Its vaccines could be an interesting alternative to current treatments, known as ‘desensitization’ or conventional Allergy Immunotherapy (AIT). This process of inducing tolerance to the allergen requires 3-5 years – time that could be saved with Anergis’ products.
The new invention uses a patch to monitor blood sugar levels via sweat, and delivers the diabetes drug metformin through the skin with microneedles. "Diabetics are reluctant to monitor their blood glucose levels because of the painful blood-gathering process," said study author Hyunjae Lee, from Seoul National University in the Republic of Korea. "We highly focused on a noninvasive monitoring and therapy system for diabetics."
Latest advances in 3M hollow microneedle technology. 3M hollow microneedle technology offers a patient-friendly intradermal delivery solution for difficult to deliver biologics, and provides an updated design based on human factors testing and voice-of-the customer research
Here we describe a novel, microfluidic, drop dispensing-based dissolvable microneedle production method that overcomes these issues. Uniquely, heterogeneous arrays, consisting of microneedles of diverse composition, can be easily produced on the same patch. Robustness of the process was demonstrated by incorporating and stabilizing adenovirus and MVA vaccines. Clinically-available trivalent inactivated influenza vaccine (TIV) in DMN patches is fully stable for greater than 6 months at 40 °C. Immunization using low dose TIV-loaded DMN patches induced significantly higher antibody responses compared to intramuscular-based immunization in mice.
We describe, for the first time, stimulus-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 h). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in “on-demand” delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.
Meant to accelerate the potential of immunotherapy in treating cancer, The National Immunotherapy Coalition has just been launched by leaders from Amgen, Celgene, GlaxoSmithKline, Merck, and NantWorks – along with Independence Blue Cross and many others. Here’s why:
The purpose of this study was to evaluate the characteristics of exendin-4 tip-loaded microneedle arrays and to compare their acute efficacy with subcutaneous injections in type 2 diabetic GK/Slc rats.
The results illustrate that this microneedle delivery system is effective in delivering collagen I into the epidermis and dermis of porcine and human skin. Since the technique presented in this paper is quick, safe, effective and easy, it can be considered as a new collagen delivery method for cosmetic and therapeutic applications.
Our pioneering oncology research and development could potentially transform the way cancer is treated. See how AbbVie teams are working together to take on the challenges of cancer.
In recent years there has been a growing concern regarding needle-based drug delivery devices due to needle phobia, increasing cases of needlestick injuries and the transmission of blood-borne diseases. Needle-free drug delivery devices are considered as an effective alternative and novel technique to introduce drugs into a patient's body without invading the skin with a needle. It is growing in popularity and has received considerable attention during the past few years primarily due to painless, effective and safe drug delivery methods. Needle-free drug delivery devices typically include needle-free injectors, inhalers, transdermal patches and other devices based on novel needle technologies (e.g., microneedles and advanced pen needles).
Carl Schoellhammer, winner of the 2015 Lemelson-MIT National Collegiate Student prize in the "Cure it!" graduate category is developing two inventions that will drastically enhance pain-free drug delivery in patients via the gastrointestinal (GI) tract. His first invention, the Microneedle Pill (mPill), allows medicine that is traditionally administered by painful injection to be ingested orally. The ingestible capsule has small micron-scale needles protruding from it, which introduce the drug directly into the GI tissue in a painless and safe manner. His second invention, the Ultrasound Probe (uProbe), enables the fast, local delivery of therapeutics to the GI tract by using low frequency ultrasound to physically drive medication into tissue painlessly.
The patches deliver anti-PD-1 antibodies that prevent the cancer from confusing T cells into ignoring the tumor. Previously, the antibodies have been tried through injections, but not enough reach the cancer cells while potentially causing side effects throughout the body. The antibodies are placed within nanoparticles which are then loaded within the microneedles along with glucose oxidase. When the patches are applied to cancer sites, the blood enters the needles, the glucose reacts with glucose oxidase producing acid that breaks up the nanoparticles. This allows anti-PD-1 to be released in a controlled manner right into the tumor.
An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation. One MN patch can quickly reduce the blood-sugar levels (BGLs) of chemically induced type-1 diabetic mice and stabilize BGLs at a reduced level for over 10 h.
Measles is a killer. This viral disease claimed more than 300 lives every day, on average, in 2014 alone. That's according to the World Health Organization in Geneva, Switzerland. Yet a life-saving vaccine has been available since 1963. Two doses can keep almost everyone who gets them from catching the measles. And outbreaks can largely be prevented if most people who are able to get the vaccine in fact do receive it. And a new drug-dispensing patch could help that happen. It could make it easier to bring the vaccine to the children who need it — especially those in rural areas of developing countries.
Successful development of siRNA therapies has significant potential for the treatment of skin conditions (alopecia, allergic skin diseases, hyperpigmentation, psoriasis, skin cancer, pachyonychia congenital) caused by aberrant gene expression. Although hypodermic needles can be used to effectively deliver siRNA through the stratum corneum, the major challenge is that this approach is painful and the effects are restricted to the injection site. Microneedle arrays may represent a better way to deliver siRNAs across the stratum corneum.
The Georgia Institute of Technology and Micron Biomedical have been awarded $2.5 million in grants from the Bill & Melinda Gates Foundation to advance the development of dissolvable microneedle patches for polio immunization. The patches will be studied to evaluate their potential role as part of the worldwide efforts to eradicate polio.
Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node. Masahiro Kitano et al (2016), Proceedings of the National Academy of ...
Taken together, these data show auto-antigenic peptide delivery into skin using coated MNs results in prolonged retention and enhanced antigen presentation compared to conventional ID delivery and this approach may have potential in individuals identified as being at a high risk of developing type 1 diabetes and other autoimmune diseases.
Please visit us at http://clinicalresolution.com for any questions about microneedling and skincare products. This video covers the mechanics of the InnoPen ...
The aim of this project was to study the influence of microneedles on transdermal delivery of amantadine hydrochloride and pramipexole dihydrochloride across porcine ear skin in vitro. Microchannel visualization studies were carried out and characterization of the microchannel depth was performed using confocal laser scanning microscopy (CLSM) to demonstrate microchannel formation following microneedle roller application.
This review explores the feasibility of innovative MNs used as a drug delivery carrier. Because most of the SMNs and HMNs have many limitations, it is difficult to achieve therapeutic efficacy. Therefore, many scientists are investigating functional modifications of MNs through covalent and non-covalent methods, especially for CMNs and DMNs. The biomedical applications of MNs are growing and new exciting improvements could be achieved, thus resulting in better micro/nano technologies in the near future.
Researchers at MIT are developing a method of delivering vaccines with patches of tiny needles that would embed a substance containing the vaccine onto the skin, much like a tattoo. The technique would eliminate the need of a syringe. The microneedles would measure 250 microns wide by 650 microns long, and would be coated with a biodegradable film comprised of layers of polymers containing the vaccine. The patch of microneedles would penetrate the skin less than a millimeter (650 microns) deep, enough to deliver the vaccine, but not deep enough to affect blood vessels and nerve endings to cause pain. The patch would embed the film into the skin. The film would gradually wear away over a sustained period of time, gradually releasing the vaccine into the skin.
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