OND are developing novel techniques and materials to produce low cost needle patches to deliver vaccines and drugs to the immune system http://www.oxfordnanodelivery.com
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Intra-Dermal drug delivery: Opportunities and Challenges?
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Microneedles continue to show promise as a replacement - in at least some applications - for the hypodermic needle. Typically, a sheet containing an array of the tiny needles is adhered to the patient's skin, like a bandage. The microneedles painlessly pierce the top layer of skin, then gradually deliver the medication within them by harmlessly dissolving into the patient's bloodstream. As an added bonus, once everything is complete, there are no bio-hazardous used needles to dispose of. Now, bioengineers from Massachusetts' Tufts University have de Via Jean-Philippe BOCQUENET 
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The market is still in its infancy. So far, only one microneedle based delivery device, Soluvia prefilled microinjection system, has reached the market. The vaccine-device combination product was FDA approved in May 2011 for intradermal delivery of Fluzone influenza vaccine. We have identified more than 25 companies, with proprietary microneedle technology, actively working towards the development of microneedle-based drug or vaccine products. Clearside Biomedical, NanoPass Technologies, Corium International, Circassia, Radius Health and Zosano Pharma are examples of companies which are evaluating microneedle based drug/vaccine – device combination products (referred to as products hereafter) in clinical trials.
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A microneedle patch being developed by Georgia Tech and the Centers for Disease Control and Prevention (CDC) could make it easier to vaccinate people ...
Yotam Levin's insight:
Prof Prausnitz has been a pioneer in microneedle development for over a decade. It has taken over a decade to get to prototype stage and preliminary clinical trials and I believe another decade to mature, but this is indeed the future, at least for important high demand vaccines that require rapid distribution (e.g. pandemic vaccines).
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Microneedles could also be used for drug delivery. The team has reportedly used the same microneedle patches to administer a wide variety of drugs, and immunologists are already excited about their potential for delivering vaccines painlessly and easily. There's no word yet on cost or timeframe — as you'd expect, the patches need to undergo rounds of clinical testing before they'll be seen in the real world. But if they deliver even half of their promise, it could be a major leap forward for medical science. And, most importantly, no more painful trips to the doctor.
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Dr Ryan Donnelly, from the School of Pharmacy at Queen's University Belfast, demonstrates his microneedle technology that could revolutionise the way drugs are delivered -- from small molecules to vaccines and biological compounds.
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Scientists at King's have demonstrated the ability to deliver a dried live vaccine to the skin without a traditional needle, and shown for the first time tha...
Yotam Levin's insight:
King's is one of many leading academia exploring microneedle vaccine delivery. It does require a critical mass of clinical trials and peer reviewed publications to persuade the relevant stakeholders, mostly big vaccine pharma companies and regulators, to promote, develop and foster micorneedle developments. Eventually, through concerted and massive efforts of many, we will prevail.
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