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Eliminating Encephalitogenic T Cells without Undermining Protective Immunity [AUTOIMMUNITY] http://t.co/6dAuta4sh5 #jimmTCB 
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Defective Stromal Remodeling in Lymphoid Tissues Favor the Transition from Autoimmunity to Lymphoma
Gilbert C FAURE's insight:
CD5+ B cells finding their niche?
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Emerging research about autoantibodies in type 1 diabetes is redefining the natural history of this disease, and could lead to new diagnostic criteria.
Gilbert C FAURE's insight:
a major advance for natural history of the disease! relying on autoantibodies and implying early screening of children
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Narcolepsy, a disorder strongly associated with human leukocyte antigen (HLA)–DQA1*01:02/DQB1*06:...
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Lupus Organizations Unite to Stimulate Advances in Lupus Research
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Autoimmunity, seizures, and status epilepticus. Epilepsia 2013 http://t.co/FcFSrcuJ84
Gilbert C FAURE's insight:
already posted in september as pubmed reference see also neurology in this topic http://www.scoop.it/t/autoimmunity?q=neurology
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The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the “omic” composition of the tissue from which it originates in its physiological or pathological signature.
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HUNTSVILLE, AL--(Marketwired - Dec 17, 2013) - Conversant Bio, a global leader in supplying the highest-quality human tissue and viable cell samples, today announced it is publishing a new e-book to provide researchers with a guide to autoimmune...
Gilbert C FAURE's insight:
HUNTSVILLE, AL--(Marketwired - Dec 17, 2013) - Conversant Bio, a global leader in supplying the highest-quality human tissue and viable cell samples, today announced it is publishing a new e-book to provide researchers with a guide to autoimmune disorders. The e-book Researchers Guide to Immunology: From the Real World to the Lab, is available as a free download at http://www.conversantbio.com/researchers-guide-to-immunology-ebook.
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Coeliac disease comprises intolerance against dietary wheat, rye and barley gluten and is one of the most common food-related life-long disorders in Western countries.
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Cell Pouch System - Dramatic Diabetes Breakthrough in 2014?
Gilbert C FAURE's insight:
a survey for layinvestors
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Systemic lupus erythematosus (SLE) is characterized by impaired efferocytosis and aberrant activation of innate immunity.
Gilbert C FAURE's insight:
nice LBT
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Autoimmunity Reviews will publish up-to-date, structured reviews on diverse topics in autoimmunity, written by first-class experts in the field. The... (Buscando artículos para desarrollar el tema.
Gilbert C FAURE's insight:
not a new journal?
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Marker Predicts Poor Outcomes in Scleroderma MedPage Today Patients with systemic sclerosis who had high levels of circulating CXCL4 were more than three times as likely to develop early pulmonary fibrosis as shown by a 30% or more loss in forced...
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Guernsey Press and Star (subscription) Robespierre 'may have had disorder' Guernsey Press and Star (subscription) Careful examination of the wax mask, together with a review of historical medical records, indicated that Robespierre was afflicted by...
Gilbert C FAURE's insight:
a chronic inflammatory granulomatous disease
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The complex interplay between the immune system and cancer -- specifically, an anti-tumor immune response that leads to tissue damage -- may underlie the development of scleroderma, current research s (Tumors May Give Rise to Autoimmunity (CME/CE)...
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Results also partly explain why the 2009 swine flu virus, and a vaccine against it, led to spikes in the sleep disorder.
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A newly identified immune protein influences each person's response to vaccines and risk for autoimmune diseases like lupus and multiple sclerosis.
Gilbert C FAURE's insight:
which one?...press release not so clear in fact FcR! The research team found that people with a genetic variant present in approximately 15 percent of the world population can express an additional immune system receptor on their B cells, the cells that make antibodies. This additional receptor, called an Fc receptor, binds the antibodies made by B cells and plays a key role in regulating their production. Part of the immune system, antibodies can recognize invaders like bacteria and remove them from the body. In individuals with autoimmune diseases, however, they can also attack the body's own cells, causing disease.
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Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. By - Nuria Gresa-Arribas PhD, Maarten J Titulaer MD, Abiguei Torrents BS, Esther Aguilar...
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Belimumab exhibited a satisfactory profile regarding efficacy, safety, and tolerability. Rituximab showed no superiority over placebo in terms of efficacy, despite its suitable safety profile. Biologic agents exhibited a good safety profile for SLE treatment, indicating that these agents are promising therapies and should be further investigated. Via Krishan Maggon
Gilbert C FAURE's insight:
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T-cell tolerance to self-antigens is established in the thymus through the recognition by developing thymocytes of self-peptide-MHC (pMHC) complexes and induced and maintained in the periphery.
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MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of... http://t.co/Qi9dBl3W8y #JEMTCB
Gilbert C FAURE's insight:
j exp med
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Here we report that proliferation of Treg cells after TCR stimulation is impaired in subjects with relapsing-remitting multiple sclerosis (RRMS) because of altered interleukin-2 (IL-2) secretion and IL-2 receptor (IL-2R)-signal ... Via Krishan Maggon , Alfredo Corell
Alfredo Corell's curator insight,
December 13, 2013 12:42 PM
Original article: http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3411.html NATURE MEDICINE | LETTER Regulatory T cell proliferative potential is impaired in human autoimmune diseaseFortunata Carbone,Veronica De Rosa,Pietro B Carrieri,Silvana Montella,Dario Bruzzese,Antonio Porcellini,Claudio Procaccini,Antonio La Cava& Giuseppe Matarese
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Human endogenous retrovirus protein activates innate immunity and promotes experimental… http://t.co/W5aEhhqRN5
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Pore formation in cell membranes linked to triggers of rheumatoid arthritis The Almagest Experiments by scientists at Johns Hopkins and in Boston have unraveled two biological mechanisms as the major cause of protein citrullination in rheumatoid...
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J Immunology