAURE
September 29, 2011 12:12 PM
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Amazon.com: Innate Immunity of Plants, Animals and Humans (Nucleic Acids and Molecular Biology) (9783540739296): Holger Heine: Books

Amazon.com: Innate Immunity of Plants, Animals and Humans (Nucleic Acids and Molecular Biology) (9783540739296): Holger Heine: Books (GET IT NOW!
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Scooped by Gilbert C FAURE
September 29, 2011 12:06 PM
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Investigators Identify CD8 T Cell Transcription Signature that Predicts ... - Genetic Engineering News

Investigators Identify CD8 T Cell Transcription Signature that Predicts ... - Genetic Engineering News | Immunology | Scoop.it
Investigators Identify CD8 T Cell Transcription Signature that Predicts ...Genetic Engineering NewsCD4 and CD8 T cells were positively selected from peripheral blood mononuclear cells (PBMCs) for whole-genome transcriptional analyses, and the...
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Scooped by Gilbert C FAURE
September 27, 2011 8:33 AM
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WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity http://t.co/LsoHtDXn #JEMTCB...
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Scooped by Gilbert C FAURE
September 27, 2011 8:25 AM
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Bone marrow vaccination: A novel approach to enhance antigen specific antitumor immunity - Life Sciences Social Network

Bone marrow vaccination: A novel approach to enhance antigen specific antitumor immunity - Life Sciences Social Network | Immunology | Scoop.it
Bone marrow vaccination: A novel approach to enhance antigen specific antitumor immunity (Bone marrow vaccination: A novel approach to enhance antigen specific antitumor immunity http://t.co/6oohcpjv...)...
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Scooped by Gilbert C FAURE
September 25, 2011 2:12 PM
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{gamma}-Interferon-regulated chaperone governs human... [FASEB J. 2011] - PubMed - NCBI

PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
September 25, 2011 2:09 PM
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Human leukocyte antigen I knockdown human embryonic stem cells ...

Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival. Circulation. 2011 Sep 13;124(11 Suppl):S3-9. Authors: Deuse T, Seifert M, Phillips N, ...
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