Köck et al. report the use of interproton distances from ROESY spectra as restraints in a computational approach (fc-rDG/DDD method) in order to determine relative configuration of dimeric pyrrole–imidazole alkaloids.
Natural Products Chemistry Breaking News
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A recompilation of news and links about natural products, organic chemistry and science more generally ...
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Ben Chen et al described in Organic Letters Neaumycin, a new 30-membered macrolide featuring an internal diester bridge, a molecular architecture that is unprecedented among known macrolide natural products 
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In the hunt for drugs that target diseases in the developing world, ‘open innovation’ is creating a buzz. Pharmaceutical companies are making entire libraries of chemical compounds publicly available, allowing researchers to rifle through them for promising drug candidates.
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Tanigushi & Monde present the Exciton Chirality method applied to Vibrational Circular Dichroism.
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Everyone who's done drug discovery has encountered this situation: you get what looks like a hit in a screening assay, but when you re-check it with fresh material, it turns out to be inactive. Derek Lowe (blog "In the pipeline") discuss the subject. Paper in question is here http://pubs.acs.org/doi/abs/10.1021/ml200204m
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A series of ferrocenyl taxoids were prepared by acylation of paclitaxel and docetaxel with
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Jon Chui is an incredibly talented person (follow some article of is blog and you'll undersatnd) Here he delivers us a very didactic bird’s eye view of 1H NMR spectra interpretation in comic form.
A resolution-independent PDF is available here : http://www.jkwchui.com/WP/wp-content/uploads/2011/12/InterpretingNMR_r4_overview1.pdf
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Discovery of a novel antimalarial agent using phenotypic screening of Plasmodium falciparum asexual blood-stage parasites. Screening a novel compound collection created using diversity-oriented synthesis (DOS) led to the initial hit. Structure–activity relationships guided the synthesis of compounds having improved potency and water solubility, yielding a subnanomolar inhibitor of parasite asexual blood-stage growth.
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The latest famous Newmann & Cragg's review on natural products as source of new drugs is available at JNP.
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As almost every scientist knows, a person's first year in research is an emotional minefield. One minute you're flying high. The next, you're banging your head against the wall, resisting the urge to draw in results with a marker pen. Forget the F-word; in science, it's the O-word that generates dread. I sometimes think that 'optimizing' should be spelled 'r.e.p.e.a.t.e.d.f.a.i.l.u.r.e.s'.
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Everything you need to know about ACTA.... Ok, this is not about natural products in particular but more about knowledge sharing and it does concerns us !!!
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NASA-funded researchers have evidence that some building blocks of DNA, the molecule that carries the genetic instructions for life, found in meteorites were likely created in space.
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Pauli's team dicuss about the utility of quantitative 1H NMR spectroscopy (qNMR) to generate precise fingerprints of botanical species in complex mictures.
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The aim of this study was to identify antioxidants from Garcinia buchananii bark extract using hydrogen peroxide scavenging and oxygen radical absorbance capacity (ORAC) assays. LC-MS/MS analysis, 1D- and 2D-NMR, and circular dichroism (CD) spectroscopy led to the unequivocal identification of the major antioxidative molecules as a series of three 3,8″-linked biflavanones and two flavanone-C-glycosides.
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Beniddir et al. from ICSN desribed in EurJOC the serendipitous discovery of the antiprotozoal activity of diarylheptanoids derivatives an their (not serendipitous) absolute configuration determination via the Exciton Chirality method.
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Zimmermann et al. in Switzerland, identified cynaropicrin, a sesquiterpene lactone, as the first natural product with notable in vivo anti-trypanosomal activity.
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And now the TLC version ...
High-res pdf is available here : http://www.jkwchui.com/WP/wp-content/uploads/2011/12/TLC-R3.pdf
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Kim et al. published about a small-molecule-based method to induce dedifferentiation in mammalian skeletal muscle. This is the first demonstration of a small molecule method that induces mammalian muscle to undergo dedifferentiation and rededifferentiation into alternate cell lineages. This method induces dedifferentiation in a simple, stepwise approach and has therapeutic potential to enhance tissue regeneration in mammals.
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Kumar et al. describe in MedChemComm the synthesis of a library of thirty eight squaric derivatives and the evaluation of activity against papain, falcipain-2 and a chloroquine-resistant strain of P. falciparum.
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There is something to be said for letting go of the mantle of expert, argues Peter Fiske.
Becoming a dummy frees you from dogma. Developing expertise can often mean ingesting unquestioned assumptions and accepted facts. Such received beliefs can lead to unchallenged group decision-making and prevent a community from recognizing a path-breaking discovery — especially when it comes from someone outside the discipline.
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When a lab runs out of money, there are a few strategies that it can use to get by.
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You et al. published in Angewandte Chemie about regulatable nanorobots: A DNA-based walking device was designed that is capable of autonomous locomotion, with light control of initiation, termination, and velocity (see picture). This device is reminiscent of cellular protein motors in nature, especially those of green plants.
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"The world in which you were born is just one model of reality. Other cultures are not failed attempts at being you. They are unique manifestations of the human spirit." -Wade Davis
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