Authors: Nikolaos A Patsopoulos, Lisa F Barcellos, Rogier Q Hintzen, Catherine Schaefer, Cornelia M van Duijn, Janelle A Noble, Towfique Raj, Pierre-Antoine Gourraud, Barbara E Stranger, Jorge Oksenberg, Tomas Olsson, Bruce V Taylor, Stephen...
from JAMA Neurology — Immunophenotyping of Cerebrospinal Fluid Cells in Multiple Sclerosis — In Search of Biomarkers (RT @JAMANeuro: Immunophenotyping of Cerebrospinal Fluid Cells in Multiple Sclerosis In Search of Biomarkers
Immunophenotyping of Cerebrospinal Fluid Cells in Multiple SclerosisIn Search of Biomarkers ONLINE FIRSTSascha Alvermann, MD1; Christian Hennig, MD2; Olaf Stüve, MD, PhD3,4; Heinz Wiendl, MD5; Martin Stangel, MD1[+] Author AffiliationsJAMA Neurol. Published online May 12, 2014. doi:10.1001/jamaneurol.2014.395
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates through the ventricles, the cisterns, and the subarachnoid space to be absorbed into the blood by...
Amyloid levels in the brain are very dynamic, capable of changing rapidly. That amyloid builds up with age to contribute to the development of neurodegenerative conditions such as Alzheimer's disease...
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
Acrylamide exposure impairs blood-cerebrospinal fluid barrier function Nanotechnology News (press release) The blood-brain barrier prevents xenobiotics from entering the central nervous system.
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The gene that controls blood-brain barrier permeability through a little-studied phenomenon calledtranscytosis has been identified by researchers for the first time.
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Effects of UVB light were analyzed in a murine model of CNS autoimmunity (experimental autoimmune encephalomyelitis (EAE)). Additionally, patients with relapsing-remitting MS were treated with narrowband UVB phototherapy. Immunomodulatory effects were examined in skin biopsies, serum samples and in immune cells of the peripheral blood
Local UVB radiation of the skin influences systemic immune reactions and attenuates systemic autoimmunity via the induction of skin-derived tolerogenic DCs and Tregs. Our data could have implications for the understanding or therapeutic modulation of environmental factors which influence immune tolerance. ANN NEUROL 2014
by Kasandra Burgos, Ivana Malenica, Raghu Metpally, Amanda Courtright, Benjamin Rakela, Thomas Beach, Holly Shill, Charles Adler, Marwan Sabbagh, Stephen Villa, Waibhav Tembe, David Craig, Kendall Van Keuren-Jensen The discovery and reliable...
This study provides evidence in humans for a circadian IL-6 rhythm in CSF and confirms prior observations reporting a plasma biphasic circadian pattern. Our results indicate differential IL-6 regulation across the two compartments and are consistent with local production of IL-6 in the CNS. Possible physiological significance is discussed and implications for further research are highlighted.
Research in Howard Weiners laboratory at Brigham & Womens Hospital in Boston supported by a Transformational R01 Grant Role of the innate immune system in aging and the development of Alzheimers...
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