AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
October 4, 2014 3:26 AM
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Brain Antigen-Directed Autoantibodies Found Comparably Detec... : Neurology Today

An abstract is unavailable.
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Scooped by Gilbert C FAURE
September 30, 2014 2:44 PM
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TGF-ß prevents self-reactive B cell activation - HealthCanal.com

TGF-ß prevents self-reactive B cell activation - HealthCanal.com | AUTOIMMUNITY | Scoop.it
TGF-ß prevents self-reactive B cell activation
HealthCanal.com
... at Lyon and member of the German Cancer Research Center (DKFZ), revealed together with his colleague Dr. Mark J.
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Suggested by Société Francaise d'Immunologie
September 30, 2014 2:22 PM
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The Cross-Priming Capacity and Direct Presentation Potential of an Autoantigen Are Separable and Inversely Related Properties [AUTOIMMUNITY]

We investigated whether a prevalent epitope of the β-cell–specific autoantigen islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP206–214) reaches regional Ag-presentation pathways via unprocessed polypeptide chains, as...
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Scooped by Gilbert C FAURE
September 28, 2014 2:13 PM
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Autoimmune Diabetes Is Suppressed by Treatment with Recombinant Human Tissue Kallikrein-1

Autoimmune Diabetes Is Suppressed by Treatment with Recombinant Human Tissue Kallikrein-1 | AUTOIMMUNITY | Scoop.it
by Lilia Maneva-Radicheva, Christina Amatya, Camille Parker, Jacob Ellefson, Ilian Radichev, Arvind Raghavan, Matthew L. Charles, Mark S. Williams, Mark S. Robbins, Alexei Y.
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Scooped by Gilbert C FAURE
September 26, 2014 3:36 PM
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NIH announces network to accelerate medicines for rheumatoid arthritis and lupus - Phys.Org

NIH announces network to accelerate medicines for rheumatoid arthritis and lupus - Phys.Org | AUTOIMMUNITY | Scoop.it
NIH announces network to accelerate medicines for rheumatoid arthritis and lupus
Phys.Org
RA and lupus are relatively common, severe autoimmune diseases.
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Scooped by Gilbert C FAURE
September 24, 2014 2:53 PM
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Associations between thyroid autoantibody status and abnormal pregnancy outcomes in euthyroid women - Online First - Springer

Associations between thyroid autoantibody status and abnormal pregnancy outcomes in euthyroid women - Online First - Springer | AUTOIMMUNITY | Scoop.it
Associations between thyroid autoantibody status and abnormal pregnancy outcomes in euthyroid women: Abstract
... http://t.co/vx76VqYEw2
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Scooped by Gilbert C FAURE
September 23, 2014 1:46 PM
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Methotrexate: an old new drug in autoimmune disease, Expert Review of Clinical Immunology, Informa Healthcare

Methotrexate: an old new drug in autoimmune disease, Expert Review of Clinical Immunology, Informa Healthcare | AUTOIMMUNITY | Scoop.it
Methotrexate: an old new drug in autoimmune disease: Expert Review of Clinical Immunology, Ahead of Print.
http://t.co/H6Jgbn7GXU
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Scooped by Gilbert C FAURE
September 22, 2014 8:24 AM
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Autoantibody profiling in APS. [Lupus. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
September 22, 2014 8:20 AM
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Autoimmunity, phospholipid-reacting antibodies and malaria [Lupus. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
September 21, 2014 2:17 PM
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Researchers Uncover New Insights Into Vascular Receptor Autoantibodies in ... - Pulmonary Hypertension News

Researchers Uncover New Insights Into Vascular Receptor Autoantibodies in ... - Pulmonary Hypertension News | AUTOIMMUNITY | Scoop.it
Pulmonary Hypertension News
Researchers Uncover New Insights Into Vascular Receptor Autoantibodies in ...
Pulmonary Hypertension News
Systemic sclerosis (SSc) is a clinically diverse disease and is considered a multi-organ autoimmune disorder.
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Suggested by Société Francaise d'Immunologie
September 21, 2014 2:14 PM
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Complement Component C5a Permits the Coexistence of Pathogenic Th17 Cells and Type I IFN in Lupus [AUTOIMMUNITY]

Systemic lupus erythematosus (SLE) is a type I IFN (IFN-I)–driven autoimmune disorder with exaggerated B and Th cell responses. Th17 cells, a recently identified Th cell subset, have been strongly implicated in the pathogenesis of SLE.
Krishan Maggon 's curator insight, September 22, 2014 12:56 AM
Published online before printAugust 22, 2014, doi:10.4049/jimmunol.1401322The Journal of ImmunologyOctober 1, 2014vol. 193 no. 7 3288-3295 Complement Component C5a Permits the Coexistence of Pathogenic Th17 Cells and Type I IFN in LupusSudesh Pawaria*, Kritika Ramani*, Kelly Maers*, Youhua Liu†, Lawrence P. Kane‡,Marc C. Levesque* and Partha S. Biswas*

+Author Affiliations

*Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;†Division of Pathology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; and‡Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261Address correspondence and reprint requests to Dr. Partha S. Biswas, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, BST S725, 3500 Terrace Street, Pittsburgh PA 15261. E-mail address: psb13@pitt.edu
Scooped by Gilbert C FAURE
September 18, 2014 10:52 AM
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PLA2R-associated membranous glomerulopathy is modulated by common ... - Nature.com

PLA2R-associated membranous glomerulopathy is modulated by common ...
Gilbert C FAURE's insight:

Membranous glomerulopathy (MG) is most commonly caused by autoantibodies directed against the podocyte phospholipase A2 receptor (PLA2R1) and common variants in this gene are associated with MG. Here for the first time, we carried out a large case–control association study (n=1512) of PLA2R-positive and -negative MG to determine the extent of association in these pathologic subtypes.....

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Scooped by Gilbert C FAURE
September 18, 2014 10:50 AM
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Acid Hydrolysis of Wheat Gluten Induces Formation of New Epitopes but Does Not Enhance Sensitizing Capacity by the Oral Route: A Study in “Gluten Free” Brown Norway Rats

Acid Hydrolysis of Wheat Gluten Induces Formation of New Epitopes but Does Not Enhance Sensitizing Capacity by the Oral Route: A Study in “Gluten Free” Brown Norway Rats | AUTOIMMUNITY | Scoop.it
by Stine Kroghsbo, Nanna B. Andersen, Tina F. Rasmussen, Susanne Jacobsen, Charlotte B. Madsen
Background Acid hydrolyzed wheat proteins (HWPs) are used in the food and cosmetic industry as emulsifiers.
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Rescooped by Gilbert C FAURE from Mucosal Immunity
October 2, 2014 9:31 AM
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Impaired mucosal immunity in patients with SLE - Nature.com

Impaired mucosal immunity in patients with SLE
Nature.com
In turn, microbial infections have been implicated as environmental factors that can influence autoimmune diseases in genetically predisposed individuals.
Gilbert C FAURE's curator insight, October 2, 2014 9:32 AM

A new study published this week in The Journal of Immunology identifies deficiencies in mucosal-associated invariant T (MAIT) cells from patients with systemic lupus erythematosus (SLE).

MAIT cells have an important function in mucosal immunity by protecting against mycobacterial and enterobacterial infections. In turn, microbial infections have been implicated as environmental…

  
Scooped by Gilbert C FAURE
September 30, 2014 2:34 PM
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Intersection of population variation and autoimmunity genetics in human T cell activation

Two articles next to each other in @sciencemagazine relating to autoimmunity. http://t.co/iHrL7HzfAA & http://t.co/ajP0k8U2mI Interesting.
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Scooped by Gilbert C FAURE
September 28, 2014 2:39 PM
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Protecting the Body from Itself

Protecting the Body from Itself | AUTOIMMUNITY | Scoop.it
SINGAPORE, Sept 26, 2014 - (ACN Newswire) - Scientists from A*STAR's Bioprocessing Technology Institute (BTI) have established a clearer relationship (Autoimmune Research in the News: Protecting the Body from Itself - #immunology

#NKTCells...
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Scooped by Gilbert C FAURE
September 28, 2014 2:08 PM
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Different IVIG Glycoforms Affect In Vitro Inhibition of Anti-Ganglioside Antibody-Mediated Complement Deposition

Different IVIG Glycoforms Affect In Vitro Inhibition of Anti-Ganglioside Antibody-Mediated Complement Deposition | AUTOIMMUNITY | Scoop.it
by Makoto Sudo, Yoshiki Yamaguchi, Peter J. Späth, Kana Matsumoto-Morita, Benjamin K.
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Scooped by Gilbert C FAURE
September 26, 2014 3:33 PM
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Scientists advance understanding of autoimmunity with discovery of link between major immune cell types

Scientists advance understanding of autoimmunity with discovery of link between major immune cell types | AUTOIMMUNITY | Scoop.it
Scientists from A*STAR's Bioprocessing Technology Institute (BTI) have established a clearer relationship between two cells which serve our body's natural defence mechanisms against diseases and infections.
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Scooped by Gilbert C FAURE
September 23, 2014 2:39 PM
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Diminutive decoys: Membrane-cloaked nanoparticles disrupt antibody-mediated autoimmune diseases

Diminutive decoys: Membrane-cloaked nanoparticles disrupt antibody-mediated autoimmune diseases | AUTOIMMUNITY | Scoop.it
(Medical Xpress)—What do rheumatoid arthritis, type I diabetes, myasthenia gravis, multiple sclerosis, rheumatic heart disease, and narcolepsy have in common?
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Scooped by Gilbert C FAURE
September 22, 2014 1:29 PM
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Highlighted article - September - Clinical Immunology - Elsevier

Highlighted article - September - Clinical Immunology - Elsevier | AUTOIMMUNITY | Scoop.it
Interferon alpha on NZM2328.Lc1R27: Enhancing autoimmunity and immune complex-mediated glomerulonephritis without end stage renal failure

Chao... (RT @ImmunologyNews: Highlighted article about Interferon alpha on NZM2328.Lc1R27 - Read for free!
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Scooped by Gilbert C FAURE
September 22, 2014 8:23 AM
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Immunologic derangement preceding clinical autoimmunity. [Lupus. 2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Gilbert C FAURE's insight:

Over the last 25 years, several investigators have consistently shown that autoantibodies precede the clinical onset of cognate diseases by years or decades. This phenomenon, regularly observed in the natural history of autoimmune diseases, indicates that autoimmunity develops through successive stages across a variable period of time until the characteristic manifestations of disease are clinically apparent.

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Scooped by Gilbert C FAURE
September 21, 2014 2:18 PM
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Eli Lilly v Human Genome Sciences Ltd - Lexology (registration)

Eli Lilly v Human Genome Sciences Ltd - Lexology (registration) | AUTOIMMUNITY | Scoop.it
Eli Lilly v Human Genome Sciences Ltd
Lexology (registration)
HGS have received marketing approval in Europe for a belimumab-containing product (BENLYSTA®) for the treatment of active, autoantibody-positive systemic lupus erythematosus (SLE).
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Scooped by Gilbert C FAURE
September 21, 2014 2:16 PM
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The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production: Immunity

On the cover: Amino acid transporter SLC15A4 controls TLR7-induced autoantibody production http://t.co/YW4g1TZXsh http://t.co/QHjJn73oV8
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Suggested by Société Francaise d'Immunologie
September 21, 2014 2:14 PM
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Fungal {beta}-Glucan, a Dectin-1 Ligand, Promotes Protection from Type 1 Diabetes by Inducing Regulatory Innate Immune Response [AUTOIMMUNITY]

β-Glucans are naturally occurring polysaccharides in cereal grains, mushrooms, algae, or microbes, including bacteria, fungi, and yeast. Immune cells recognize these β-glucans through a cell surface pathogen recognition receptor called Dectin-1.
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Scooped by Gilbert C FAURE
September 18, 2014 10:51 AM
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Enterovirus RNA in longitudinal blood samples and risk of islet autoimmunity in children with a high genetic risk of type 1 diabetes: the MIDIA study

Enterovirus RNA in longitudinal blood samples and risk of islet autoimmunity in children with a high genetic risk of type 1 diabetes: the MIDIA study | AUTOIMMUNITY | Scoop.it
Endocrinology Medical Article: Enterovirus RNA in longitudinal blood samples and risk of islet autoimmunity in children with a high genetic risk of type 1 diabetes: the MIDIA study (Enterovirus RNA in longitudinal blood samples and risk of islet...
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