AUTOIMMUNITY
20.9K views | +14 today
AUTOIMMUNITY
Pathology, Diagnosis and Therapies
Your new post is loading...
Your new post is loading...
Scooped by Gilbert C FAURE
November 29, 2013 3:49 AM
Scoop.it!

Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation

Our paper just published in PNAS on autoimmunity following T cell depletion with alemtuzumab: http://t.co/6mWxXapX4m
Gilbert C FAURE's insight:

side effect of Moab

Gilbert C FAURE's comment, November 29, 2013 3:56 AM
similar to what can occur in HIV patients?
Scooped by Gilbert C FAURE
November 27, 2013 3:14 PM
Scoop.it!

Autoimmune hepatitis - 2013 Lancet review - CasesBlog - Blogger

Autoimmune hepatitis - 2013 Lancet review - CasesBlog - Blogger | AUTOIMMUNITY | Scoop.it
In common with many autoimmune diseases, autoimmune hepatitis is associated with non-organ-specific antibodies in the context of hepatic autoimmunity. Autoimmune hepatitis can present in acute or chronic forms.
No comment yet.
Scooped by Gilbert C FAURE
November 26, 2013 1:21 PM
Scoop.it!

Frontiers | MHC Class II Protein Turnover In vivo and Its Relevance for Autoimmunity in Non-Obese Diabetic Mice | Frontiers in Antigen Presenting Cell Biology

MHCII proteins are loaded with endosomal peptides and reside at the surface of antigen-presenting cells (APCs) for a time before being degraded.
No comment yet.
Scooped by Gilbert C FAURE
November 26, 2013 6:11 AM
Scoop.it!

Identifying targets of new autoantibodies in SLE with protein array - JCI via EurekAlert

Identifying targets of autoantibodies
EurekAlert (press release)
Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems.
Gilbert C FAURE's insight:

link to JCI for anti-BAFF autoantibodies in severe lupus.

protein arrays become rewarding!

and lupus patients are making all autoantibodies they want, the ones we know and others we don't know yet!

No comment yet.
Scooped by Gilbert C FAURE
November 24, 2013 10:21 AM
Scoop.it!

Anti-transcription intermediary factor 1-γ autoantibody ELISA development and validation

Anti-transcription intermediary factor 1-γ autoantibody ELISA development and validation | AUTOIMMUNITY | Scoop.it
Internal Medicine Medical Article: Anti-transcription intermediary factor 1-γ autoantibody ELISA development and validation (Dr Rohit Aggarwal just commented on: Anti-transcription intermediary factor 1-γ autoantibody...
Gilbert C FAURE's insight:

myositis

No comment yet.
Scooped by Gilbert C FAURE
November 23, 2013 10:26 AM
Scoop.it!

Pemphigus Foliaceus Associated with Anti-NXP2 Autoantibody-positive Dermatomyositis - Abstract - Acta Dermato-Venereologica - Content

Pemphigus Foliaceus Associated with Anti-NXP2 Autoantibody-positive Dermatomyositis - Abstract - Acta Dermato-Venereologica - Content | AUTOIMMUNITY | Scoop.it
Abstract is missing (Short)... (Preview of article: Pemphigus Foliaceus Associated with Anti-NXP2 Autoantibody-positive Dermatomyositis...
No comment yet.
Scooped by Gilbert C FAURE
November 22, 2013 1:20 PM
Scoop.it!

Clinical Immunology | Vol 149, Iss 2, Pgs 169-264, (November, 2013) | ScienceDirect.com

Clinical Immunology | Vol 149, Iss 2, Pgs 169-264, (November, 2013) | ScienceDirect.com | AUTOIMMUNITY | Scoop.it
The online version of Clinical Immunology at ScienceDirect.com, the world's leading platform for high quality peer-reviewed full-text journals.
Gilbert C FAURE's insight:

sex and autoimmunity

No comment yet.
Scooped by Gilbert C FAURE
November 22, 2013 4:26 AM
Scoop.it!

Frontiers | Long-lived plasma cells in autoimmunity: lessons from B-cell depleting therapies. | Frontiers in B Cell Biology

A large number of autoimmune diseases are treated by Rituximab, an antibody against CD20 that depletes most of the B cells in the organism.
No comment yet.
Scooped by Gilbert C FAURE
November 19, 2013 8:37 AM
Scoop.it!

Trends in Immunology - A20 in inflammation and autoimmunity

RT @ImmunityCP: TrendsImmunol: van Loo and colleagues review A20 function in #inflammation and #autoimmunity. http://t.co/7IxHVP6ZiD
Gilbert C FAURE's insight:

Although known for many years as a nuclear factor (NF)-κB inhibitory and antiapoptotic signaling protein, A20 has recently attracted much attention...

No comment yet.
Scooped by Gilbert C FAURE
November 18, 2013 4:35 AM
Scoop.it!

Autoantibody and HLA Profiles in Children With Autoimmune Li... : Journal of Pediatric Gastroenterology and Nutrition

Objectives: Familial clustering of juvenile autoimmune liver disease (AILD), including autoimmune hepatitis (AIH) and autoimmune sclerosing cholangitis (ASC), is rare, despite a high prevalence of autoimmune disorders in AILD families.
Gilbert C FAURE's insight:

rare diseases, but

No comment yet.
Scooped by Gilbert C FAURE
November 17, 2013 1:02 PM
Scoop.it!

Antibody response against gastrointestinal anti... [Eur J Neurol. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
No comment yet.
Scooped by Gilbert C FAURE
November 17, 2013 3:48 AM
Scoop.it!

PLOS ONE: Low Incidence of Spontaneous Type 1 Diabetes in Non-Obese Diabetic Mice Raised on Gluten-Free Diets Is Associated with Changes in the Intestinal Microbiome

PLOS ONE: Low Incidence of Spontaneous Type 1 Diabetes in Non-Obese Diabetic Mice Raised on Gluten-Free Diets Is Associated with Changes in the Intestinal Microbiome | AUTOIMMUNITY | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
No comment yet.
Scooped by Gilbert C FAURE
November 16, 2013 6:12 AM
Scoop.it!

Evidence for oesophageal and anorectal involvement in very early systemic sclerosis (VEDOSS): Report from a single VEDOSS/EUSTAR centre

Evidence for oesophageal and anorectal involvement in very early systemic sclerosis (VEDOSS): Report from a single VEDOSS/EUSTAR centre | AUTOIMMUNITY | Scoop.it
Rheumatology Medical Article: Evidence for oesophageal and anorectal involvement in very early systemic sclerosis (VEDOSS): Report from a single VEDOSS/EUSTAR centre (Evidence for oesophageal and anorectal involvement in very early systemic...
No comment yet.
Scooped by Gilbert C FAURE
November 27, 2013 3:15 PM
Scoop.it!

The Breviary: Natural history of celiac disease autoimmunity in a ...

CD autoimmunity was detected in seven subjects in 1974 (prevalence 1:501) and in an additional nine subjects in 1989 (prevalence 1:219). Two cases of CD autoimmunity were found among the 840 subjects deceased after ...
No comment yet.
Scooped by Gilbert C FAURE
November 26, 2013 1:22 PM
Scoop.it!

Standardization of autoantibody testing: a paradigm for serology in rheumatic diseases : Nature Reviews Rheumatology : Nature Publishing Group

No comment yet.
Scooped by Gilbert C FAURE
November 26, 2013 1:21 PM
Scoop.it!

Thyroid autoimmunity in Type 1 diabetes: systemat... [Diabet Med. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
No comment yet.
Scooped by Gilbert C FAURE
November 25, 2013 2:30 PM
Scoop.it!

Pathogenesis of ANCA-associated vasculitis: recent insights... : Current Opinion in Rheumatology

Pathogenesis of ANCA-associated vasculitis:  recent insights... : Current Opinion in Rheumatology | AUTOIMMUNITY | Scoop.it
Purpose of review: To provide an update on animal models of antineutrophil cytoplasmic autoantibody (ANCA)-mediated vasculitis and highlight recent insights gained from studies in these models pertaining to immunopathogenesis.
No comment yet.
Scooped by Gilbert C FAURE
November 23, 2013 10:26 AM
Scoop.it!

Islet-Specific T-Cell Responses and Proinflammatory Monocytes Define Subtypes of Autoantibody-Negative Ketosis-Prone Diabetes

Islet-Specific T-Cell Responses and Proinflammatory Monocytes Define Subtypes of Autoantibody-Negative... http://t.co/c9KL69VXma
No comment yet.
Scooped by Gilbert C FAURE
November 22, 2013 2:16 PM
Scoop.it!

Vasculitis damage swift, accumulating - medwireNews

Vasculitis damage swift, accumulating - medwireNews | AUTOIMMUNITY | Scoop.it
Vasculitis damage swift, accumulating medwireNews medwireNews: Study findings reveal the significant burden of disease among patients with antineutrophil-cytoplasm antibody associated vasculitis (AAV), with many individuals showing irreversible...
No comment yet.
Scooped by Gilbert C FAURE
November 22, 2013 7:08 AM
Scoop.it!

Breaking the Code: UCSB Researchers Link Antibodies to Certain Diseases - Noozhawk

Breaking the Code: UCSB Researchers Link Antibodies to Certain Diseases - Noozhawk | AUTOIMMUNITY | Scoop.it
Noozhawk
Breaking the Code: UCSB Researchers Link Antibodies to Certain Diseases
Noozhawk
...
Gilbert C FAURE's insight:

peptidomics might invent new ways of analysing antoimmunity, or will it be a new deadend?

No comment yet.
Rescooped by Gilbert C FAURE from Innovation in Science, Health Research
November 20, 2013 2:52 PM
Scoop.it!

Les maladies auto-immunes

Les maladies auto-immunes | AUTOIMMUNITY | Scoop.it
Les maladies auto-immunes résultent d'un dysfonctionnement du système immunitaire qui s’attaque aux constituants normaux de l’organisme, ou « auto-antigènes ».

Via Lindzy Tossé
Gilbert C FAURE's insight:

one year old, but still true. (en français)

No comment yet.
Rescooped by Gilbert C FAURE from diabetes and more
November 18, 2013 6:32 AM
Scoop.it!

Clinical Immunology | Vol 149, Iss 3, Part A, Pgs 265-356, (December, 2013) | ScienceDirect.com

The online version of Clinical Immunology at ScienceDirect.com, the world's leading platform for high quality peer-reviewed full-text journals.

Via Ellen H Ullman, MSW
Gilbert C FAURE's insight:

survey of clinical trials focusing on immune pathogenesis

Ellen H Ullman, MSW's curator insight, November 16, 2013 8:52 PM

Current Trials in Type 1 Diabetes

Rescooped by Gilbert C FAURE from Immunology Diagnosis
November 18, 2013 3:17 AM
Scoop.it!

Mass screening for celiac disease : a public health intervention from the participant perspective

Mass screening for celiac disease : a public health intervention from the participant perspective | AUTOIMMUNITY | Scoop.it
Background  Celiac disease (CD) is a chronic disorder in genetically predisposed individuals in which damage to the small intestine is caused by eating foods containing gluten. The prevalence has b ...

Via Alfredo Corell
Gilbert C FAURE's insight:

screening coming ?

Alfredo Corell's curator insight, November 17, 2013 3:56 PM

Author:Nordyke, Katrina (Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health)Title:Mass screening for celiac disease: a public health intervention from the participant perspectiveDepartment:Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health

 

 

 

Conclusions  Our findings suggest that it is possible for participants to avoid excess anxiety during CD screening. However, there was not consensus among participants that being detected and treated had improved their health-related quality of life or that the immediate benefits outweighed the harm caused by being detected in this way. When considering mass screening, the affect on the participants is important to take into account and our findings shed light on some of the potential impacts a CD mass screening could have on participants.

Scooped by Gilbert C FAURE
November 17, 2013 6:54 AM
Scoop.it!

Joint BSPGHAN and Coeliac UK guidelines for the diagnosis and management of coeliac disease in children

Joint BSPGHAN/Coeliac Society Guidelines for the diagnosis and managment of Coeliac disease Open access at
http://t.co/XitU5tstKq …
No comment yet.
Scooped by Gilbert C FAURE
November 16, 2013 7:29 AM
Scoop.it!

Topical treatment for psoriasis targets deeper layers of the skin, improves ... - Science Daily (press release)

Topical treatment for psoriasis targets deeper layers of the skin, improves ... - Science Daily (press release) | AUTOIMMUNITY | Scoop.it
Topical treatment for psoriasis targets deeper layers of the skin, improves ...
No comment yet.