AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
January 17, 2015 2:13 PM
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Anti IFN-gamma autoantibody associated with adult-onset immunodeficiency

Anti IFN-gamma autoantibody associated with adult-onset immunodeficiency | AUTOIMMUNITY | Scoop.it
Anti IFN-gamma autoantibody associated with adult-onset immunodeficiency

Presented by Suda Punrin, MD.
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Scooped by Gilbert C FAURE
January 17, 2015 2:11 PM
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FCRL3 Gene Polymorphisms Confer Autoimmunity Risk for Allergic Rhinitis in a Chinese Han Population

FCRL3 Gene Polymorphisms Confer Autoimmunity Risk for Allergic Rhinitis in a Chinese Han Population | AUTOIMMUNITY | Scoop.it
by Zheng Gu, Su-Ling Hong, Xia Ke, Yang Shen, Xiao-Qiang Wang, Di Hu, Guo-Hua Hu, Hou-Yong Kang
Background Heredity and environmental exposures may contribute to a predisposition to allergic rhinitis (AR).
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Scooped by Gilbert C FAURE
January 16, 2015 2:25 PM
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Steering stem cell trafficking into pancreas reverses type 1 diabetes - Harvard Gazette

Steering stem cell trafficking into pancreas reverses type 1 diabetes - Harvard Gazette | AUTOIMMUNITY | Scoop.it
Harvard researchers at Brigham and Women’s Hospital have uncovered a way to enhance and prolong the therapeutic effects of mesenchymal stem cells in a preclinical model of type 1 diabetes.
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Scooped by Gilbert C FAURE
January 14, 2015 1:44 PM
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Recurrent polymyositis-associated lung disease after lung transplan... - PubMed - NCBI

Interact Cardiovasc Thorac Surg. 2015 Jan 7. pii: ivu423. [Epub ahead of print]
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Scooped by Gilbert C FAURE
January 14, 2015 1:24 PM
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Decrease in Circulating Concentrations of Soluble Receptors for Advanced Glycation End Products at the Time of Seroconversion to Autoantibody Positivity in Prediabetic Children.

Decrease in Circulating Concentrations of Soluble Receptors for Advanced Glycation End Products at the Time of Seroconversion to Autoantibody Positivity in Prediabetic Children. | AUTOIMMUNITY | Scoop.it
Authors: Kirsi M Salonen, Samppa J Ryhänen, Josephine M Forbes, Danielle J Borg, Taina Härkönen, Jorma Ilonen, Olli Simell, Riitta Veijola, Per-Henrik Groop, Mikael Knip, Discipline: Medicine, Type: Journal Article...
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Scooped by Gilbert C FAURE
January 13, 2015 2:08 PM
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Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that ... - Nature.com

Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that ...
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Rescooped by Gilbert C FAURE from diabetes and more
January 12, 2015 9:17 AM
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LJI researcher awarded $1.6 million grant to study factors that trigger onset of type 1 diabetes

The American Diabetes Association has awarded La Jolla Institute researcher Stephanie Stanford, Ph.D., a $1.6 million grant to investigate the genetic and environmental factors that trigger the onset of type 1 diabetes.

Via Ellen H Ullman, MSW
Gilbert C FAURE's insight:


PTPN22 http://www.ncbi.nlm.nih.gov/gene/26191

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

 

"We believe that when the PTPN22 gene is mutated, it impairs the body's immune response to viral infections, especially a specific enterovirus that is known to trigger type 1 diabetes by leaving the body vulnerable to an attack on the pancreas," Dr. Stanford said. "We also believe that certain environmental factors, including exposure to pathogens early in life, contribute to increased risk of type 1 diabetes."

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Scooped by Gilbert C FAURE
January 9, 2015 2:41 PM
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Method Identifies Elusive Antigens - The Biological SCENE

Method Identifies Elusive Antigens - The Biological SCENE | AUTOIMMUNITY | Scoop.it
Method Identifies Elusive Antigens
The Biological SCENE
In autoimmune diseases, a person's immune system goes awry, developing antibodies to attack native proteins rather than foreign invaders.
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Scooped by Gilbert C FAURE
January 8, 2015 2:12 PM
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Celiac Disease Can be Predicted by High Levels of Anti-Tissue Trans... - PubMed - NCBI

J Pediatr Gastroenterol Nutr. 2015 Jan 2. [Epub ahead of print]
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Scooped by Gilbert C FAURE
January 7, 2015 2:37 PM
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Public Release: 5-Jan-2015 New study challenges link between HLA class I ... - EurekAlert (press release)

Public Release: 5-Jan-2015 New study challenges link between HLA class I ... - EurekAlert (press release) | AUTOIMMUNITY | Scoop.it
Investigators have suggested that HLA hyperexpression may be an important first step in the development of type 1 diabetes.
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Scooped by Gilbert C FAURE
January 7, 2015 2:06 AM
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The role of T and B cells in human atherosclerosis and atherothrombosis - Ammirati - 2015 - Clinical & Experimental Immunology - Wiley Online Library

The role of T and B cells in human atherosclerosis and atherothrombosis - Ammirati - 2015 - Clinical & Experimental Immunology - Wiley Online Library | AUTOIMMUNITY | Scoop.it
The role of T and B cells in human atherosclerosis and atherothrombosis Ammirati Clinical & Experimental Immunology http://t.co/v7dumv5yLr
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Scooped by Gilbert C FAURE
January 6, 2015 3:57 PM
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Patients with common variable immune deficiency at risk for development of autoimmunity

Patients with common variable immune deficiency at risk for development of autoimmunity | AUTOIMMUNITY | Scoop.it
Common variable immune deficiency (CVID) is a genetic disease associated with enhanced susceptibility to infection, autoimmunity, and decreased antibody production.
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Suggested by Société Francaise d'Immunologie
January 6, 2015 3:54 PM
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Natural Anti-Intestinal Goblet Cell Autoantibody Production from Marginal Zone B Cells [IMMUNE SYSTEM DEVELOPMENT]

Expression of a germline VH3609/D/JH2 IgH in mice results in the generation of B1 B cells with anti-thymocyte/Thy-1 glycoprotein autoreactivity by coexpression of Vk21-5/Jk2 L chain leading to production of serum IgM natural autoantibody.
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Scooped by Gilbert C FAURE
January 17, 2015 2:12 PM
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Autoimmune hepatitis in the Alaska Native population: autoantibody profile and HLA associations.

Autoimmune hepatitis in the Alaska Native population: autoantibody profile and HLA associations. | AUTOIMMUNITY | Scoop.it
Autoimmune hepatitis in the Alaska Native population: autoantibody profile and HLA associations. http://t.co/pzju7glOI3
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Scooped by Gilbert C FAURE
January 17, 2015 2:05 PM
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Dynamic Ocular Surface and Lacrimal Gland Changes Induced in Experimental Murine Dry Eye

Dynamic Ocular Surface and Lacrimal Gland Changes Induced in Experimental Murine Dry Eye | AUTOIMMUNITY | Scoop.it
by Bing Xiao, Yu Wang, Peter S. Reinach, Yueping Ren, Jinyang Li, Shanshan Hua, Huihui Lu, Wei Chen Dry eye disease can be a consequence of lacrimal gland insufficiency in Sjögren’s Syndrome or increased tear film evaporation despite normal...
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Scooped by Gilbert C FAURE
January 15, 2015 3:46 PM
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If helper T cells have nothing to help, they kill their host

If helper T cells have nothing to help, they kill their host | AUTOIMMUNITY | Scoop.it
That's some help.
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Scooped by Gilbert C FAURE
January 14, 2015 1:25 PM
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Neuromuscular junction as Achilles' heel: Yet another autoantibody?

Neuromuscular junction as Achilles' heel: Yet another autoantibody? | AUTOIMMUNITY | Scoop.it
Neuromuscular junction as Achilles' heel: Yet another autoantibody? http://t.co/AdwEEvTyjB
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Scooped by Gilbert C FAURE
January 14, 2015 1:21 PM
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Autoimmune Diseases Masquerading as Psychiatric Disorders- A Paradigm Shift in Psychiatry

Autoimmune Diseases Masquerading as Psychiatric Disorders- A Paradigm Shift in Psychiatry | AUTOIMMUNITY | Scoop.it
Autoimmune diseases result in the production of antibodies that can attack the brain to produce psychiatric symptoms. It is important to diagnose these disorders accurately.
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Scooped by Gilbert C FAURE
January 12, 2015 1:17 PM
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Association of the autoimmune disease scleroderma with an immunolog... - PubMed - NCBI

Science. 2014 Jan 10;343(6167):152-7. doi: 10.1126/science.1246886. Epub 2013 Dec 5. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Scooped by Gilbert C FAURE
January 11, 2015 2:58 PM
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RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells

Interactomic inhibition of transcription factor [Immunology and Inflammation] http://t.co/rHwTHySRog
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Scooped by Gilbert C FAURE
January 8, 2015 3:00 PM
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T cells recognizing a 11mer influenza peptide complexed to H-2D b show ... - Nature.com

T cells recognizing a 11mer influenza peptide complexed to H-2D b show ...
Nature.com
TCR promiscuity has been attributed to various autoimmune conditions.
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Scooped by Gilbert C FAURE
January 8, 2015 1:57 PM
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Natural IgM anti-leucocyte autoantibodies (IgM-ALA) regulate inflammation induced by innate and adaptive immune mechanisms. - Global Medical Discovery

Natural IgM anti-leucocyte autoantibodies (IgM-ALA) regulate inflammation induced by innate and adaptive immune mechanisms. - Global Medical Discovery | AUTOIMMUNITY | Scoop.it
Natural IgM anti-leucocyte autoantibodies (IgM-ALA) regulate inflammation induced by innate immunity via @cpa61 http://t.co/0dNs0Krt3y
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Scooped by Gilbert C FAURE
January 7, 2015 5:06 AM
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JCI - Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

RT @jclinicalinvest: Chronic low level DNA damage promotes systemic autoimmunity http://t.co/nqIqCr50OM
#ResearchArticle #Immunology http:/…
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Scooped by Gilbert C FAURE
January 6, 2015 3:58 PM
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Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients - ...

Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients - ... | AUTOIMMUNITY | Scoop.it
Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant... http://t.co/3Ayt628Gym
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Scooped by Gilbert C FAURE
January 6, 2015 3:55 PM
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UKE Scientists Detect New Autoantibody

UKE Scientists Detect New Autoantibody | AUTOIMMUNITY | Scoop.it
Discovery may put an end to dialysis. Co-operation of UKE with scientists from France and the U.S.
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