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Scooped by
Gilbert C FAURE
April 19, 2022 3:19 AM
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Background SLE is a complex disease characterized by autoimmunity towards apoptotic cells, excessive amounts of circulating immune complexes and complement activation. Decreased platelet size has been observed in SLE and their non-hemostatic functions may play an active role in the disease.
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Scooped by
Gilbert C FAURE
April 19, 2022 3:17 AM
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Glycans constitute basic cellular components of living organisms across biological kingdoms (), and glycan-binding antibodies participate in many cellular interactions during immune defense against pathogenic organisms ().
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Scooped by
Gilbert C FAURE
April 19, 2022 3:14 AM
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Celiac disease (CD) is an autoimmune intestinal disease caused by intolerance of genetically susceptible individuals after intake of gluten-containing grains (including wheat, barley, etc.) and the...
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Scooped by
Gilbert C FAURE
April 14, 2022 3:30 AM
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Testing for liver-related autoantibodies should be included in the workup of patients with hepatitis or cholestasis of unknown origin. Although most of these autoantibodies are not disease specific, their determination is a prerequisite to diagnose autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC), and they are components of the diagnostic scoring system in these diseases. In primary sclerosing cholangitis (PSC), on the other hand, autoantibodies are frequently present but play a minor role in establishing the diagnosis. In PSC, however, data on antibodies suggest a link between disease pathogenesis and the intestinal microbiota. This review will focus on practical aspects of antibody testing in the three major autoimmune liver diseases AIH, PBC, and PSC.
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Scooped by
Gilbert C FAURE
April 11, 2022 12:08 PM
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This article discusses the current understanding of the genetics of autoimmune Addison disease and outlines the autoimmune mechanisms that could underlie the effects on the adrenal cortex.
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Scooped by
Gilbert C FAURE
April 8, 2022 8:07 AM
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New classification criteria for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis endorsed by ACR and EULAR reflect important developments in the field since the 1990 criteria were published, including bringing ANCA testing to the fore.
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Scooped by
Gilbert C FAURE
April 2, 2022 5:14 AM
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Patients with five major AIDs in China had an increased risk of developing cancer, with a predominance in women and younger patients, although cancer incidence, predilection sites and cancer onset time may vary greatly in each AID entity.
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Scooped by
Gilbert C FAURE
March 23, 2022 2:39 PM
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Human autoantibodies neutralizing specific cytokines can underlie specific infectious diseases in otherwise healthy patients. The autoantibodies mimic inborn er
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Scooped by
Gilbert C FAURE
March 16, 2022 7:27 AM
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Roseolovirus infection disrupts how the body trains immune cells not to attack itself, a mouse study shows.
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Scooped by
Gilbert C FAURE
March 4, 2022 2:34 AM
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Post-COVID syndrome is characterized by the persistence of latent autoimmunity up to 11 months after recovery. This phenomenon could be driven by a persistent p
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Scooped by
Gilbert C FAURE
February 19, 2022 10:45 AM
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Pemphigus represents a group of rare and severe autoimmune intra-epidermal blistering diseases affecting the skin and mucous membranes. These painful and debilitating diseases are driven by the production of autoantibodies that are mainly directed against the desmosomal adhesion proteins,...
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Scooped by
Gilbert C FAURE
February 17, 2022 2:27 PM
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Objective To describe the baseline characteristics of patients with positivity for antiphospholipid antibodies (aPLs) who were enrolled in an international registry, the Antiphospholipid Syndrome (...
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Scooped by
Gilbert C FAURE
February 17, 2022 2:23 PM
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BackgroundThat Epstein–Barr virus (EBV) infection is associated with systemic lupus erythematosus (SLE) is established. The challenge is to explain mechanistic roles EBV has in SLE pathogenesis. Previous studies identify four examples of autoantibody cross-reactions between SLE autoantigens and...
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Scooped by
Gilbert C FAURE
April 19, 2022 3:18 AM
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Interleukin-35 (IL-35) is a lately observed cytokine and is part of the IL-12 cytokine family.IL-35 includes two subunits, p35 and Epstein-Barr virus-induced gene 3, and activates subsequent signaling pathways by binding to receptors to mediate signal transduction, thereby modulating the immunoregu...
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Scooped by
Gilbert C FAURE
April 19, 2022 3:15 AM
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Information on a number of conditions that are associated with diabetes including coeliac disease, thyroid disease and dental health complications.
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Scooped by
Gilbert C FAURE
April 15, 2022 4:31 AM
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STAR (Sjögren’s Tool for Assessing Response), a new composite responder index was developed by the NECESSITY Project International Consortium to asse
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Scooped by
Gilbert C FAURE
April 11, 2022 2:04 PM
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Immunoglobulin A (IgA) is generally considered as a non-inflammatory regulator of mucosal immunity, and its importance in diversifying the gut microbiota is increasingly appreciated.IgA autoantibodies have been found in several autoimmune or chronic inflammatory diseases, but their role in pathophy...
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Scooped by
Gilbert C FAURE
April 11, 2022 11:39 AM
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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), characterized by the presence of autoantibodies to neutrophil cytoplasmic antigens, proteinase 3 (PR3), and myeloperoxidase (MPO...
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Scooped by
Gilbert C FAURE
April 6, 2022 11:27 AM
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Le syndrome des antiphospholipides (SAPL) est une entité clinico-biologique définie par l’association de manifestations thrombotiques et/ou de complications obstétricales avec la présence persistante d’anticorps antiphospholipides (aPLs) détectés soit par des tests de coagulation (lupus anticoagulant, LA) soit par des tests immunologiques (anticorps anti-cardiolipine et anticorps anti-β2-glycoprotéine-I). L’essor des anticoagulants oraux directs (AOD) dans la prise […]
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Scooped by
Gilbert C FAURE
March 31, 2022 12:03 PM
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An abstract is unavailable.
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Scooped by
Gilbert C FAURE
March 17, 2022 5:37 AM
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Autoimmunity has emerged as a characteristic of the post-COVID syndrome (PCS), which may be related to sex. In order to further investigate the relationship between SARS-CoV-2 and autoimmunity in PCS, a clinical and serological assessment on 100 patients was done. Serum antibody profiles against self-antigens and infectious agents were evaluated by an antigen array chip for 116 IgG and 104 IgM antibodies. Thirty pre-pandemic healthy individuals were included as a control group. The median age of patients was 49 years (IQR: 37.8 to 55.3). There were 47 males. The median post-COVID time was 219 (IQR: 143 to 258) days. Latent autoimmunity and polyautoimmunity were found in 83% and 62% of patients, respectively. Three patients developed an overt autoimmune disease. IgG antibodies against IL-2, CD8B, and thyroglobulin were found in more than 10% of the patients. Other IgG autoantibodies, such as anti-interferons, were positive in 5–10% of patients. Anti-SARS-CoV-2 IgG antibodies were found in > 85% of patients and were positively correlated with autoantibodies, age, and body mass index (BMI). Few autoantibodies were influenced by age and BMI. There was no effect of gender on the over- or under-expression of autoantibodies. IgG anti-IFN-λ antibodies were associated with the persistence of respiratory symptoms. In summary, autoimmunity is characteristic of PCS, and latent autoimmunity correlates with humoral response to SARS-CoV-2.
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Scooped by
Gilbert C FAURE
March 4, 2022 7:59 AM
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Scooped by
Gilbert C FAURE
February 25, 2022 1:03 PM
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Autoantibodies that neutralize type I interferons increase with age
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Scooped by
Gilbert C FAURE
February 17, 2022 2:28 PM
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Autoimmune encephalitis (AIE) is a group of immune-mediated inflammatory processes of the brain with marked psychiatric features. Although relatively rare, they might offer difficult differential d...
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Scooped by
Gilbert C FAURE
February 17, 2022 2:25 PM
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Researchers found circulating antiphospholipid antibodies, which can be more common among people with autoimmune disorders.
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