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Immunology

Teaching and Learning Immunology. Information you never would have searched for!

Curated by Gilbert C FAURE

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Rescooped by Gilbert C FAURE from Cancer Immunotherapy Review and Collection

November 30, 2015 5:23 AM

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From www.cell.com - November 30, 2015 5:21 AM

Gilbert C FAURE's insight:

Single-cell approaches will be essential to improving our understanding of T lymphocyte fate determination and to advancing vaccination and therapeutic approaches that enhance long-term protective immune responses.

major new concept

Krishan Maggon 's curator insight, November 30, 2015 5:21 AM

Trends Immunology

Volume 36, Issue 11, p670–683, November 2015

DOI: http://dx.doi.org/10.1016/j.it.2015.09.004

Asymmetric Cell Division in T Lymphocyte Fate Diversification

Opinion

Janilyn Arsenio, Patrick J. Metz, John T. Chang

Suggested by Société Francaise d'Immunologie

November 28, 2015 2:16 PM

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From news.google.com - November 25, 2015 1:11 PM

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Scooped by Gilbert C FAURE

November 27, 2015 9:04 AM

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Phenotypic and Functional Properties of Human Steady State CD14+ and CD1a+ Antigen Presenting Cells and Epidermal Langerhans Cells | Immunology | Scoop.it

From journals.plos.org - November 25, 2015 5:00 PM

Gilbert C FAURE's insight:

The results demonstrate that under steady state conditions human CD1a+ dermal dendritic cells (DCs) were phenotypically most mature as measured by the expression of CD83 and CD86, whereas the CD14+ cells showed a higher expression of the CLRs DC-SIGN, mannose receptor and DCIR and had potent antigen uptake capacity. Furthermore, steady state LCs showed superior antigen cross-presentation as compared to the dermal APC subsets. Our results also demonstrate that the TLR3 ligand polyribosinic-polyribocytidylic acid (pI:C) was the most potent stimulator of cytokine production by both LCs and dDCs. These studies warrant further exploration of human CD1a+ dDCs and LCs as target cells for cancer vaccination to induce anti-tumor immune responses.

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Scooped by Gilbert C FAURE

November 26, 2015 9:58 AM

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From news.google.com - July 23, 2015 9:22 AM

Gilbert C FAURE's insight:

Universally expressed CD59 is the sole membrane complement regulatory protein that protects host cells from complement damage by restricting membrane attack complex assembly. The human gene encodes a single CD59, whereas the mouse gene encodes a duplicated CD59, comprising mCd59a and mCd59b, with distinct tissue distribution.

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Scooped by Gilbert C FAURE

November 26, 2015 9:49 AM

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From www.immunology.org - November 26, 2015 3:46 AM

Gilbert C FAURE's insight:

“The British Society for Immunology welcomes the announcement by the UK Government in today’s Comprehensive Spending review that the science budget will be protected in real terms, and that there will be extra money for the NHS. The UK’s ability to conduct high-quality, cutting edge fundamental research is a critical factor in our ability to understand the science behind immunological and infectious disease and to find new approaches to prevention and treatment of these important and sometimes devastating conditions. Science and innovation are key factors in growing this country’s economy and contributing to our national successes. Good science costs money, but is well worth the investment. - See more at: https://www.immunology.org/page.aspx?pid=1417#sthash.nFCeiA6q.dpuf

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Scooped by Gilbert C FAURE

November 26, 2015 9:35 AM

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From ici2016.org - November 26, 2015 9:35 AM

Gilbert C FAURE's insight:

Basic Immunology Course

Date and time: Sunday 21 August – 0900-1630
Venue: Melbourne Convention and Exhibition Centre
Lecturers: A team of expert international immunologists who will present an update and new concepts in basic and translational immunology
Target audience: The target audience is mainly PhD students, younger scientists and academic physicians but all are welcome. This course will be of value to those new to the field as well as those seeking a refresher on core material and update on cutting edge developments.
Presentations will be made available to participants and there will be ample time for discussion
Attendance certificates will be provided to participants
Registration fee: A$150

and

Clinical Immunology Course

Date and time: Sunday 21 August – 0900-1630
Venue: Melbourne Convention and Exhibition Centre
Lecturers: A team of outstanding international clinical immunologists who will present an update on underlying immune mechanisms of immune disorders, as well as advances in diagnosis and treatment, especially immunotherapies.
Target audience: The target audience is mainly PhD students, younger scientists and academic physicians but all are welcome. This course will be of value to those new to the field as well as those seeking a refresher on core material and update on cutting edge developments.
Presentations will be made available to participants and there will be ample time for discussion. In this course, lecturers will include case studies to further enhance discussion and appreciation of new insights.
Presentations will be made available to participants
Attendance certificates will be provided to participants
Registration fee: A$150

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Scooped by Gilbert C FAURE

November 24, 2015 2:20 PM

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From intimm.oxfordjournals.org - November 23, 2015 11:06 PM

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Scooped by Gilbert C FAURE

November 24, 2015 2:17 PM

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From journal.frontiersin.org - November 24, 2015 2:51 AM

Gilbert C FAURE's insight:

Perhaps the most intriguing and underappreciated of these “sentinel” roles is the ability of the endothelium to act as a non-hematopoietic “semiprofessional” antigen-presenting cell. Close contacts between circulating T cells and antigen-presenting endothelium may play unique non-redundant roles in shaping adaptive immune responses within the periphery. A better understanding of the mechanisms directing T cell trafficking and the antigen-presenting role of the endothelium may not only increase our knowledge of the adaptive immune response but also empower the utility of emerging immunomodulatory therapeutics.

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Scooped by Gilbert C FAURE

November 23, 2015 3:53 AM

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From www.nature.com - November 19, 2015 5:46 AM

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abstract

The neural hard-wired pathways in which the lymphoid organs are innervated by the nervous system is of special interest with respect to suggested afferent and sensory systems informing the central nervous system about the status of the immune system. Until today efferent also like afferent innervation seem to be unspecific, targeting many types of cells by affecting many cells at the same time. We for the first time show that antigen presenting cells (APC) are abundantly innervated in the T-cell enriched area, the subsinoidal layer and the cortical extrafollicular zone of lymph nodes in rats by a mesh of filamentous neurofilament positive structures originating from single nerve fibers and covering each single APC similar to a glass fishing float, so that we termed them “wired” APC (wAPC). These wAPC also found in humans seem to be restricted to the cell body, not to follow membranous extensions, they may be dynamic and receptive as MAP2 is expressed and axonal growth cones can be detected and they probably lack vesicular activity through missing synaptophysin expression. The specific innervation targeting single cells which show a distribution divided in several areas in one lymph node suggests a form of topographically organized afferent sensory system.

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Scooped by Gilbert C FAURE

November 22, 2015 1:42 PM

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From news.google.com - September 11, 2015 2:46 AM

Gilbert C FAURE's insight:

An increasing number of studies indicate that innate immune cells can show memory-like behaviour. One of the key mechanisms that mediates these effects is epigenetic reprogramming, but how pathogens can induce these changes is unclear. Now, Yoshida et al. show that the stress response transcription factor ATF7 mediates lipopolysaccharide (LPS)-induced epigenetic changes in macrophages a…

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Scooped by Gilbert C FAURE

November 21, 2015 2:40 AM

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Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems - Geiger - 2015 - Immunology - Wiley Online Library | Immunology | Scoop.it

From onlinelibrary.wiley.com - November 20, 2015 5:21 PM

Gilbert C FAURE's insight:

Summary

Development of inflammatory diseases, such as metabolic syndrome and cancer, is prevalent in individuals that encounter continuous disruption of their internal clock. Further, daily oscillations in susceptibility to infection as well as a multitude of other immunological processes have been described. Much progress has been made and various mechanisms have been proposed to explain circadian variations in immunity; yet much is still unknown. Understanding the crosstalk between the circadian and the immune systems will allow us to manipulate clock outputs to prevent and treat inflammatory diseases in individuals at risk. This review briefly summarizes current knowledge about circadian rhythms and their role in the immune system and highlights progress and challenges in chrono-immunological research.

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Scooped by Gilbert C FAURE

November 19, 2015 4:13 PM

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From www.news-medical.net - November 11, 2015 8:38 AM

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Rescooped by Gilbert C FAURE from Immunology, vaccine & infectious diseases

November 19, 2015 4:45 AM

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From journal.frontiersin.org - November 18, 2015 3:35 PM

Gilbert C FAURE's insight:

The actin cytoskeleton is composed of a dynamic filament meshwork that builds the architecture of the cell to sustain its fundamental properties. This physical structure is characterized by a continuous remodeling, which allows cells to accomplish complex motility steps such as directed migration, crossing of biological barriers, and interaction with other cells. T lymphocytes excel in these motility steps to ensure their immune surveillance duties. In particular, actin cytoskeleton remodeling is a key to facilitate the journey of T lymphocytes through distinct tissue environments and to tune their stop and go behavior during the scanning of antigen-presenting cells. The molecular mechanisms controlling actin cytoskeleton remodeling during T lymphocyte motility have been only partially unraveled, since the function of many actin regulators has not yet been assessed in these cells.....

OPEN

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Scooped by Gilbert C FAURE

November 29, 2015 1:58 PM

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From www.nature.com - November 26, 2015 1:17 PM

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Scooped by Gilbert C FAURE

November 27, 2015 9:20 AM

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From www.nature.com - November 27, 2015 9:20 AM

Gilbert C FAURE's insight:

The rapid detection of microbial agents is essential for the effective initiation of host defence mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger innate immune gene transcription has important implications — not only for comprehending the immune response to pathogens but also for elucidating the causes of autoinflammatory disease involving the sensing of self-DNA and the generation of effective antitumour adaptive immunity. The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signalling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer.

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Scooped by Gilbert C FAURE

November 27, 2015 5:35 AM

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From www.sciencedaily.com - November 26, 2015 10:40 AM

Gilbert C FAURE's insight:

"The changes found in the bat TLRs could reflect the reservoir status described for some bat species carrying specific pathogens," explains Alex Greenwood, head of the Department of Wildlife Diseases at the IZW. Despite the wide acceptance of bats as reservoirs for different pathogens, the genetic variability of the bat immune system underlying such observation has been little investigated. The recent study reveals insights which show that this variability exists and in which direction the genetic basis of parts of the bat immune system deviates from those of other mammals.

Marina Escalera-Zamudio, M. Lisandra Zepeda-Mendoza, Elizabeth Loza-Rubio, Edith Rojas-Anaya, Maria L. Méndez-Ojeda, Carlos F. Arias, Alex D. Greenwood. The evolution of bat nucleic acid-sensing Toll-like receptors. Molecular Ecology, 2015; 24 (23): 5899 DOI:10.1111/mec.13431

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Scooped by Gilbert C FAURE

November 26, 2015 9:51 AM

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From www.nature.com - November 24, 2015 5:56 AM

Gilbert C FAURE's insight:

A secreted protein of S. aureus, known as eLtaS, is an extracellular protein released from the bacterial membrane protein, LtaS. However, the role of eLtaS in S. aureus pathogenesis remains largely unknown. Here we show eLtaS dramatically aggravates S. aureus infection by binding to C3b and then inhibiting the phagocytosis of C3b-deposited S. aureus.

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Scooped by Gilbert C FAURE

November 26, 2015 9:48 AM

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From britsocimmblog.org - November 26, 2015 2:30 AM

Gilbert C FAURE's insight:

stimulating title from convinced investors!

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November 26, 2015 9:28 AM

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From www.novartisimmunologyprizes.com - November 26, 2015 9:28 AM

Gilbert C FAURE's insight:

The awards

Every three years, the Novartis Prizes for Immunology jury (an independent panel of world-leading experts) award one prize for basic research and another for clinical research, each worth CHF 100,000. This is made possible by the generosity of the Novartis Institute for Biomedical Research (NIBR).

The ceremony

The award ceremony will be held at the 16th International Congress of Immunology (ICI) in August 2016 in Melbourne, Australia. We hope you will be able to join us in celebrating the 25th anniversary of the awards, which first took place in 1990.

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Scooped by Gilbert C FAURE

November 24, 2015 2:18 PM

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EMBO|EMBL Symposium: Innate Immunity in Host-Pathogen Interactions hosted by European Molecular Biology Laboratory, EMBL Heidelberg in Heidelberg, Baden-Württemberg | Immunology | Scoop.it

From www.eventsetter.com - November 23, 2015 5:33 AM

Gilbert C FAURE's insight:

A better understanding of infectious disease will come through the simultaneous analysis of microbial and host variables, and open new avenues for treatment and prevention strategies.

This meeting will stimulate interactions between the fields of innate immunity and microbiology, and provide a global view of host-pathogen interactions. Understanding when and how an interaction between host and microbe (virus, bacteria or parasite) leads to disease will open new avenues for treatment and prevention strategies.

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Scooped by Gilbert C FAURE

November 24, 2015 2:24 AM

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From www.jsi-men-eki.org - November 23, 2015 4:26 PM

Gilbert C FAURE's insight:

Symposia on cutting-edge topics in current immunology are being planned with leading researchers invited from all over the world. There will also be open Workshops covering the entire scope of immunology. These sessions will all be conducted in English, and participants from overseas, including Asian countries, will be most welcome. The “Call for papers” is scheduled to open soon, and abstract submissions from overseas researchers are also welcome. I am sure that the crisp weather in Sapporo will cool you down after the hot discussion during the meeting.

We welcome all of you and sincerely look forward to your abstract submissions and participation in the exciting JSI Annual Meeting in Sapporo.

Shigeo KOYASU

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Scooped by Gilbert C FAURE

November 22, 2015 1:44 PM

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From www.youtube.com - November 21, 2015 5:43 AM

Gilbert C FAURE's insight:

royal college of Physicians inside

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Scooped by Gilbert C FAURE

November 22, 2015 1:23 PM

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From www.nature.com - November 17, 2015 5:41 AM

Gilbert C FAURE's insight:

..... severe influenza disease in Indigenous Australians
OPEN

study indicates a need to identify novel influenza-specific CD8+ T-cell epitopes restricted by HLA-A and HLA-B alleles prevalent in Indigenous populations for the rational design of universal T-cell vaccines.

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Scooped by Gilbert C FAURE

November 20, 2015 7:25 AM

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From www.nature.com - November 20, 2015 7:25 AM

Gilbert C FAURE's insight:

In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as a danger molecule that communicates to the immune system that the tissue is under attack and poises it to mediate tissue destruction. More specifically, we propose that expression of IL-15 in tissues promotes T helper 1 cell-mediated immunity and provides co-stimulatory signals to effector cytotoxic T cells to exert their effector functions and drive tissue destruction. Therefore, we think that IL-15 contributes to tissue protection by promoting the elimination of infected cells but that when its expression is chronically dysregulated, it can promote the development of complex T cell-mediated disorders associated with tissue destruction, such as coeliac disease and type 1 diabetes.

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Scooped by Gilbert C FAURE

November 19, 2015 7:06 AM

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From www.immunology.org.au - November 19, 2015 1:41 AM

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Immunology

Asymmetric Cell Division in T Lymphocyte Fate Diversification: Trends in Immunology

Immunology: In the right place at the right time - Nature.com

Phenotypic and Functional Properties of Human Steady State CD14+ and CD1a+ Antigen Presenting Cells and Epidermal Langerhans Cells

Mouse Cd59b but not Cd59a is upregulated to protect cells from complement ... - Nature.com

Home Page - British Society for Immunology

ICI 2016 – International Congress of Immunology 2016 | 21-26 August 2016, Melbourne, Australia

TLR7 and TLR9 ligands regulate antigen presentation by macrophages

T Lymphocyte-Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity

Dendritic cells and macrophages neurally hard-wired in the lymph node - Nature.com

Controlling innate immune memory - Nature.com

Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems - Geiger - 2015 - Immunology - Wiley Online Library

Biocept receives European patent covering antibody usage in capture of rare cells - News-Medical.net

T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors

Antibody anarchy: A call to order : Nature : Nature Publishing Group

STING: infection, inflammation and cancer

Bat immune receptors are one of a kind

MAE4, an eLtaS monoclonal antibody, blocks Staphylococcus aureus virulence - Nature.com

Investment in immunology: the key for future success

Novartis Prizes for Immunology

EMBO|EMBL Symposium: Innate Immunity in Host-Pathogen Interactions hosted by European Molecular Biology Laboratory, EMBL Heidelberg in Heidelberg, Baden-Württemberg

2015 Annual Meeting of the Japanese Society for Immunology

Immunology Describe your specialty 30 sec challenge

Towards identification of immune and genetic correlates of severe influenza ... - Nature.com

IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction

Expressions of interest sought – FIMSA Advanced Course – Chandigarh, India | Australasian Society for Immunology |