#Eawag researchers present in @NatureComms a fast and easy method for cell-based analysis of stream biofilm: https://t.co/LALHYapso1 | Quorum sensing
Mucosal Immunity
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The finding showed that Zika virus could infect Hofbauer cells -- placental macrophages -- in cell culture
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Notch inhibition leads to loss of adult intestinal stem cells & secretory cell hyperplasia @Dev_journal 2012 https://t.co/fwSRWr2f8d
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The transcription factor hepatocyte nuclear factor 4-alpha (HNF4-alpha) plays a key role in colon cancer and colitis. HNF4-alpha comes in two major isoforms, P1 and P2, but how these are distributed in the gut is not understood.
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Clinical & Translational Immunology focuses on the general functioning of the immune system in its broadest sense, with a particular emphasis on its cell biology. Areas that are covered include but are not limited to: Cellular immunology, Innate and adaptive immunity, Immune responses to pathogens,Tumour immunology,Immunopathology, Immunotherapy, Immunogenetics, Immunological studies in humans and model organisms (including mouse, rat, Drosophila etc)
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From
gut
Objective To determine the existence of mucosal dysbiosis in siblings of patients with Crohn's disease (CD) using 454 pyrosequencing and to comprehensively characterise and determine the influence of genotypical and phenotypical factors, on that...
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[Research Article] IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches https://t.co/fU6dmdgzWB
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Half a billion dollars are being pledged to study the microbes in humans, crops, soils, oceans, and more.
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Gilbert C FAURE's insight:
The subepithelial dome (SED) area of intestinal Peyer’s patches is a major hub for serial interactions between B cells and DCs that play a critical role in the induction of secretory IgA. Reboldi et al. report in the May 13 issue of Science that pre-germinal center B cells require the CCR6 chemokine receptor to follow a CCL20 gradient and efficiently enter the SED “workspace”. Once they reach the SED, CCR6+ B cells undergo a series of intimate interactions with αvβ8 integrin-expressing DCs. The DC αvβ8 converts latent TGF-β to active TGF-β, which is the key cytokine driving IgA class switching by the B cells. http://science.sciencemag.org/content/352/6287/aaf4822.full
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This study evaluated the associations between clinical, microbiological, and antibody activity manifestations of periodontitis in 123 adult rural Chinese subjects with no dental intervention.
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Report shows many countries yet to ban aggressive marketing of breast milk substitutes.
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A group of researchers at Osaka University elucidated how a gene named Ly6/Plaur domain containing 8 (Lypd8) inhibits bacterial invasion of colonic epithelia, regulating intestinal inflammation.
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Jpn J Ophthalmol. 2016 Apr 28. [Epub ahead of print]
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From
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Anal. Methods, 2016, Advance Article
DOI: 10.1039/C6AY00792A, PaperXiaoqi Tao, Song Zhou, Xiameng Yuan, Hongjun Li Development of 10 chemiluminescent immunoassays for the detection of CAP for a comparison study.
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Bruno Lamas, Mathias L Richard, Valentin Leducq, Hang-Phuong Pham, Marie-Laure Michel, Gregory Da Costa, Chantal Bridonneau, Sarah Jegou, Thomas W Hoffmann, Jane M Natividad, Loic Brot, Soraya Taleb, Aurélie Couturier-Maillard, Isabelle Nion-Larmurier, Fatiha Merabtene, Philippe Seksik, Anne Bourrier, Jacques Cosnes, Bernhard Ryffel, Laurent Beaugerie, Jean-Marie Launay, Philippe Langella, Ramnik J Xavier & Harry Sokol
Gilbert C FAURE's insight:
Nature Medicine (2016) doi:10.1038/nm.4102 Received 19 December 2015 Accepted 08 April 2016 Published online 09 May 2016 Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and caspase recruitment domain family member 9 (CARD9), a susceptibility gene for inflammatory bowel disease (IBD) that functions in the immune response against microorganisms. CARD9 promotes recovery from colitis by promoting interleukin (IL)-22 production, and Card9−/− mice are more susceptible to colitis. The microbiota is altered in Card9−/− mice, and transfer of the microbiota from Card9−/− to wild-type, germ-free recipients increases their susceptibility to colitis. The microbiota from Card9−/− mice fails to metabolize tryptophan into metabolites that act as aryl hydrocarbon receptor (AHR) ligands. Intestinal inflammation is attenuated after inoculation of mice with three Lactobacillus strains capable of metabolizing tryptophan or by treatment with an AHR agonist. Reduced production of AHR ligands is also observed in the microbiota from individuals with IBD, particularly in those with CARD9 risk alleles associated with IBD. Our findings reveal that host genes affect the composition and function of the gut microbiota, altering the production of microbial metabolites and intestinal inflammation.
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The Human Fertilisation & Embryology Authority and several leading experts have warned that some treatments offered by private fertility clinics do not have a sound evidence base. Here are some of the treatments that have been questioned...
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Gut. 2016 Feb;65(2):256-70. doi: 10.1136/gutjnl-2014-307916. Epub 2015 Feb 9. Comparative Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues.
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Publication date: 9 May 2016 Source:Current Biology, Volume 26, Issue 9 Author(s): Ray Soto, June Round The majority of bacteria found within the gut are commensals, although it is unclear whether these organisms can elicit systemic...
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From
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RT @JurisGrasis: An integrated systems-wide view of the immune system using CyTOF. Truly really cool work!
https://t.co/2B3AFOykm0
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Am J Physiol Renal Physiol. 2016 May 11:ajprenal.00607.2016. doi: 10.1152/ajprenal.00607.2015. [Epub ahead of print]
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White House initiative will advance research into using bacteria to fight disease, pollution
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Maternal antibodies engender a receptive gut environment for beneficial bacteria in newborn mice.
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