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Suggested by
Société Francaise d'Immunologie
March 29, 2019 2:17 PM
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Ther Adv Respir Dis. 2018 Jan-Dec;12:1753466618808660. doi: 10.1177/1753466618808660.Review...
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Scooped by
Gilbert C FAURE
March 28, 2019 3:20 PM
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BMC Infect Dis. 2019 Jan 16;19(1):55. doi: 10.1186/s12879-018-3654-z.
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Scooped by
Gilbert C FAURE
March 25, 2019 3:32 PM
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A new study identifies a single molecule as a key entry point used by two types of dangerous bacteria to break through cellular barriers and cause disease.
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Scooped by
Gilbert C FAURE
March 25, 2019 3:27 PM
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<b><i>Background:</i></b> Diagnosing both celiac disease (CD) and wheat allergy (WA) might be challenging due to the increasingly popular gluten-free diets.<b><i>Objectives:</i></b> This study invest...
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Scooped by
Gilbert C FAURE
March 22, 2019 7:27 AM
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Spontaneous preterm birth, defined as birth before 37 weeks of gestation, and the related complications, are the largest contributors to infant death in the United States and worldwide, according to the World Health Organization.
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Scooped by
Gilbert C FAURE
March 19, 2019 4:53 PM
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The skin and intestine are unique environments at the front line of the immune system. Powrie and colleagues review the distinctive adaptations acquired by regulatory T cells at these barrier surfaces.
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Scooped by
Gilbert C FAURE
March 19, 2019 3:39 PM
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Recently, the risk of viral infection has dramatically increased owing to changes in human ecology such as global warming and an increased geographical movement of people and goods. Howev-er, the efficacy of vaccines and remedies for infectious diseases ...
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Scooped by
Gilbert C FAURE
March 19, 2019 2:48 PM
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Al Nabhani et al. find that the changes in the intestinal microbiota at weaning induced
a vigorous immune response—a “weaning reaction”—that is programmed in time. The weaning
reaction is associated with the induction of regulatory T cells, and its perturbation
results in increased susceptibility to immunopathologies later in life.
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Scooped by
Gilbert C FAURE
March 19, 2019 7:56 AM
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Acute respiratory distress syndrome (ARDS) is the rapid onset of noncardiogenic pulmonary oedema, hypoxaemia and the need for mechanical ventilation in hospitalized patients. This Primer describes the risk factors for ARDS, the underlying pulmonary damage and repair in ARDS and the long-term consequences for survivors.
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Scooped by
Gilbert C FAURE
March 19, 2019 5:22 AM
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World J Gastroenterol. 2019 Mar 7;25(9):1142-1157. doi: 10.3748/wjg.v25.i9.1142.
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Scooped by
Gilbert C FAURE
March 16, 2019 4:30 AM
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Exposure to microbiota, or microorganisms such as bacteria, in the early stages of life plays a crucial role in establishing optimal conditions in the intestine that inhibit the development of colon cancer in adulthood, according ...
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Suggested by
Société Francaise d'Immunologie
March 16, 2019 2:10 AM
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A natural molecule that facilitates ion transport aids lung function.
Via Krishan Maggon
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Suggested by
Société Francaise d'Immunologie
March 29, 2019 2:17 PM
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Odd-looking cells in intestine seem to use chemical sensors, including taste receptors, to detect pathogens such as parasites and sound the alarm...
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Scooped by
Gilbert C FAURE
March 25, 2019 3:36 PM
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In this study, we present a novel and effective protocol for the isolation of lymphocytes from Peyer's Patches (PPs), which can be...
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Scooped by
Gilbert C FAURE
March 25, 2019 3:28 PM
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Scooped by
Gilbert C FAURE
March 25, 2019 3:26 PM
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Mucosal-associated invariant T (MAIT) cells are nonconventional T lymphocytes that recognize bacterial metabolites presented by MR1. Whereas gut bacterial translocation and the loss/dysfunction of peripheral MAIT cells in HIV infection is well described, MAIT cells in nonhuman primate models are...
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Suggested by
LIGHTING
March 21, 2019 3:22 PM
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Scooped by
Gilbert C FAURE
March 19, 2019 4:36 PM
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Microfold (M) cells residing in the follicle-associated epithelium (FAE) of the gut-associated lymphoid tissue are specialized for antigen uptake to initiate mucosal immune responses. The molecular machinery and biological significance of M cell differentiation, however, remain to be fully elucidated. Here, we demonstrate that Sox8, a member of the SRY-related HMG box transcription factor family, is specifically expressed by M cells in the intestinal epithelium. The expression of Sox8 requires activation of RANKL-RelB signaling. Chromatin immunoprecipitation and luciferase assays revealed that Sox8 directly binds the promoter region of Gp2 to increase Gp2 expression, which is the hallmark of functionally mature M cells. Furthermore, genetic deletion of Sox8 causes a marked decrease in the number of mature M cells, resulting in reduced antigen uptake in Peyer’s patches. Consequently, juvenile Sox8 -deficient mice showed attenuated germinal center reactions and antigen-specific IgA responses. These findings indicate that Sox8 plays an essential role in the development of M cells to establish mucosal immune responses.
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Suggested by
Société Francaise d'Immunologie
March 19, 2019 3:37 PM
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The role of IFN-λ in adaptive immunity is not well characterized. Staeheli and colleagues show that in the lungs, IFN-λ elicits production of the cytokine TSLP from M cells and that this in turn is essential for effective adaptive immunity and control of infection with influenza virus.
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Scooped by
Gilbert C FAURE
March 19, 2019 10:15 AM
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Immunity. 2018 Sep 18;49(3):389-391. doi: 10.1016/j.immuni.2018.08.027. Comment
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Scooped by
Gilbert C FAURE
March 19, 2019 5:23 AM
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Scooped by
Gilbert C FAURE
March 17, 2019 2:15 PM
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A meeting report on the 7th Wellcome Trust conference on Exploring Human Host–Microbiome Interactions in Health and Disease, held at Hinxton, UK, 5–7 December 2018.
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Suggested by
Société Francaise d'Immunologie
March 16, 2019 2:11 AM
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Abstract. Latent tuberculosis infection (LTBI) is estimated in nearly one quarter of the world’s population, and of those immunocompetent and infected ~10% wil
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Scooped by
Gilbert C FAURE
March 15, 2019 12:09 PM
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