AUTOIMMUNITY
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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Scooped by Gilbert C FAURE
August 23, 2013 4:26 AM
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Effect of antithyroid antibodies on ICS... [Reprod Biomed Online. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Scooped by Gilbert C FAURE
August 22, 2013 5:40 AM
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Negligible impact of rare autoimmune-locus coding-region variants on missing heritability : Nature : Nature Publishing Group

Genome-wide association studies (GWAS) have identified common variants of modest-effect size at hundreds of loci for common autoimmune diseases; however, a substantial fraction of heritability remains unexplained, to which rare variants may...
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Scooped by Gilbert C FAURE
August 21, 2013 2:15 AM
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Chronic Idiopathic Urticaria and Thyroid Autoimmunity: Perplexing Association | Allergy, Asthma and Immunology

“@Aller_MD: Chronic Idiopathic Urticaria and Thyroid Autoimmunity: Perplexing Association http://t.co/X5rmX95aba”;
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Scooped by Gilbert C FAURE
August 19, 2013 3:05 PM
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All About Autoimmunity Ask the Expert: Dr. Noel Rose | Irish America

Irish America Magazine (RT @mindtraps: All About Autoimmunity Ask the Expert: Dr.
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Scooped by Gilbert C FAURE
August 19, 2013 8:43 AM
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What causes relapses of autoimmune diseases? The etiological role of autoreactive T cells

What causes relapses of autoimmune diseases? The etiological role of autoreactive T cells | AUTOIMMUNITY | Scoop.it
RT @ImmunologyNews: What causes relapses of autoimmune diseases? New article in Autoimmunity Reviews http://t.co/qRAqdL7ZY9
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Scooped by Gilbert C FAURE
August 16, 2013 2:41 PM
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Cerebral FDG-PET and MRI findings in autoimmune limbic encephalitis: correlation with autoantibody types - Online First - Springer

Cerebral FDG-PET and MRI findings in autoimmune limbic encephalitis: correlation with autoantibody types - Online First - Springer | AUTOIMMUNITY | Scoop.it
Cerebral FDG-PET and MRI findings in autoimmune limbic encephalitis: correlation with autoantibody types http://t.co/M6gBQUgZMg #Springer
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Scooped by Gilbert C FAURE
August 16, 2013 2:38 PM
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Genalyte Launches Type 1 Diabetes Antigen Panel, BDC Collaboration - Genetic Engineering News

Genalyte Launches Type 1 Diabetes Antigen Panel, BDC Collaboration - Genetic Engineering News | AUTOIMMUNITY | Scoop.it
Genalyte Launches Type 1 Diabetes Antigen Panel, BDC Collaboration
Genetic Engineering News
The T1D panel measures autoantibodies to insulin, proinsulin, GAD 65, GAD 67, IA-2 (PTPRN, ICA512), phogrin (PTPRN2, IA-2beta), and ZnT8 (SLC30A8).
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Scooped by Gilbert C FAURE
August 11, 2013 4:12 PM
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Frontiers | Modulation of T Lymphocyte Calcium Influx Patterns Via the Inhibition of Kv1.3 and Ikca1 Potassium Channels in Autoimmune Disorders | Frontiers in T Cell Biology

Frontiers | Modulation of T Lymphocyte Calcium Influx Patterns Via the Inhibition of Kv1.3 and Ikca1 Potassium Channels in Autoimmune Disorders | Frontiers in T Cell Biology | AUTOIMMUNITY | Scoop.it
Modulation of T Lymphocyte Calcium Influx Patterns Via the Inhibition of Kv1.3 and Ikca1 Potassium Channels in Autoimmune Disorders (Modulation of T Lymphocyte Calcium Influx Patterns Via the Inhibition of Kv1.3 and Ikca1 Potassium...
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Scooped by Gilbert C FAURE
August 11, 2013 4:09 PM
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Natural history of celiac disease autoimmunity in a USA cohort followed since 1974.

Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. | AUTOIMMUNITY | Scoop.it
Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. (#natural Natural history of celiac disease autoimmunity in a USA cohort followed since 1974...
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Scooped by Gilbert C FAURE
August 9, 2013 11:05 AM
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Antineutrophil cytoplasm antibody–associated vasculitis: recent developments.

Antineutrophil cytoplasm antibody–associated vasculitis: recent developments. | AUTOIMMUNITY | Scoop.it
Antineutrophil cytoplasm antibody (ANCA)–associated vasculitis (AAV) is a group of vasculitides characterized by small-to-medium-sized blood vessel vasculitis and the presence of ANCA. Although our...
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Scooped by Gilbert C FAURE
August 1, 2013 3:31 PM
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Trends in Immunology - Modeling the heterogeneity of multiple sclerosis in animals

TrendsImmunol: FREE featured article on modeling heterogeneity of MS in animal models. Goverman lab. http://t.co/XsUhBIGdGO
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Scooped by Gilbert C FAURE
August 1, 2013 2:48 AM
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Therapy for severe vasculitis shows long-term effectiveness - EurekAlert (press release)

Therapy for severe vasculitis shows long-term effectiveness EurekAlert (press release) Those who suffer from these rare autoimmune diseases—termed anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides—produce antibodies that attack...
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Scooped by Gilbert C FAURE
July 31, 2013 12:47 PM
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Frontiers | Ly9 (CD229) Cell-Surface Receptor is Crucial for the Development of Spontaneous Autoantibody Production to Nuclear Antigens | Frontiers in Inflammation

Frontiers | Ly9 (CD229) Cell-Surface Receptor is Crucial for the Development of Spontaneous Autoantibody Production to Nuclear Antigens | Frontiers in Inflammation | AUTOIMMUNITY | Scoop.it
Frontiers | Ly9 (CD229) Cell-Surface Receptor is Crucial for the Development of Spontaneous Autoantibody Production to Nuclear Antigens | Frontiers in Inflammation publishes articles on the most outstanding discoveries across the research spectrum...
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Scooped by Gilbert C FAURE
August 22, 2013 5:56 AM
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Update on pathogenesis and treatment of CLE

Update on pathogenesis and treatment of CLE | AUTOIMMUNITY | Scoop.it
Rheumatology Medical Article: Update on pathogenesis and treatment of CLE (Update on pathogenesis and treatment of CLE: Current Opinion in Rheumatology http://t.co/CRiW0WHZVc #Rheumatology)...
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Scooped by Gilbert C FAURE
August 21, 2013 2:17 AM
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The whys and hows of rituximab in thyroid eye disease - ModernMedicine

The whys and hows of rituximab in thyroid eye disease
ModernMedicine
The chimeric monoclonal antibody targets the CD20 antigen on an ion channel specific to mature B-lymphocytes. Rituximab causes ...
Gilbert C FAURE's insight:

rituximab becoming a first-line treatment?

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Scooped by Gilbert C FAURE
August 19, 2013 3:09 PM
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Improving the Clinical Utility of Antinuclear Antibody Repor... : Pathology - Journal of the RCPA

An abstract is unavailable. (Most Popular: Improving the Clinical Utility of Antinuclear Antibody Reporting By Incorporating Likelihood Rat...
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Scooped by Gilbert C FAURE
August 19, 2013 2:56 PM
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Frontiers | Increased Serum Type I Interferon Activity in Organ-Specific Autoimmune Disorders: Clinical, Imaging, and Serological Associations | Frontiers in Molecular Innate Immunity

Frontiers | Increased Serum Type I Interferon Activity in Organ-Specific Autoimmune Disorders: Clinical, Imaging, and Serological Associations | Frontiers in Molecular Innate Immunity | AUTOIMMUNITY | Scoop.it
Background: Activation of the type I interferon (IFN) pathway has been implicated in the pathogenesis of systemic autoimmune disorders but its role in the pathogenesis of organ-specific autoimmunity is unknown.
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Rescooped by Gilbert C FAURE from Immunology for University Students
August 16, 2013 3:01 PM
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The pathogenesis of systemic lupus erythematosus—an update-Current Opinion in Immunology -

The pathogenesis of systemic lupus erythematosus—an update-Current Opinion in Immunology - | AUTOIMMUNITY | Scoop.it

The pathogenesis of systemic lupus erythematosus—an update

Jinyoung Choi1, *,Sang Taek Kim1, *,Joe Craft1, 2,

1 Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States2 Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, United States

http://dx.doi.org/10.1016/j.coi.2012.10.004,

 

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

 

The pathogenesis of systemic lupus erythematosus—an update [Current Opinion in Immunology—an update] http://t.co/gKMERgRK...


Via Alfredo Corell
Gilbert C FAURE's comment, August 17, 2013 11:26 AM
november 2012, a synthetic review of uptodate hypothesis
Scooped by Gilbert C FAURE
August 16, 2013 2:39 PM
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MACL Launches Blood Test to Aid in the Early Detection of Lung Cancer - San Francisco Chronicle (press release)

MACL Launches Blood Test to Aid in the Early Detection of Lung Cancer - San Francisco Chronicle (press release) | AUTOIMMUNITY | Scoop.it
MACL Launches Blood Test to Aid in the Early Detection of Lung Cancer
San Francisco Chronicle (press release)
Seventeen peer-reviewed publications support the EarlyCDT® autoantibody platform, click here.
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Scooped by Gilbert C FAURE
August 16, 2013 2:22 PM
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Paraneoplastic neurological syndromes - Leypoldt - Clinical & Experimental Immunology - Wiley Online Library

Paraneoplastic neurological syndromes - Leypoldt - Clinical & Experimental Immunology - Wiley Online Library | AUTOIMMUNITY | Scoop.it
Paraneoplastic neurological syndromes Leypoldt Clinical & Experimental Immunology Wiley Online Library http://t.co/C9NgBxJuBn
Gilbert C FAURE's curator insight, March 4, 2014 10:00 AM

Paraneoplastic neurological syndromes are immune-mediated erroneous attacks on the central or peripheral nervous systems, or both, directed originally against the tumour itself. They have been known for more than 40 years, but recently the discovery of new subgroups of paraneoplastic encephalitis syndromes with a remarkably good response to immune therapy has ignited new clinical and scientific interest. Knowledge of these subgroups and their associated autoantibodies is important in therapeutic decision-making. However, the abundance of new autoantibodies and syndromes can be confusing. This review paper summarizes current knowledge and new developments in the field of paraneoplastic neurological syndromes, their classification, pathophysiology and treatment.

Scooped by Gilbert C FAURE
August 11, 2013 4:10 PM
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MD Biosciences Offers IL-23-Induced Psoriasis-Like Preclinical Model for Skin ... - PR Web (press release)

MD Biosciences Offers IL-23-Induced Psoriasis-Like Preclinical Model for Skin ... - PR Web (press release) | AUTOIMMUNITY | Scoop.it
MD Biosciences Offers IL-23-Induced Psoriasis-Like Preclinical Model for Skin ...
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Scooped by Gilbert C FAURE
August 11, 2013 10:12 AM
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Effects of rituximab-based B-cell depletion therapy on skin manifestations of lupus erythematosus – report of 17 cases and review of the literature

"Effects of rituximab-based B-cell depletion therapy on skin manifestations of #lupus" http://t.co/NvolfCatui #rheumedu
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Scooped by Gilbert C FAURE
August 6, 2013 2:42 PM
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Cross-linking of IgGs bound on circulating neutrophils leads to an ...

Cross-linking of IgGs bound on circulating neutrophils leads to an ... | AUTOIMMUNITY | Scoop.it
Cross-linking of IgGs bound on circulating neutrophils leads to an activation of endothelial cells: possible role of rheumatoid factors in rheumatoid arthritis-associated vascular dysfunction. Emmanuelle Rollet-Labelle*, Myriam ...
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Scooped by Gilbert C FAURE
August 1, 2013 10:12 AM
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Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in B6.Sle1b mice and is suppressed by the H1-isoform of the Slamf6 receptor

Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in... http://t.co/f7dkn5OsE9 #FASEBTCB
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Scooped by Gilbert C FAURE
August 1, 2013 2:46 AM
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Proinsulin/Insulin Autoantibodies Measured With...

Proinsulin/Insulin Autoantibodies Measured With... | AUTOIMMUNITY | Scoop.it
Proinsulin/Insulin Autoantibodies Measured With Electrochemiluminescent Assay Are the Earliest Indicator of Prediabetic Islet Autoimmunity on diabetes and more curated by Ellen H Ullman, MSW (Proinsulin/Insulin Autoantibodies Measured With...
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