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Scooped by
Gilbert C FAURE
April 9, 2014 12:46 PM
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Medical Xpress Researchers find genetic trigger for RSV-induced infant hospitalizations Medical Xpress The discovery, published April 8 in the Journal of Clinical Investigation, is the first step toward identifying better diagnostics and potential...
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Scooped by
Gilbert C FAURE
April 9, 2014 12:28 PM
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by Guillaume Sarrabayrouse, Céline Bossard, Joe-Marc Chauvin, Anne Jarry, Guillaume Meurette, Elodie Quévrain, Chantal Bridonneau, Laurence Preisser, Karim Asehnoune, Nathalie Labarrière, Frédéric Altare, Harry Sokol, Francine Jotereau How the...
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Scooped by
Gilbert C FAURE
April 9, 2014 10:54 AM
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by Yi Lin, Xiaorui Liu, Bin Shan, Ji Wu, Surendra Sharma, Yun Sun
Objective To elucidate the mechanism by which embryo-resorption and preterm birth were enhanced by pathogenic CpG motif and to develop a counter strategy for normal pregnancy outcome.
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Scooped by
Gilbert C FAURE
April 8, 2014 3:14 AM
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IgA B Cell Responses to Gut Mucosal Antigens: Do We Know it all?
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Scooped by
Gilbert C FAURE
April 7, 2014 3:00 PM
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by
Gilbert C FAURE
April 7, 2014 7:27 AM
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The mechanisms by which mucosal homeostasis is maintained are of central importance to inflammatory bowel disease. Critical to these processes is the intestinal epithelial cell (IEC), which regulates immune responses at the interface between the commensal microbiota and the host. CD1d presents self and microbial lipid antigens to natural killer T (NKT) cells, which are involved in the pathogenesis of colitis in animal models and human inflammatory bowel disease. As CD1d crosslinking on model IECs results in the production of the important regulatory cytokine interleukin (IL)-10 (ref. 9), decreased epithelial CD1d expression[mdash]as observed in inflammatory bowel disease[mdash]may contribute substantially to intestinal inflammation. Here we show in mice that whereas bone-marrow-derived CD1d signals contribute to NKT-cell-mediated intestinal inflammation, engagement of epithelial CD1d elicits protective effects through the activation of STAT3 and STAT3-dependent transcription of IL-10, heat shock protein 110 (HSP110; also known as HSP105), and CD1d itself. All of these epithelial elements are critically involved in controlling CD1d-mediated intestinal inflammation. This is demonstrated by severe NKT-cell-mediated colitis upon IEC-specific deletion of IL-10, CD1d, and its critical regulator microsomal triglyceride transfer protein (MTP), as well as deletion of HSP110 in the radioresistant compartment. Our studies thus uncover a novel pathway of IEC-dependent regulation of mucosal homeostasis and highlight a critical role of IL-10 in the intestinal epithelium, with broad implications for diseases such as inflammatory bowel disease.
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Scooped by
Gilbert C FAURE
April 5, 2014 5:16 AM
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by Kasper Rømer Villumsen, Lukas Neumann, Maki Ohtani, Helene Kragelund Strøm, Martin Kristian Raida
The effect of oral vaccines against bacterial fish diseases has been a topic for debate for decades.
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Scooped by
Gilbert C FAURE
April 4, 2014 3:50 PM
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Fertility and Sterility, Volume null, Issue null, Pages null, null, Authors:Waltraud Eggert-Kruse, M.D.; Sandra Scholz, M.D.; Michael Kirschfink, Ph.D.; Thomas Strowitzki, M.D.
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Scooped by
Gilbert C FAURE
April 4, 2014 4:19 AM
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by Natalie J. Hannan, Katerina Bambang, Tu’uhevaha J. Kaitu’u-Lino, Justin C.
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Scooped by
Gilbert C FAURE
April 2, 2014 2:26 PM
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Research Provides Clues on How Gut Microbes Boost Immunity Doctors Lounge Arya Khosravi, Ph.D., from the California Institute of Technology in Pasadena, and colleagues utilized germ-free and antibiotic-treated mice to control the differentiation of...
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Scooped by
Gilbert C FAURE
April 2, 2014 12:26 PM
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by Simone König, Frauke Nitzki, Anja Uhmann, Kai Dittmann, Jennifer Theiss-Suennemann, Markus Herrmann, Holger M.
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Scooped by
Gilbert C FAURE
April 1, 2014 5:48 AM
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The role of minor health status in secretory immunoglobulin-A (S-IgA) reactivity to acute a... http://t.co/PyC24uaU4w (Northumbria Uni.)
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Scooped by
Gilbert C FAURE
March 31, 2014 2:52 PM
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by
Gilbert C FAURE
April 9, 2014 12:28 PM
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Scooped by
Gilbert C FAURE
April 9, 2014 11:56 AM
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Citation: Neller MA, Santner-Nanan B, Brennan RM, Hsu P, Joung S, Nanan R, Burrows SR, Miles JJ. Front Immunol. 2014 Feb 5;5:33. doi: 10.3389/fimmu.2014.00033. eCollection 2014 The human T c...
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Scooped by
Gilbert C FAURE
April 8, 2014 3:15 AM
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Scooped by
Gilbert C FAURE
April 8, 2014 3:13 AM
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Viral gastroenteritis is one of the leading causes of diseases that kill approximately 2.2 million people world wide each year. IgA is one of the major immune effector products present in the gastrointestinal tract yet its importance in protection against gastrointestinal viral infections has been difficult to prove. In part this has been due to a lack of small and large animal models in which pathogenesis of and immunity to gastrointestinal viral infections is similar to that in humans. Much of what we have learned about the role of IgA in the intestinal immune response has been obtained from experimental animal models of rotavirus infection. Rotavirus-specific intestinal IgA appears to be one of the principle effectors of long term protection against rotavirus infection. Thus, there has been a focus on understanding the immunological pathways through which this virus specific IgA is induced during infection. In addition, the experimental animal models of rotavirus infection provide excellent systems in which new areas of research on viral-specific intestinal IgA including the long term maintenance of viral-specific IgA.
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Scooped by
Gilbert C FAURE
April 7, 2014 10:27 AM
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Christina Warinner and colleagues report a high-resolution characterization of the oral microbiome isolated from the dental tissues of adult skeletons dating to 1100 CE and showing evidence of periodontal disease. They show the long-term carriage of a diverse range of opportunistic pathogens in the oral cavity and reconstruct the genome of the periodontal pathogen Tannerella forsythia.
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Scooped by
Gilbert C FAURE
April 5, 2014 2:33 PM
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Bioscience Technology Immune Cell Defenders Protect Us From Bacterial Invasion Infection Control Today The immune cells, known as mucosal-associated invariant T cells (MAITS), initiate the immune system's action against foreign invaders when they...
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Scooped by
Gilbert C FAURE
April 4, 2014 3:51 PM
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Dietary #Arginine Supplementation of Mice Alters the #Microbial Population and Activates Intestinal Innate #Immunity http://t.co/GzTVrrJNhO
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Suggested by
Société Francaise d'Immunologie
April 4, 2014 9:40 AM
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Gastroenterology, Volume null, Issue null, Pages null, null, Authors:Anna Vossenkämper; Christian Hundsrucker; Kevin Page; André van Maurik; Theodore J. Sanders; Andrew J. Stagg; Lisa Das; Thomas T.
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Scooped by
Gilbert C FAURE
April 3, 2014 8:33 AM
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by Darrell Pilling, Richard H. Gomer
Fibrosing diseases, such as pulmonary fibrosis, cardiac fibrosis, myelofibrosis, liver fibrosis, and renal fibrosis are chronic and debilitating conditions and are an increasing burden for the healthcare system.
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Scooped by
Gilbert C FAURE
April 2, 2014 2:23 PM
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PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by
Gilbert C FAURE
April 1, 2014 1:51 PM
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Scooped by
Gilbert C FAURE
April 1, 2014 5:48 AM
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The importance of Immunoglobulin A
Tri-State Neighbor
Immunoglobulins in colostrum may not be a topic swine producers have thought about much in the past, but with the outbreak of PEDv, it has become a very important topic.
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Scoop.it!
NS2 has served as a target for some mab and RNAi but these projects failed to advance to Phase III or regulatory approvals.