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Metastatic breast cancer cells evade the brain's defences by evolving characteristics unique to neurons and co-opting their energy source (A new study may reveal how breast cancer cells can spread to the brain and thrive: 
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Although optic neuritis (ON) is a defining feature of neuromyelitis optica (NMO), appropriate animal models of NMO ON are lacking. Most NMO patients are seropositive for immunoglobulin G autoantibodies (NMO-IgG) against ...
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DUBLIN, Ireland, January 29, 2014 /PRNewswire/ --Research and Markets... (Glioblastoma News: ImmunoCellular Therapeutics' ICT-107 - Is 2013 the year of glioblastoma vaccines - PR Newsw...
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Read the latest recommendation by Alfredo Berardelli, Antonio Suppa and Daniele Belvisi from the Neurological Disorders Faculty, at F1000Prime. (Cerebrospinal fluid lysosomal enzymes and α-synuclein in Parkinson's disease.
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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ImmunoCellular Therapeutics' ICT-107 - Is 2013 the year of glioblastoma vaccines PR Newswire (press release) In this report we discuss whether the evidence of antitumor activity is real, whether historical comparisons provide an accurate...
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. Via Krishan Maggon
Gilbert C FAURE's insight:
multiple sclerosis
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The neuroepithelia of the choroid plexus (CP) in the brain and the ciliary body (CB) of the eye have common embryological origins and share similar micro-structure and functions.
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. Via Krishan Maggon
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Daclizumab is a humanized monoclonal antibody of the immunoglobulin G1 (IgG1) isotype that binds to the α-subunit (CD25) of the high-affinity interleukin-2 (IL-2) receptor expressed on activated T cells and CD4+CD25+FoxP3+ regulatory T cells. It would block the activation and expansion of autoreactive T cells that are central to the immune pathogenesis of multiple sclerosis (MS), daclizumab was tested in several small open-label clinical trials in MS and demonstrated a profound inhibition of inflammatory disease activity. The most important biological effect of daclizumab was a dramatic expansion and activation of immunoregulatory CD56bright natural-killer (NK) cells that correlated with treatment response, while there was no or only minor effect on peripheral T-cell activation and function. These CD56bright NK cells were able to gain access to the central nervous system in MS and kill autologous activated T cells. Additional and relatively large phase IIb clinical trials showed that daclizumab, as add-on or monotherapy in relapsing–remitting (RR) MS, was highly effective in reducing relapse rate, disability progression, and the number and volume of gadolinium-enhancing, T1 and T2 lesions on brain magnetic resonance imaging (MRI), and reproduced the expansion of CD56bright NK cells as a biomarker for daclizumab activity. Daclizumab is generally very well tolerated and has shown a favorable adverse event (AE) profile in transplant recipients. However, several potentially serious and newly emerging AEs (mainly infections, skin reactions, elevated liver function tests and autoimmune phenomena in several body organs) may require strict safety monitoring programs in future clinical practice and place daclizumab together with other new and highly effective MS drugs as a second-line therapy. Ongoing phase III clinical trials in RRMS are expected to provide definite information on the efficacy and safety of daclizumab and to determine its place in the fast-growing armamentarium of MS therapies. Via Krishan Maggon
Krishan Maggon 's curator insight,
January 27, 2014 2:42 AM
A very good review about the safety and efficacy of daclizumab
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2 Minute Medicine
Gilbert C FAURE's insight:
links to NEJM and Janssen
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RT @NatureRevCancer: NEW Review: Genomic & epigenomic culprits in glioblastoma emerge: http://t.co/nfEMYntTC3
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News, analysis and in-depth coverage for food safety and quality professionals implementing science-based food safety strategies and systems throughout the supply chain.
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PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
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Senescent changes in cerebrospinal fluid circulatory physiology and their role in the pathogenesis of NTG http://t.co/3Qa9vrUp0D
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Dr. Hans-Christoph Diener revisits advances in neurology from 2013 that you should not miss.
Gilbert C FAURE's insight:
medscape multispecialty , from Essen
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Neurology Grand Rounds SEPT 25 2013 Neuroimmunology Division Enrique Alvarez, MD, PhD Assistant Professor of Neurology.
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Guardian Liberty Voice Bacterial toxin may trigger multiple sclerosis, research finds Fox News Multiple sclerosis (MS), a central nervous system disease that often leads to paralysis and vision problems, affects approximately 2.3 million people...
Gilbert C FAURE's insight:
dans les medias
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Tweet TweetDuring this month, eight cases of Naegleria fowleri have been reported in Karachi, Pakistan. Naegleria causes acute Primary Amoebic Meningoencephalitis (PAM) which is a fatal disease of brain.
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#ChoroidPlexusTumors - Normal choroid plexus (left), Choroid Plexus Papilloma (middle), and Choroid Plexus Carcinoma (right). Additional images are on...
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Gilbert C FAURE's insight:
in another life, studied a lot CP in AD and found DCs in epithelium
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Gene expression-based comparison of the human secretory neuroepithelia of ...
Gilbert C FAURE's insight:
choroid plexuses
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This 2014 FASEB Science Research Conference focuses on recent advances in our understanding of the neuroimmune axis and its role in disease processes.
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