Classical dendritic cells are required for dietary antigen–mediated induction of peripheral Treg cells and tolerance Daria Esterházy, Jakob Loschko, Mariya London, Veronica Jove, Thiago Y Oliveira & Daniel Mucida AffiliationsContributionsCorresponding author Nature Immunology 17, 545–555 (2016) doi:10.1038/ni.3408
Mucosal Immunity
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Publication date: April 2016
Source:Cancer Epidemiology, Volume 41 Author(s): Freddy Sitas Stomach cancer is one of the leading causes of cancer death worldwide, despite its incidence and mortality falling in many places. 
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Nature. 2016 May 25;534(7606):263-6. doi: 10.1038/nature17940. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Traditionally, the dental profession has primarily treated periodontitis using a mechanical/surgical, rather than a pharmaceutical, approach.
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Changes in diet and microbiota have determining effects on the function of the mucosal immune system.
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Our bodies are confused by this 21st-century world.
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Curr Opin Immunol. 2016 May 30;42:41-47. doi: 10.1016/j.coi.2016.05.009. [Epub ahead of print] REVIEW
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See why the PD-L1 protein is such an important target in cancer immunotherapy research. Via Krishan Maggon
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Contemporary Clinical Dentistry 2016 7(2):140-145 Background: To analyze the role of proinflammatory cytokines in drug-induced gingival enlargement in Indian population.
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Immunology. 2016 Jan;147(1):1-10. doi: 10.1111/imm.12538. Epub 2015 Nov 2. Research Support, N.I.H., Extramural; Review
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The life span of intestinal epithelial cells (IECs) is short (3–5 days), and its regulation is thought to be important for homeostasis of the intestinal epithelium.
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Advances in Human Microbiome Science: Gut–Brain Interaction | The New York Academy of Sciences https://t.co/zwRaOIVTqt via @sharethis
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Platelet-released growth factors (PRGF) and its related clinically used formulations [e.g. Vivostat platelet-rich fibrin (PRF®)] are thrombocyte concentrate lysates that support healing of chronic, hard-to-heal and infected wounds.
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Within the gut, the immune system must strike a perfect balance between protecting our bodies from infection and not overreacting to harmless foreign entities, including food. A new study explores the origins of a type of immune cell that appears to keep inflammatory responses in check.
Gilbert C FAURE's insight:
Many T regs migrated into the epithelium from the body, but never returned. To find out what was happening to these immune cells, they labeled the T regs and watched them over five weeks. In that time, they found that about half of the T regs stopped expressing the protein Foxp3, an important marker of regulatory T cells. Of these, a portion converted to CD4 IELs. This is the first time T-regs have been shown to switch their identity and turn into another cell type within a living organism; until now, they have been thought to be stable. The microbes living on the other side of the gut epithelium appear to contribute to this conversion. When the researchers treated mice with antibiotics, the T-regs stopped switching their identity. "This research reveals how the gut has evolved its own specialized pathway for maintaining the delicate balance between an efficient immune response and the need for tolerance," says Mucida.
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The role of microbes in the gut has been the focus of recent research that explores how dietary choices promote cooperation or might fuel conflict between gut microbes and the humans they interact with, maintaining health or encouraging the onset...
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Front Immunol. 2015 Nov 20;6:590. doi: 10.3389/fimmu.2015.00590. eCollection 2015. Review
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Nestlé and Imperial College London (ICL) are kicking off their new nutritional science partnership by investigating how fibre consumption can improve metabolic health, mental performance and digestive health in seniors.
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Gastroenterology. 2016 Feb;150(2):340-54. doi: 10.1053/j.gastro.2015.10.046. Epub 2015 Nov 6. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
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J Interferon Cytokine Res. 2015 Sep;35(9):682-9. doi: 10.1089/jir.2014.0123. Epub 2015 May 18. Research Support, Non-U.S. Gov't
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BMC Immunol. 2016 May 31;17(1):12. doi: 10.1186/s12865-016-0153-0.
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Mathematician Lydia Bourouiba uses high-speed video to break down the anatomy of sneezes and coughs — and to understand infectious disease.
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Article Citation: Hwajeong Lee, Maria Westerhoff, Bo Shen, and Xiuli Liu (2016) Clinical Aspects of Idiopathic Inflammatory Bowel Disease: A Review for Pathologists. Archives of Pathology & Laboratory Medicine: May 2016, Vol. 140, No. 5, pp. 413-428. doi: http://dx.doi.org/10.5858/arpa.2015-0305-RA
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J Allergy Clin Immunol. 2016 Jan;137(1):214-22.e2. doi: 10.1016/j.jaci.2015.07.042. Epub 2015 Sep 26. Research Support, Non-U.S. Gov't
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