AUTOIMMUNITY

Garvan scientists have confirmed a ‘weak link’ in the immune system – identifying the exact conditions under which an infection can trigger an autoantibody response, a process not clearly understood until now.

J Clin Endocrinol Metab. 2013 Sep 24. [Epub ahead of print]

IODINE CONTRIBUTES TO THYROID AUTOIMMUNITY IN HUMANS BY UNMASKING A CRYPTIC EPITOPE ON... (J Clin Endocrinol Metab. 2013 Sep 24.

Clinical and Developmental Immunology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas related to developmental immunology and clinical immunologic studies.

Private MD More people may have celiac disease than previously estimated Private MD The study, published in the BMC Journal, involved 2,500 Australian men and women who were given blood tests as well as the more typical antibody testing for celiac...

"When associated with CVID, a single TACI mutation predicts the development of autoantibody-mediated autoimmune disease, whereas patients with two mutated alleles are mostly spared clinical autoimmune conditions, ...

Disease Markers is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies related to all aspects of disease markers.

Lymphocyte receptor diversity is generated by recombining variable, diversity, and joining (VDJ) gene segments of the immunoglobulin and T-cell receptor (TCR) loci. V(D)J recombination requires DNA breakage, a process mediated by recombination-activating gene (RAG) 1 and 2. RAG deficiency was initially described in patients with the T−B− severe combined immunodeficiency (SCID) phenotype1; however, the spectrum of the disease has expanded to include Omenn syndrome, cytomegalovirus infection with γδ T-cell expansion, combined immunodeficiency with granuloma, and isolated CD4+ lymphopenia.2, 3, 4, 5, 6 The pleomorphic manifestations of RAG deficiency are partially explained by residual RAG activity, with null mutations producing an SCID phenotype and hypomorphic mutations presenting more variably.2, 7 Although autoimmunity is a known feature of aberrant RAG function, it has never been described as the primary manifestation of the disease in an infant. We describe a novel presentation of RAG deficiency characterized by the presence of B cells and early-onset autoimmunity.

Diabetes: More than just type 1 or type 2
The Virtual Medical Centre
Of that number, 522 exhibited two or more diabetes-specific antibodies while 64 participants in the study displayed one antibody. In 44 of the participants no antibodies were found.

The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis #mecfs (ME/cfs) http://t.co/WYaB4EZbHF #springerlink

Abstract. Although a population of T cells with CD3ζ chain deficiency has been found in patients with systemic lupus erythematosus, rheumatoid arthritis, cancer, and infectious disease, the role of CD3ζ chain in the disease ...

Immune protein explains skin diseases' link to infection
Science News
Some of the immune cells that cause the inflammatory skin disease psoriasis may also stave off viral infections, a new study suggests.

RT @BSIHQ: Partners in crime? Mast cells, glia and neuroinflammation. Free article from #immunology http://t.co/Loe3UyyAeX http://t.co/JhUu…;