Futurity.org – These molecules make memories stick around | Metaglossia: The Translation World | Scoop.it
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U. PENNSYLVANIA (US) — Scientists have identified key molecules that help convert short-term memories into long-term ones.

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The finding comes close to answering the question: how does an experience become a memory that can be accessed months, even years later?
These molecules may offer a target for drugs that can enhance memory, alleviating some of the cognitive symptoms that characterize conditions such as schizophrenia, depression, and Parkinson’s and Alzheimer’s diseases.
“There are many drugs available to treat some of the symptoms of diseases like schizophrenia,” says Ted Abel, a biology professor at the University of Pennsylvania, “but they don’t treat the cognitive deficits that patients have, which can include difficulties with memory. This study looks for more specific targets to treat deficits in cognition.”
Published in the Journal of Clinical Investigation, the study focused on a group of proteins called nuclear receptors, which have been implicated in the regulation of a variety of biological functions, including memory formation.
Nuclear receptors are a kind of transcription factor, proteins that can bind to DNA and regulate the activity of other genes. Their regulatory role may be significant in memory formation, as gene transcription is required to turn short-term memories into long-lasting ones by strengthening neuronal synapses in the brain.

Mice memories
To identify how this class of transcription factors figures in memory formation, the research team trained mice using a common method to create memories of a place and event, in which animals learn to associate a particular context or a certain tone with a specific experience.
Associations with a place or context are believed to be encoded in the hippocampus, while memories associated with a cue such as a tone are believed to be encoded in the amygdala.