Even though the important antimalaria drug rac-erythro-mefloquine HCl has been on the market as Lariam for decades, the absolute configurations of its enantiomers have not been determined conclusively.
Manuel Schmidt†, Han Sun†, Per Rogne‡§, Gerhard K. E. Scriba, Christian Griesinger*†, Lars T. Kuhn‡§, and Uwe M. Reinscheid*†
J. Am. Chem. Soc., Article ASAP
DOI: 10.1021/ja209050k
Publication Date (Web): December 7, 2011