Mucosal Immunity
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Mucosal Immunity
The largest immune tissue in the body
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Scooped by Gilbert C FAURE
February 7, 2015 6:46 AM
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A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure

A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure | Mucosal Immunity | Scoop.it
by Francesco Tiezzi, Kristen L. Parker-Gaddis, John B. Cole, John S. Clay, Christian Maltecca
Clinical mastitis (CM) is one of the health disorders with large impacts on dairy farming profitability and animal welfare.
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February 6, 2015 2:21 PM
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Respiratory epithelial cells orchestrate pulmonary innate immunity

Nature Immunology | doi:10.1038/ni.3045
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February 5, 2015 9:39 AM
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Immunology and vaccines and nanovaccines for Helicobacter pylori in... - PubMed - NCBI

Expert Rev Vaccines. 2015 Feb 3:1-8. [Epub ahead of print]
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February 4, 2015 2:04 PM
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Accentuated hypo- and hyper-NK lymphocyte CD8 expression is a marke... - PubMed - NCBI

Immunobiology. 2014 Dec 19. pii: S0171-2985(14)00261-7. doi: 10.1016/j.imbio.2014.11.015. [Epub ahead of print]
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February 4, 2015 1:33 PM
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DNA Methylation in Cosmc Promoter Region and Aberrantly Glycosylated IgA1 Associated with Pediatric IgA Nephropathy

DNA Methylation in Cosmc Promoter Region and Aberrantly Glycosylated IgA1 Associated with Pediatric IgA Nephropathy | Mucosal Immunity | Scoop.it
by Qiang Sun, Jianqian Zhang, Nan Zhou, Xiaorong Liu, Ying Shen
IgA nephropathy (IgAN) is one of the most common glomerular diseases leading to end-stage renal failure. Elevation of aberrantly glycosylated IgA1 is a key feature of it.
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February 4, 2015 12:58 PM
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Suppression of p21Rac signaling and increased innate immunity media... - PubMed - NCBI

Sci Transl Med. 2014 Apr 23;6(233):233ra53. doi: 10.1126/scitranslmed.3006763. Research Support, Non-U.S. Gov't
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Scooped by Gilbert C FAURE
February 3, 2015 2:03 PM
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Nasal Associated Lymphoid Tissue of the Syrian Golden Hamster Expresses High Levels of PrPC

Nasal Associated Lymphoid Tissue of the Syrian Golden Hamster Expresses High Levels of PrPC | Mucosal Immunity | Scoop.it
by Melissa D. Clouse, Ronald A. Shikiya, Jason C. Bartz, Anthony E.
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February 3, 2015 1:43 PM
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Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg bala... - PubMed - NCBI

J Leukoc Biol. 2015 Jan 30. pii: jlb.3HI0614-303R. [Epub ahead of print]
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Scooped by Gilbert C FAURE
February 3, 2015 1:39 PM
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Diagnosis and Treatment of C difficile in Adults

Diagnosis and Treatment of C difficile in Adults | Mucosal Immunity | Scoop.it
Importance  Since 2000, the incidence and severity of Clostridium difficile infection (CDI) have increased.Objective  To review current evidence regarding best practices for the diagnosis and treatment of CDI in adults (age ≥18...
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February 2, 2015 2:34 PM
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Altered gut microbiota seen in patients with psoriatic arthritis - Healio

Altered gut microbiota seen in patients with psoriatic arthritis - Healio | Mucosal Immunity | Scoop.it
Rheumatology | Patients with psoriatic arthritis and psoriasis showed a lower number of multiple intestinal bacteria and decreased overall diversity of species, according to newly published data.Sixteen patients with psoriatic arthritis (PsA), 15 ...
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February 2, 2015 2:33 PM
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Intestinal dendritic cells in the regulation of mucosal immunity. - PubMed - NCBI

Immunol Rev. 2014 Jul;260(1):86-101. doi: 10.1111/imr.12194. Research Support, Non-U.S. Gov't; Review
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February 2, 2015 1:01 PM
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Frontiers | Mucosal-Associated Invariant T Cells in Inflammatory Bowel Diseases: Bystanders, Defenders, or Offenders? | Mucosal Immunity

The quest for new therapeutics and better follow-up of patients with inflammatory bowel diseases (IBD) requires the clearest possible picture of the immunological mechanisms underlying these comple...
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February 1, 2015 1:23 PM
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Nephrokeli, a Chinese Herbal Formula, May Improve IgA Nephropathy through Regulation of the Sphingosine-1-Phosphate Pathway

Nephrokeli, a Chinese Herbal Formula, May Improve IgA Nephropathy through Regulation of the Sphingosine-1-Phosphate Pathway | Mucosal Immunity | Scoop.it
by Yifei Zhong, Ke Wang, Xianwen Zhang, Xiaofan Cai, Yiping Chen, Yueyi Deng
Nephrokeli (NPKL) is a Chinese herbal formula that has been used to treat patients with IgA nephropathy (IgAN) for improvement of proteinuria and kidney injury.
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February 7, 2015 6:44 AM
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Intestinal Lesions Are Associated with Altered Intestinal Microbiome and Are More Frequent in Children and Young Adults with Cystic Fibrosis and Cirrhosis

Intestinal Lesions Are Associated with Altered Intestinal Microbiome and Are More Frequent in Children and Young Adults with Cystic Fibrosis and Cirrhosis | Mucosal Immunity | Scoop.it
by Thomas Flass, Suhong Tong, Daniel N. Frank, Brandie D. Wagner, Charles E. Robertson, Cassandra Vogel Kotter, Ronald J. Sokol, Edith Zemanick, Frank Accurso, Edward J. Hoffenberg, Michael R.
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February 6, 2015 2:01 PM
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Another breastfeeding benefit: Preparing baby's belly for solid food

Another breastfeeding benefit: Preparing baby's belly for solid food | Mucosal Immunity | Scoop.it
Researchers found that a baby’s diet during the first few months of life has a profound influence on the composition, diversity, and stability of the gut microbiome.
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Scooped by Gilbert C FAURE
February 5, 2015 9:22 AM
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Intestinal dendritic cells. - PubMed - NCBI

Curr Opin Gastroenterol. 2015 Mar;31(2):98-103.
Gilbert C FAURE's insight:
RECENT FINDINGS:

The identification of dendritic cell subsets and phenotypic markers within the healthy and diseased intestine has progressed significantly, including improved identification of dendritic cell subsets within the human intestine. Recently, the role for dietary factors and the microbiome in modulating the intestinal dendritic cell functions has begun to be better investigated, resulting in a number of new findings relating to retinoic acid metabolism, pattern recognition receptor triggering and G-protein-coupled receptor activation. In addition, the interactions between goblet cells and mucin with intestinal dendritic cells are being better defined.

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February 4, 2015 1:35 PM
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Application of the C3-Binding Motif of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Invasive Group A Streptococcal Infection

Application of the C3-Binding Motif of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Invasive Group A Streptococcal Infection | Mucosal Immunity | Scoop.it
by Chih-Feng Kuo, Nina Tsao, Miao-Hui Cheng, Hsiu-Chen Yang, Yu-Chieh Wang, Ying-Pin Chen, Kai-Jen Lin
Group A streptococcus (GAS) is an important human pathogen that produces several extracellular exotoxins to facilitate invasion and infection.
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February 4, 2015 1:32 PM
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Chronic Bronchitis and Current Smoking Are Associated with More Goblet Cells in Moderate to Severe COPD and Smokers without Airflow Obstruction

Chronic Bronchitis and Current Smoking Are Associated with More Goblet Cells in Moderate to Severe COPD and Smokers without Airflow Obstruction | Mucosal Immunity | Scoop.it
by Victor Kim, Michelle Oros, Heba Durra, Steven Kelsen, Mark Aksoy, William D. Cornwell, Thomas J. Rogers, Gerard J. Criner
Background Goblet cell hyperplasia is a classic but variable pathologic finding in COPD.
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Suggested by Société Francaise d'Immunologie
February 4, 2015 3:05 AM
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B Cell Bosses | The Scientist Magazine®

B Cell Bosses | The Scientist Magazine® | Mucosal Immunity | Scoop.it
Gut bacteria in mice spur regulatory B cells to differentiate and release an anti-inflammatory cytokine.
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Scooped by Gilbert C FAURE
February 3, 2015 2:03 PM
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Proteomics-Driven Analysis of Ovine Whey Colostrum

Proteomics-Driven Analysis of Ovine Whey Colostrum | Mucosal Immunity | Scoop.it
by Domenica Scumaci, Francesca Trimboli, Ludovica Dell’Aquila, Antonio Concolino, Giusi Pappaianni, Laura Tammè, Giorgio Vignola, Alessia Luciani, Daniela Morelli, Giovanni Cuda, Andrea Boari, Domenico Britti The aim of this study was to shed light...
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Suggested by Société Francaise d'Immunologie
February 3, 2015 1:43 PM
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Chemokine receptors and their therapeutic opportunities in diseased... - PubMed - NCBI

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 30:ajplung.00203.2014. doi: 10.1152/ajplung.00203.2014. [Epub ahead of print]
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Scooped by Gilbert C FAURE
February 3, 2015 4:20 AM
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Jumping DNA and the Evolution of Pregnancy – Phenomena: Not Exactly Rocket Science

Jumping DNA and the Evolution of Pregnancy – Phenomena: Not Exactly Rocket Science | Mucosal Immunity | Scoop.it
About a decade ago, Vincent Lynch emailed Frank Grutzner to ask for a tissue sample from a pregnant platypus. He got a polite brush-off instead. Then, around eight years later, Grutzner got back in...
Gilbert C FAURE's insight:

nice approach, would have been difficult to finance as a big classical clinical research project

Dr Richard Badge's curator insight, February 3, 2015 5:48 PM

This is a must read paper for me!

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February 2, 2015 2:34 PM
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Characterization of a plant-produced recombinant human secretory Ig... - PubMed - NCBI

MAbs. 2014 Nov 2;6(6):1585-97. doi: 10.4161/mabs.36336.
Gilbert C FAURE's insight:

IgA

with broad neutralizing activity against HIV.
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February 2, 2015 2:09 PM
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Oral innate immunity in human immunodefienciency virus infection in the era of highly active antiretroviral therapy - Nittayananta - 2015 - Journal of Oral Pathology & Medicine - Wiley Online Library

Oral innate immunity in human immunodefienciency virus infection in the era of highly active antiretroviral therapy - Nittayananta - 2015 - Journal of Oral Pathology & Medicine - Wiley Online Library | Mucosal Immunity | Scoop.it
Oral innate immunity in human immunodefienciency virus infection in the era of highly active antiretroviral th... http://t.co/WWdCvzPiDS
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Scooped by Gilbert C FAURE
February 2, 2015 5:03 AM
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Frontiers | Resident-memory CD8 T cells and mTOR: Generation, Protection, and Clinical Importance. | Immunological Memory

Tissues such as the lung, skin, intestinal epithelium, and reproductive tract serve as a barricade against pathogen exposure for the entire body. Specifically within the skin and mucosal tissues, a...
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