Multiple sclerosis

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Multiple Sclerosis (MS) is one of the leading causes of non-traumatic neurological disability among young adults. Due to its complex pathology and the lack of reliable disease models, there are no effective therapies for MS to prevent neurodegeneration or promote neuroprotection, and hence stop disease progression. The emergence of induced pluripotent stem cells (iPSC) has allowed the generation of patient-specific neural cell types for disease modelling, drug screening, and cell therapy.

Because existing MS therapeutics suppress the immune system in a systemic way, scientists have been trying to find alternative therapies that target the disease in an antigen-specific way. This approach requires understanding which myelin self-antigens are involved in MS. Problem is, disease-causing antigens can differ among patients or change over time in the same patient.

For decades, multiple sclerosis (MS) has been depicted as a disease of the immune system running amok and attacking the whitish myelin sheath that encases the axons of the neurons in the central nervous system. The myelin is commonly analogized to insulation of electrical wiring; once compromised, the signals traveling through those axons get garbled and people with MS experience a range of neurological symptoms. In this telling, directionally MS is an “outside-in” condition of the immune system compromising the central nervous system.
But there is a camp of MS researchers who want to flip the narrative — or at least get their version considered — and have MS viewed as an “inside-out” phenomenon starting inside the central nervous system and resulting in secondary inflammation.

A medical student, Alex was diagnosed with multiple sclerosis more than 2 years ago and was distressed to learn that he had the aggressive form of MS and was on track to be in a wheelchair in a matter of months.

A Mandell Center team examines how MS-related pain impacts patients’ ability to carry out activities away from home. Plus, how cognitive strategies and family support may make a difference.

To provide clinicians who treat multiple sclerosis (MS) patients with evidence-based or expert opinion–based recommendations for promoting exercise and lifestyle physical activity across disability levels.

Multiple sclerosis affects the central nervous system. Today, on the occasion of World Multiple Sclerosis Day, here are some of the early warning signs of this disease.

World MS Day 2020 takes place tomorrow, May 30, to raise awareness for the 9,000 people in Ireland living with the debilitating neurological condition. Here, MS Ireland tell us about their plan to mark the day

People taking a drug cocktail containing one of the body’s natural immune chemicals called interferon beta 1b plus a combination HIV drug and an antiviral drug took seven days to recover from COVID-19. In comparison, it took people on only the HIV combo drug 12 days to get better, researchers report May 8 in the Lancet. Recovery included reduced shedding of virus, improvements in symptoms and discharge from the hospital.

Motor rehabilitation using virtual reality (VR) may improve hand and arm function in people with multiple sclerosis (MS), according to a review study. Evidence of its beneficial effect is, however, still preliminary, as most analyzed studies included small patient groups and some failed to show statistically significant improvements in upper limb function, the researchers noted.

As one of the world’s most common neurological disorders, multiple sclerosis (MS) is a growing cause for concern. The disease affects the central nervous system, i.e. the brain, spinal cord, and optic nerves in the body, which can lead to a variety of problems. While there is no known cure for the condition, the latest research suggests that an early diagnosis can benefit patients greatly. With that in mind, here are some of the early signs of MS you should look out for.

The companies will use a combination of more than seven years of medical record data with five years of prospective data on 5,000 MS patients, including real-world outcomes data and MRI images. Other disease areas to be explored include hematology and rare diseases.

Symptoms of the condition vary widely and primarily depends upon which nerves are affected and the amount of damage caused. Those who have severe MS may lose the ability to independently walk while others may suffer from remissions for longer periods without showing any new symptoms.

Researchers conducting a clinical trial to advance the treatment of multiple sclerosis successfully applied a new drug testing methodology which allows several treatment options to be trialled at once.

Multiple sclerosis is a disease of the brain and spinal cord, caused by demyelination of nerve fibres. In simple terms: the brain and spinal cord is like transformer (brain) & wires (spinal cord). What happens in multiple sclerosis is that, the coverings (myelin) of these wires (nerves) in the brain and spinal cord is lost/removed (demyelination).

There is no standard test to identify and diagnose MS, a neurologic disease that attacks the central nervous system. Symptoms often overlap with other conditions, such as stroke, migraines, and vitamin B12 deficiency, making it difficult to diagnose correctly.